Mutations in ABCB1
reference sequence
Region |
Mutation |
|
|
Publications |
Sentences |
MutMiner_hits |
SNAP2 |
PROVEAN |
Effect_ExpVar |
CL0 |
p.Met
1
Val
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
CL0 |
p.Gly
10
Arg
|
details |
homologous mutations |
1 |
21 |
25 |
N |
N |
? |
CL0 |
p.Phe
17
Leu
|
details |
homologous mutations |
3 |
4 |
4 |
N |
N |
? |
CL0 |
p.Asn
21
Asp
|
details |
homologous mutations |
68 |
172 |
198 |
N |
N |
? |
CL0 |
p.Asn
21
Val
|
details |
homologous mutations |
2 |
26 |
27 |
N |
N |
? |
CL0 |
p.Ser
23
Cys
|
details |
homologous mutations |
2 |
16 |
18 |
N |
N |
? |
CL0 |
p.Ser
23
Ala
|
details |
homologous mutations |
1 |
6 |
6 |
N |
N |
? |
CL0 |
p.Lys
25
Phe
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
CL0 |
p.Asp
26
Glu
|
details |
homologous mutations |
2 |
13 |
13 |
N |
N |
? |
CL0 |
p.Pro
32
Asp
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
CL0 |
p.Val
34
Ala
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
CL0 |
p.Ser
35
Ala
|
details |
homologous mutations |
1 |
3 |
3 |
D |
N |
? |
CL0 |
p.Ser
35
Ile
|
details |
homologous mutations |
1 |
4 |
4 |
D |
D |
? |
CL0 |
p.Phe
37
Ala
|
details |
homologous mutations |
3 |
18 |
20 |
D |
N |
? |
CL0 |
p.Tyr
42
Ala
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
CL0 |
p.Ser
43
Gly
|
details |
homologous mutations |
1 |
2 |
3 |
N |
N |
? |
CL0 |
p.Asn
44
Ser
|
details |
homologous mutations |
4 |
8 |
8 |
N |
N |
? |
CL0 |
p.Trp
45
Ala
|
details |
homologous mutations |
1 |
2 |
2 |
N |
D |
? |
CL0 |
p.Lys
48
Arg
|
details |
homologous mutations |
2 |
6 |
7 |
N |
N |
? |
CL0 |
p.Lys
48
Asn
|
details |
homologous mutations |
1 |
3 |
4 |
N |
N |
? |
TMD1,TH1 |
p.Met
51
Cys
|
details |
homologous mutations |
2 |
3 |
3 |
N |
D |
? |
TMD1,TH1 |
p.Val
52
Cys
|
details |
homologous mutations |
3 |
4 |
4 |
N |
N |
? |
TMD1,TH1 |
p.Val
52
Arg
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD1,TH1 |
p.Val
53
Cys
|
details |
homologous mutations |
3 |
9 |
9 |
N |
N |
? |
TMD1,TH1 |
p.Val
53
Arg
|
details |
homologous mutations |
1 |
5 |
5 |
D |
D |
? |
TMD1,TH1 |
p.Gly
54
Cys
|
details |
homologous mutations |
2 |
5 |
5 |
D |
D |
? |
TMD1,TH1 |
p.Gly
54
Trp
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,TH1 |
p.Gly
54
Arg
|
details |
homologous mutations |
2 |
4 |
4 |
D |
D |
? |
TMD1,TH1 |
p.Gly
54
Val
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
TMD1,TH1 |
p.Thr
55
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,TH1 |
p.Thr
55
Arg
|
details |
homologous mutations |
2 |
6 |
6 |
D |
D |
? |
TMD1,TH1 |
p.Leu
56
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
N |
? |
TMD1,TH1 |
p.Leu
56
Arg
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD1,TH1 |
p.Ala
57
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
N |
? |
TMD1,TH1 |
p.Ala
57
Arg
|
details |
homologous mutations |
2 |
4 |
4 |
N |
N |
? |
TMD1,TH1 |
p.Ala
57
Leu
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,TH1 |
p.Ala
58
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
TMD1,TH1 |
p.Ala
58
Arg
|
details |
homologous mutations |
2 |
4 |
4 |
D |
D |
? |
TMD1,TH1 |
p.Ala
58
Leu
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,TH1 |
p.Ile
59
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,TH1 |
p.Ile
59
Arg
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD1,TH1 |
p.Ile
60
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
N |
? |
TMD1,TH1 |
p.Ile
60
Arg
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
TMD1,TH1 |
p.Ile
60
Leu
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,TH1 |
p.His
61
Arg
|
details |
homologous mutations |
5 |
9 |
9 |
D |
D |
? |
TMD1,TH1 |
p.His
61
Cys
|
details |
homologous mutations |
1 |
7 |
7 |
N |
D |
? |
TMD1,TH1 |
p.His
61
Lys
|
details |
homologous mutations |
1 |
3 |
3 |
D |
D |
? |
TMD1,TH1 |
p.His
61
Phe
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD1,TH1 |
p.His
61
Met
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,TH1 |
p.His
61
Ala
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD1,TH1 |
p.Gly
62
Cys
|
details |
homologous mutations |
2 |
3 |
3 |
D |
D |
? |
TMD1,TH1 |
p.Gly
62
Arg
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,TH1 |
p.Ala
63
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,TH1 |
p.Ala
63
Arg
|
details |
homologous mutations |
2 |
6 |
6 |
D |
D |
? |
TMD1,TH1 |
p.Gly
64
Arg
|
details |
homologous mutations |
4 |
28 |
29 |
D |
D |
? |
TMD1,TH1 |
p.Gly
64
Cys
|
details |
homologous mutations |
1 |
4 |
4 |
N |
N |
? |
TMD1,TH1 |
p.Leu
65
Arg
|
details |
homologous mutations |
5 |
36 |
37 |
N |
D |
? |
TMD1,TH1 |
p.Leu
65
Cys
|
details |
homologous mutations |
6 |
54 |
75 |
N |
D |
? |
TMD1,TH1 |
p.Leu
65
Ala
|
details |
homologous mutations |
1 |
10 |
10 |
N |
D |
? |
TMD1,TH1 |
p.Pro
66
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,TH1 |
p.Pro
66
Ser
|
details |
homologous mutations |
1 |
6 |
9 |
D |
D |
? |
TMD1,TH1 |
p.Pro
66
Arg
|
details |
homologous mutations |
1 |
3 |
3 |
D |
D |
? |
TMD1,TH1 |
p.Leu
67
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,TH1 |
p.Leu
67
Arg
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD1,TH1 |
p.Met
68
Cys
|
details |
homologous mutations |
3 |
5 |
5 |
D |
D |
? |
TMD1,TH1 |
p.Met
68
Arg
|
details |
homologous mutations |
2 |
54 |
56 |
D |
D |
? |
TMD1,TH1 |
p.Met
69
Cys
|
details |
homologous mutations |
1 |
4 |
4 |
N |
N |
? |
TMD1,TH1 |
p.Met
69
Arg
|
details |
homologous mutations |
2 |
10 |
10 |
D |
D |
? |
TMD1,TH1 |
p.Leu
70
Pro
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,TH1 |
p.Leu
70
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,TH1 |
p.Leu
70
Arg
|
details |
homologous mutations |
1 |
3 |
3 |
D |
D |
? |
TMD1,TH1 |
p.Leu
70
Gly
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD1,TH1 |
p.Val
71
Cys
|
details |
homologous mutations |
1 |
2 |
2 |
N |
D |
? |
TMD1,TH1 |
p.Val
71
Arg
|
details |
homologous mutations |
1 |
9 |
9 |
D |
D |
? |
TMD1,EL1 |
p.Phe
72
Arg
|
details |
homologous mutations |
2 |
6 |
6 |
D |
D |
? |
TMD1,EL1 |
p.Thr
76
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,EL1 |
p.Ala
80
Glu
|
details |
homologous mutations |
5 |
5 |
5 |
D |
N |
? |
TMD1,EL1 |
p.Ala
80
Gly
|
details |
homologous mutations |
3 |
18 |
19 |
N |
N |
? |
TMD1,EL1 |
p.Ala
80
Pro
|
details |
homologous mutations |
1 |
1 |
1 |
D |
N |
? |
TMD1,EL1 |
p.Ala
80
Cys
|
details |
homologous mutations |
2 |
141 |
166 |
N |
N |
? |
TMD1,EL1 |
p.Ala
80
Arg
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,EL1 |
p.Met
89
Thr
|
details |
homologous mutations |
10 |
26 |
27 |
N |
N |
? |
TMD1,EL1 |
p.Asn
91
Gln
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,EL1 |
p.Asn
91
Ala
|
details |
homologous mutations |
4 |
8 |
8 |
N |
N |
? |
TMD1,EL1 |
p.Asn
94
Gln
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,EL1 |
p.Asn
94
Ala
|
details |
homologous mutations |
4 |
9 |
9 |
N |
N |
? |
TMD1,EL1 |
p.Asn
99
Gln
|
details |
homologous mutations |
2 |
2 |
2 |
N |
N |
? |
TMD1,EL1 |
p.Asn
99
Ala
|
details |
homologous mutations |
4 |
8 |
8 |
N |
N |
? |
TMD1,EL1 |
p.Gly
102
Arg
|
details |
homologous mutations |
2 |
6 |
6 |
N |
N |
? |
TMD1,EL1 |
p.Phe
103
Leu
|
details |
homologous mutations |
32 |
57 |
59 |
N |
N |
? |
TMD1,EL1 |
p.Phe
104
Val
|
details |
homologous mutations |
2 |
3 |
4 |
N |
N |
? |
TMD1,EL1 |
p.Glu
108
Lys
|
details |
homologous mutations |
5 |
16 |
17 |
N |
N |
? |
TMD1,EL1 |
p.Glu
109
Lys
|
details |
homologous mutations |
3 |
8 |
8 |
N |
N |
? |
TMD1,EL1 |
p.Arg
113
Ala
|
details |
homologous mutations |
2 |
22 |
23 |
N |
N |
? |
TMD1,EL1 |
p.Arg
113
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,EL1 |
p.Arg
113
Met
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,EL1 |
p.Arg
113
Glu
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,EL1 |
p.Arg
113
Lys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,EL1 |
p.Tyr
114
Cys
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD1,EL1 |
p.Tyr
114
Glu
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,EL1 |
p.Tyr
114
Met
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,EL1 |
p.Tyr
114
Lys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,EL1 |
p.Tyr
114
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,TH2 |
p.Tyr
118
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,TH2 |
p.Ile
121
Phe
|
details |
homologous mutations |
1 |
2 |
2 |
N |
D |
? |
TMD1,TH2 |
p.Ala
123
Leu
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,TH2 |
p.Val
125
Leu
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,TH2 |
p.Val
125
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,TH2 |
p.Val
125
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,TH2 |
p.Ala
128
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,TH2 |
p.Ala
129
Cys
|
details |
homologous mutations |
2 |
7 |
7 |
N |
D |
? |
TMD1,TH2 |
p.Ala
129
Arg
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD1,TH2 |
p.Tyr
130
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
TMD1,TH2 |
p.Ile
131
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
D |
? |
TMD1,TH2 |
p.Gln
132
Cys
|
details |
homologous mutations |
3 |
3 |
3 |
D |
D |
? |
TMD1,TH2 |
p.Gln
132
Arg
|
details |
homologous mutations |
3 |
49 |
64 |
D |
D |
? |
TMD1,TH2 |
p.Gln
132
Ala
|
details |
homologous mutations |
2 |
5 |
9 |
D |
D |
? |
TMD1,TH2 |
p.Ser
134
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
D |
? |
TMD1,TH2 |
p.Trp
136
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
TMD1,TH2 |
p.Trp
136
Arg
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD1,TH2 |
p.Cys
137
Ser
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,TH2 |
p.Leu
138
Cys
|
details |
homologous mutations |
3 |
4 |
4 |
N |
D |
? |
TMD1,TH2 |
p.Ala
139
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,TH2 |
p.Ala
140
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,TH2 |
p.Gly
141
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,TH2 |
p.Gly
141
Lys
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
TMD1,TH2 |
p.Gly
141
Val
|
details |
homologous mutations |
5 |
9 |
10 |
N |
D |
? |
TMD1,CL1 |
p.Ile
144
Thr
|
details |
homologous mutations |
2 |
3 |
4 |
N |
N |
? |
TMD1,CL1 |
p.Ala
154
Gly
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,CL1 |
p.Ala
154
Thr
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,CL1 |
p.Gln
158
Lys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,CL1 |
p.Gln
158
Gly
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,CL1 |
p.Ile
160
Thr
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,CL1 |
p.Gly
161
Val
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,CL1 |
p.Phe
163
Cys
|
details |
homologous mutations |
1 |
4 |
4 |
D |
D |
? |
TMD1,CL1 |
p.Asp
164
Ala
|
details |
homologous mutations |
2 |
4 |
4 |
D |
D |
? |
TMD1,CL1 |
p.Asp
164
Cys
|
details |
homologous mutations |
2 |
15 |
18 |
D |
D |
? |
TMD1,CL1 |
p.Asp
164
Gln
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD1,CL1 |
p.Val
168
Ile
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,CL1 |
p.Leu
171
Pro
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD1,CL1 |
p.Leu
175
Cys
|
details |
homologous mutations |
5 |
86 |
97 |
N |
D |
? |
TMD1,CL1 |
p.Leu
175
Asn
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,CL1 |
p.Thr
176
Cys
|
details |
homologous mutations |
1 |
1 |
6 |
D |
D |
? |
TMD1,CL1 |
p.Asp
177
Cys
|
details |
homologous mutations |
3 |
37 |
46 |
D |
D |
? |
TMD1,CL1 |
p.Asp
178
His
|
details |
homologous mutations |
1 |
2 |
3 |
D |
D |
? |
TMD1,CL1 |
p.Asp
178
Cys
|
details |
homologous mutations |
1 |
1 |
6 |
D |
D |
? |
TMD1,CL1 |
p.Val
179
Met
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
TMD1,CL1 |
p.Asn
183
Ser
|
details |
homologous mutations |
25 |
33 |
37 |
N |
N |
? |
TMD1,CL1 |
p.Gly
185
Val
|
details |
homologous mutations |
74 |
276 |
328 |
D |
D |
D |
TMD1,CL1 |
p.Gly
185
Cys
|
details |
homologous mutations |
2 |
20 |
25 |
D |
D |
? |
TMD1,CL1 |
p.Ile
186
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,CL1 |
p.Ile
186
Asn
|
details |
homologous mutations |
3 |
59 |
79 |
D |
D |
? |
TMD1,CL1 |
p.Gly
187
Val
|
details |
homologous mutations |
3 |
4 |
5 |
D |
D |
? |
TMD1,CL1 |
p.Gly
187
Glu
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD1,CL1 |
p.Asp
188
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,CL1 |
p.Lys
189
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
TMD1,CL1 |
p.Ile
190
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
D |
? |
TMD1,CL1 |
p.Gly
191
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
TMD1,CL1 |
p.Gly
191
Arg
|
details |
homologous mutations |
6 |
14 |
15 |
D |
D |
? |
TMD1,CL1 |
p.Met
192
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
TMD1,CL1 |
p.Phe
193
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
D |
? |
TMD1,CL1 |
p.Phe
194
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
D |
? |
TMD1,CL1 |
p.Gln
195
Cys
|
details |
homologous mutations |
3 |
6 |
7 |
D |
D |
? |
TMD1,TH3 |
p.Ser
196
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,TH3 |
p.Ser
196
Gly
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,TH3 |
p.Met
197
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,TH3 |
p.Ala
198
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,TH3 |
p.Thr
199
Ala
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD1,TH3 |
p.Thr
199
Arg
|
details |
homologous mutations |
1 |
5 |
5 |
D |
D |
? |
TMD1,TH3 |
p.Thr
199
Cys
|
details |
homologous mutations |
2 |
15 |
16 |
D |
D |
? |
TMD1,TH3 |
p.Phe
200
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,TH3 |
p.Phe
201
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,TH3 |
p.Thr
202
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,TH3 |
p.Gly
203
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,TH3 |
p.Phe
204
Ser
|
details |
homologous mutations |
4 |
6 |
7 |
D |
D |
? |
TMD1,TH3 |
p.Ile
205
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,TH3 |
p.Gly
207
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,TH3 |
p.Phe
208
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,TH3 |
p.Thr
209
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
N |
? |
TMD1,TH3 |
p.Arg
210
Gly
|
details |
homologous mutations |
1 |
2 |
2 |
N |
D |
? |
TMD1,TH3 |
p.Arg
210
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,TH3 |
p.Gly
211
Ala
|
details |
homologous mutations |
4 |
7 |
7 |
N |
D |
? |
TMD1,TH3 |
p.Gly
211
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,TH3 |
p.Trp
212
Arg
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,TH3 |
p.Trp
212
*
|
details |
homologous mutations |
1 |
1 |
1 |
- |
- |
? |
TMD1,EL2 |
p.Ala
220
Gly
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,EL2 |
p.Ala
220
Ser
|
details |
homologous mutations |
5 |
9 |
9 |
N |
N |
? |
TMD1,EL2 |
p.Ser
222
Cys
|
details |
homologous mutations |
2 |
3 |
3 |
N |
D |
? |
TMD1,EL2 |
p.Ser
222
Thr
|
details |
homologous mutations |
1 |
2 |
2 |
N |
D |
? |
TMD1,EL2 |
p.Pro
223
Ala
|
details |
homologous mutations |
8 |
9 |
10 |
D |
D |
? |
TMD1,TH4 |
p.Gly
226
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,TH4 |
p.Gly
226
Thr
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,TH4 |
p.Leu
227
Cys
|
details |
homologous mutations |
1 |
5 |
5 |
N |
D |
? |
TMD1,TH4 |
p.Ser
228
Thr
|
details |
homologous mutations |
2 |
2 |
2 |
N |
N |
? |
TMD1,TH4 |
p.Ser
228
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,TH4 |
p.Ser
228
Asn
|
details |
homologous mutations |
1 |
1 |
1 |
D |
N |
? |
TMD1,TH4 |
p.Ala
229
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,TH4 |
p.Ala
229
Val
|
details |
homologous mutations |
1 |
3 |
3 |
N |
D |
? |
TMD1,TH4 |
p.Ala
230
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,TH4 |
p.Trp
232
Cys
|
details |
homologous mutations |
3 |
7 |
7 |
N |
D |
? |
TMD1,TH4 |
p.Trp
232
Arg
|
details |
homologous mutations |
2 |
75 |
89 |
D |
D |
? |
TMD1,TH4 |
p.Trp
232
Ala
|
details |
homologous mutations |
1 |
12 |
13 |
D |
D |
? |
TMD1,TH4 |
p.Trp
232
*
|
details |
homologous mutations |
1 |
2 |
2 |
- |
- |
? |
TMD1,TH4 |
p.Ala
233
Cys
|
details |
homologous mutations |
1 |
4 |
4 |
N |
D |
? |
TMD1,TH4 |
p.Lys
234
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,TH4 |
p.Ile
235
Cys
|
details |
homologous mutations |
1 |
4 |
4 |
N |
D |
? |
TMD1,TH4 |
p.Ile
235
Leu
|
details |
homologous mutations |
1 |
4 |
5 |
N |
N |
? |
TMD1,TH4 |
p.Leu
236
Cys
|
details |
homologous mutations |
1 |
4 |
4 |
D |
D |
? |
TMD1,TH4 |
p.Ser
237
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,CL2 |
p.Glu
243
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,CL2 |
p.Ala
250
Pro
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD1,CL2 |
p.Gly
251
Val
|
details |
homologous mutations |
10 |
160 |
220 |
D |
D |
? |
TMD1,CL2 |
p.Val
253
Ser
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,CL2 |
p.Glu
255
Lys
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
TMD1,CL2 |
p.Glu
255
Val
|
details |
homologous mutations |
3 |
3 |
3 |
D |
D |
? |
TMD1,CL2 |
p.Glu
255
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,CL2 |
p.Glu
256
Ala
|
details |
homologous mutations |
1 |
7 |
7 |
D |
D |
? |
TMD1,CL2 |
p.Glu
256
Arg
|
details |
homologous mutations |
1 |
8 |
9 |
D |
D |
? |
TMD1,CL2 |
p.Leu
258
Ile
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,CL2 |
p.Ala
259
Gln
|
details |
homologous mutations |
1 |
1 |
1 |
D |
N |
? |
TMD1,CL2 |
p.Ala
259
Leu
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,CL2 |
p.Ala
259
Cys
|
details |
homologous mutations |
2 |
11 |
11 |
D |
N |
? |
TMD1,CL2 |
p.Ala
260
Leu
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,CL2 |
p.Ile
261
Val
|
details |
homologous mutations |
9 |
12 |
12 |
D |
N |
? |
TMD1,CL2 |
p.Arg
262
Ala
|
details |
homologous mutations |
2 |
4 |
4 |
D |
D |
? |
TMD1,CL2 |
p.Arg
262
Thr
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,CL2 |
p.Arg
262
Ile
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,CL2 |
p.Thr
263
Ala
|
details |
homologous mutations |
2 |
4 |
4 |
D |
D |
? |
TMD1,CL2 |
p.Val
264
Ser
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
TMD1,CL2 |
p.Ile
265
Ser
|
details |
homologous mutations |
2 |
2 |
2 |
N |
D |
? |
TMD1,CL2 |
p.Ala
266
Cys
|
details |
homologous mutations |
4 |
13 |
14 |
D |
D |
? |
TMD1,CL2 |
p.Ala
266
Phe
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD1,CL2 |
p.Ala
266
Leu
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,CL2 |
p.Phe
267
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,CL2 |
p.Phe
267
Ala
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
TMD1,CL2 |
p.Gly
268
Val
|
details |
homologous mutations |
9 |
68 |
78 |
D |
D |
? |
TMD1,CL2 |
p.Gly
269
Val
|
details |
homologous mutations |
4 |
9 |
9 |
D |
D |
? |
TMD1,CL2 |
p.Lys
271
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,CL2 |
p.Lys
272
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,CL2 |
p.Glu
273
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,CL2 |
p.Glu
275
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,CL2 |
p.Arg
276
Ala
|
details |
homologous mutations |
1 |
7 |
7 |
D |
D |
? |
TMD1,CL2 |
p.Arg
276
Glu
|
details |
homologous mutations |
1 |
8 |
9 |
D |
D |
? |
TMD1,CL2 |
p.Tyr
277
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,CL2 |
p.Asn
280
Cys
|
details |
homologous mutations |
1 |
7 |
8 |
N |
D |
? |
TMD1,CL2 |
p.Lys
285
Thr
|
details |
homologous mutations |
1 |
1 |
2 |
N |
D |
? |
TMD1,CL2 |
p.Gly
288
Val
|
details |
homologous mutations |
3 |
4 |
5 |
D |
D |
? |
TMD1,TH5 |
p.Ile
293
Cys
|
details |
homologous mutations |
2 |
5 |
6 |
N |
D |
? |
TMD1,TH5 |
p.Thr
294
Cys
|
details |
homologous mutations |
2 |
2 |
3 |
D |
D |
? |
TMD1,TH5 |
p.Thr
294
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,TH5 |
p.Ala
295
Cys
|
details |
homologous mutations |
3 |
8 |
9 |
N |
D |
? |
TMD1,TH5 |
p.Asn
296
Cys
|
details |
homologous mutations |
5 |
27 |
34 |
D |
D |
? |
TMD1,TH5 |
p.Asn
296
Ala
|
details |
homologous mutations |
1 |
19 |
21 |
D |
D |
? |
TMD1,TH5 |
p.Ile
297
Cys
|
details |
homologous mutations |
2 |
7 |
13 |
N |
D |
? |
TMD1,TH5 |
p.Ile
297
Arg
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD1,TH5 |
p.Ser
298
Cys
|
details |
homologous mutations |
2 |
2 |
3 |
N |
D |
? |
TMD1,TH5 |
p.Ser
298
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,TH5 |
p.Ser
298
Arg
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD1,TH5 |
p.Ile
299
Met
|
details |
homologous mutations |
3 |
3 |
4 |
N |
N |
? |
TMD1,TH5 |
p.Ile
299
Cys
|
details |
homologous mutations |
2 |
25 |
43 |
N |
N |
? |
TMD1,TH5 |
p.Gly
300
Val
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD1,TH5 |
p.Ala
301
Thr
|
details |
homologous mutations |
2 |
5 |
5 |
N |
N |
? |
TMD1,TH5 |
p.Ala
301
Val
|
details |
homologous mutations |
2 |
8 |
9 |
N |
N |
? |
TMD1,TH5 |
p.Ala
301
Cys
|
details |
homologous mutations |
2 |
2 |
3 |
N |
N |
? |
TMD1,TH5 |
p.Ala
301
Asp
|
details |
homologous mutations |
1 |
4 |
4 |
D |
N |
? |
TMD1,TH5 |
p.Ala
302
Cys
|
details |
homologous mutations |
2 |
2 |
3 |
N |
N |
? |
TMD1,TH5 |
p.Ala
302
Arg
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,TH5 |
p.Phe
303
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,TH5 |
p.Phe
303
Arg
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD1,TH5 |
p.Leu
304
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,TH5 |
p.Ile
306
Cys
|
details |
homologous mutations |
10 |
68 |
73 |
D |
D |
? |
TMD1,TH5 |
p.Ile
306
Glu
|
details |
homologous mutations |
1 |
8 |
8 |
D |
D |
? |
TMD1,TH5 |
p.Ile
306
Arg
|
details |
homologous mutations |
7 |
66 |
77 |
D |
D |
? |
TMD1,TH5 |
p.Ile
306
Ala
|
details |
homologous mutations |
3 |
15 |
15 |
D |
D |
? |
TMD1,TH5 |
p.Tyr
307
Cys
|
details |
homologous mutations |
1 |
27 |
46 |
D |
D |
? |
TMD1,TH5 |
p.Tyr
307
Phe
|
details |
homologous mutations |
1 |
2 |
7 |
N |
N |
? |
TMD1,TH5 |
p.Tyr
307
Arg
|
details |
homologous mutations |
1 |
5 |
5 |
D |
D |
? |
TMD1,TH5 |
p.Tyr
310
Phe
|
details |
homologous mutations |
1 |
2 |
7 |
N |
D |
? |
TMD1,TH5 |
p.Ala
313
Gly
|
details |
homologous mutations |
8 |
47 |
50 |
N |
D |
? |
TMD1,TH5 |
p.Phe
314
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,EL3 |
p.Trp
315
Arg
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD1,EL3 |
p.Thr
318
Ser
|
details |
homologous mutations |
1 |
5 |
5 |
N |
N |
? |
TMD1,EL3 |
p.Thr
319
Ser
|
details |
homologous mutations |
3 |
3 |
4 |
N |
N |
? |
TMD1,EL3 |
p.Leu
322
Ile
|
details |
homologous mutations |
4 |
8 |
9 |
N |
N |
? |
TMD1,EL3 |
p.Leu
322
Pro
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD1,EL3 |
p.Gly
324
Lys
|
details |
homologous mutations |
4 |
9 |
10 |
N |
N |
? |
TMD1,EL3 |
p.Gly
324
Cys
|
details |
homologous mutations |
5 |
26 |
28 |
D |
D |
? |
TMD1,EL3 |
p.Glu
325
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,EL3 |
p.Ser
327
Thr
|
details |
homologous mutations |
1 |
5 |
5 |
N |
N |
? |
TMD1,EL3 |
p.Gln
330
Asn
|
details |
homologous mutations |
2 |
12 |
12 |
N |
N |
? |
TMD1,TH6 |
p.Val
331
Cys
|
details |
homologous mutations |
2 |
8 |
8 |
N |
D |
? |
TMD1,TH6 |
p.Val
331
Ala
|
details |
homologous mutations |
2 |
12 |
12 |
N |
N |
? |
TMD1,TH6 |
p.Leu
332
Cys
|
details |
homologous mutations |
8 |
34 |
38 |
N |
D |
? |
TMD1,TH6 |
p.Leu
332
Val
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,TH6 |
p.Leu
332
Met
|
details |
homologous mutations |
2 |
12 |
12 |
N |
N |
? |
TMD1,TH6 |
p.Thr
333
Cys
|
details |
homologous mutations |
4 |
40 |
45 |
D |
D |
? |
TMD1,TH6 |
p.Phe
335
Ala
|
details |
homologous mutations |
11 |
22 |
23 |
D |
D |
? |
TMD1,TH6 |
p.Phe
335
Ser
|
details |
homologous mutations |
2 |
4 |
4 |
D |
D |
? |
TMD1,TH6 |
p.Phe
335
Leu
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
TMD1,TH6 |
p.Phe
335
Cys
|
details |
homologous mutations |
6 |
13 |
13 |
D |
D |
? |
TMD1,TH6 |
p.Phe
335
Tyr
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,TH6 |
p.Phe
336
Cys
|
details |
homologous mutations |
2 |
5 |
5 |
D |
D |
? |
TMD1,TH6 |
p.Phe
336
Ser
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,TH6 |
p.Phe
336
Arg
|
details |
homologous mutations |
2 |
4 |
4 |
D |
D |
? |
TMD1,TH6 |
p.Phe
336
Ala
|
details |
homologous mutations |
2 |
17 |
17 |
D |
D |
? |
TMD1,TH6 |
p.Ser
337
Cys
|
details |
homologous mutations |
1 |
5 |
5 |
N |
D |
? |
TMD1,TH6 |
p.Val
338
Ala
|
details |
homologous mutations |
6 |
9 |
10 |
D |
D |
? |
TMD1,TH6 |
p.Leu
339
Cys
|
details |
homologous mutations |
16 |
88 |
99 |
N |
D |
? |
TMD1,TH6 |
p.Leu
339
Val
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,TH6 |
p.Ile
340
Cys
|
details |
homologous mutations |
4 |
10 |
10 |
N |
D |
? |
TMD1,TH6 |
p.Ile
340
Ala
|
details |
homologous mutations |
2 |
16 |
16 |
D |
D |
? |
TMD1,TH6 |
p.Gly
341
Val
|
details |
homologous mutations |
5 |
5 |
6 |
D |
D |
? |
TMD1,TH6 |
p.Gly
341
Cys
|
details |
homologous mutations |
10 |
42 |
43 |
D |
D |
? |
TMD1,TH6 |
p.Gly
341
Ala
|
details |
homologous mutations |
1 |
4 |
4 |
N |
D |
? |
TMD1,TH6 |
p.Ala
342
Cys
|
details |
homologous mutations |
3 |
12 |
12 |
D |
D |
? |
TMD1,TH6 |
p.Phe
343
Cys
|
details |
homologous mutations |
16 |
81 |
90 |
D |
D |
? |
TMD1,TH6 |
p.Phe
343
Arg
|
details |
homologous mutations |
3 |
12 |
13 |
D |
D |
? |
TMD1,TH6 |
p.Phe
343
Tyr
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
TMD1,TH6 |
p.Phe
343
Met
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,TH6 |
p.Phe
343
Ala
|
details |
homologous mutations |
2 |
16 |
16 |
D |
D |
? |
TMD1,TH6 |
p.Ser
344
Cys
|
details |
homologous mutations |
3 |
26 |
29 |
N |
N |
? |
TMD1,TH6 |
p.Ser
344
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
D |
N |
? |
TMD1,TH6 |
p.Val
345
Cys
|
details |
homologous mutations |
2 |
31 |
32 |
D |
D |
? |
TMD1,TH6 |
p.Gly
346
Cys
|
details |
homologous mutations |
8 |
82 |
88 |
D |
D |
? |
TMD1,TH6 |
p.Gln
347
Cys
|
details |
homologous mutations |
4 |
24 |
27 |
D |
D |
? |
TMD1,TH6 |
p.Gln
347
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD1,TH6 |
p.Ala
348
Cys
|
details |
homologous mutations |
1 |
9 |
10 |
N |
D |
? |
TMD1,TH6 |
p.Ser
349
Cys
|
details |
homologous mutations |
2 |
14 |
15 |
D |
N |
? |
TMD1,TH6 |
p.Ser
349
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,TH6 |
p.Pro
350
Cys
|
details |
homologous mutations |
6 |
46 |
55 |
D |
D |
? |
TMD1,TH6 |
p.Pro
350
Ser
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD1,TH6 |
p.Ser
351
Asn
|
details |
homologous mutations |
3 |
3 |
4 |
N |
N |
? |
TMD1,TH6 |
p.Ser
351
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD1,TH6 |
p.Ser
351
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
CL3 |
p.Ala
354
Cys
|
details |
homologous mutations |
2 |
33 |
38 |
D |
D |
? |
CL3 |
p.Ala
354
Gly
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
CL3 |
p.Gly
360
Cys
|
details |
homologous mutations |
3 |
15 |
16 |
D |
D |
? |
CL3 |
p.Ala
361
Thr
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3 |
p.Ile
369
Val
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
CL3 |
p.Asp
370
Gly
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3 |
p.Pro
373
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
CL3 |
p.Lys
380
Arg
|
details |
homologous mutations |
1 |
4 |
7 |
N |
N |
? |
CL3 |
p.Lys
380
Ala
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
CL3,NBD1 |
p.Glu
393
Cys
|
details |
homologous mutations |
1 |
9 |
9 |
D |
D |
? |
CL3,NBD1 |
p.Arg
395
Cys
|
details |
homologous mutations |
1 |
2 |
2 |
N |
D |
? |
CL3,NBD1 |
p.Asn
396
Ser
|
details |
homologous mutations |
1 |
1 |
3 |
D |
D |
? |
CL3,NBD1 |
p.Phe
399
Leu
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Ser
400
Asn
|
details |
homologous mutations |
79 |
182 |
201 |
N |
N |
N |
CL3,NBD1 |
p.Ser
400
Ala
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
CL3,NBD1 |
p.Ser
400
Thr
|
details |
homologous mutations |
1 |
4 |
5 |
N |
N |
? |
CL3,NBD1 |
p.Ser
400
Ile
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
CL3,NBD1 |
p.Tyr
401
Trp
|
details |
homologous mutations |
2 |
48 |
62 |
D |
D |
? |
CL3,NBD1 |
p.Tyr
401
Leu
|
details |
homologous mutations |
3 |
11 |
12 |
D |
D |
? |
CL3,NBD1 |
p.Tyr
401
Cys
|
details |
homologous mutations |
2 |
16 |
24 |
D |
D |
? |
CL3,NBD1 |
p.Tyr
401
Ala
|
details |
homologous mutations |
4 |
40 |
66 |
D |
D |
? |
CL3,NBD1 |
p.Tyr
401
Phe
|
details |
homologous mutations |
2 |
9 |
17 |
D |
D |
? |
CL3,NBD1 |
p.Pro
402
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Ser
403
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
CL3,NBD1 |
p.Ile
409
Glu
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Val
417
Ile
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
CL3,NBD1,WA1 |
p.Gly
427
Cys
|
details |
homologous mutations |
4 |
5 |
6 |
D |
D |
? |
CL3,NBD1,WA1 |
p.Asn
428
Cys
|
details |
homologous mutations |
1 |
1 |
2 |
D |
D |
? |
CL3,NBD1,WA1 |
p.Asn
428
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
CL3,NBD1,WA1 |
p.Ser
429
Val
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1,WA1 |
p.Gly
430
Cys
|
details |
homologous mutations |
1 |
3 |
5 |
D |
D |
? |
CL3,NBD1,WA1 |
p.Gly
430
Gln
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1,WA1 |
p.Cys
431
Ala
|
details |
homologous mutations |
4 |
31 |
46 |
N |
D |
? |
CL3,NBD1,WA1 |
p.Cys
431
Ser
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
CL3,NBD1,WA1 |
p.Cys
431
Leu
|
details |
homologous mutations |
3 |
21 |
21 |
D |
D |
? |
CL3,NBD1,WA1 |
p.Cys
431
Phe
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
CL3,NBD1,WA1 |
p.Cys
431
Trp
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
CL3,NBD1,WA1 |
p.Cys
431
Val
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1,WA1 |
p.Gly
432
Cys
|
details |
homologous mutations |
1 |
3 |
5 |
D |
D |
? |
CL3,NBD1,WA1 |
p.Gly
432
Ser
|
details |
homologous mutations |
2 |
3 |
3 |
D |
D |
? |
CL3,NBD1,WA1 |
p.Lys
433
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1,WA1 |
p.Lys
433
Met
|
details |
homologous mutations |
17 |
46 |
56 |
D |
D |
? |
CL3,NBD1,WA1 |
p.Lys
433
Asp
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1,WA1 |
p.Ser
434
Cys
|
details |
homologous mutations |
1 |
1 |
2 |
D |
D |
? |
CL3,NBD1,WA1 |
p.Ser
434
Arg
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Val
437
Ile
|
details |
homologous mutations |
7 |
17 |
51 |
N |
N |
? |
CL3,NBD1 |
p.Val
437
Ala
|
details |
homologous mutations |
1 |
4 |
4 |
N |
D |
? |
CL3,NBD1 |
p.Gln
438
Ile
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Leu
439
Cys
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
CL3,NBD1 |
p.Leu
443
Cys
|
details |
homologous mutations |
3 |
24 |
26 |
N |
D |
? |
CL3,NBD1 |
p.Leu
443
Val
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
CL3,NBD1 |
p.Leu
443
*
|
details |
homologous mutations |
1 |
3 |
3 |
- |
- |
? |
CL3,NBD1 |
p.Leu
443
Ala
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
CL3,NBD1 |
p.Leu
443
Arg
|
details |
homologous mutations |
1 |
4 |
4 |
D |
D |
? |
CL3,NBD1 |
p.Leu
443
Ser
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Leu
443
Phe
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
CL3,NBD1 |
p.Tyr
444
Arg
|
details |
homologous mutations |
2 |
5 |
5 |
D |
D |
? |
CL3,NBD1 |
p.Tyr
444
*
|
details |
homologous mutations |
1 |
3 |
3 |
- |
- |
? |
CL3,NBD1 |
p.Tyr
444
Phe
|
details |
homologous mutations |
1 |
3 |
3 |
D |
D |
? |
CL3,NBD1 |
p.Tyr
444
Glu
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
CL3,NBD1 |
p.Tyr
444
Leu
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
CL3,NBD1 |
p.Tyr
444
Ala
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
CL3,NBD1 |
p.Glu
448
Lys
|
details |
homologous mutations |
2 |
4 |
4 |
N |
D |
? |
CL3,NBD1 |
p.Gly
449
Ala
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
CL3,NBD1 |
p.Met
450
Cys
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
CL3,NBD1 |
p.Ser
452
Cys
|
details |
homologous mutations |
1 |
10 |
10 |
N |
N |
? |
CL3,NBD1 |
p.Gly
455
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Gln
456
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
CL3,NBD1 |
p.Asp
457
Arg
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Phe
465
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
CL3,NBD1 |
p.Arg
467
Lys
|
details |
homologous mutations |
11 |
21 |
23 |
D |
D |
? |
CL3,NBD1 |
p.Arg
467
Ile
|
details |
homologous mutations |
1 |
3 |
5 |
D |
D |
? |
CL3,NBD1 |
p.Ile
469
Cys
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
CL3,NBD1 |
p.Ser
474
Cys
|
details |
homologous mutations |
2 |
13 |
13 |
D |
D |
? |
CL3,NBD1 |
p.Gln
475
Ala
|
details |
homologous mutations |
1 |
20 |
26 |
D |
D |
? |
CL3,NBD1 |
p.Gln
475
Ser
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Ile
488
Cys
|
details |
homologous mutations |
1 |
3 |
3 |
N |
D |
? |
CL3,NBD1 |
p.Arg
489
Cys
|
details |
homologous mutations |
3 |
3 |
3 |
N |
D |
? |
CL3,NBD1 |
p.Tyr
490
Cys
|
details |
homologous mutations |
1 |
2 |
2 |
N |
D |
? |
CL3,NBD1 |
p.Arg
492
Cys
|
details |
homologous mutations |
19 |
47 |
49 |
N |
D |
? |
CL3,NBD1 |
p.Val
495
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
CL3,NBD1 |
p.Asp
498
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
CL3,NBD1 |
p.Ile
500
Cys
|
details |
homologous mutations |
2 |
10 |
10 |
N |
D |
? |
CL3,NBD1 |
p.Glu
501
Gln
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
CL3,NBD1 |
p.Lys
502
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
CL3,NBD1 |
p.Glu
506
Gln
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
CL3,NBD1 |
p.Asn
508
Cys
|
details |
homologous mutations |
2 |
52 |
55 |
D |
D |
? |
CL3,NBD1 |
p.Asn
508
Ile
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Asp
511
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Lys
515
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
D |
? |
CL3,NBD1 |
p.Leu
516
Asp
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Pro
517
Cys
|
details |
homologous mutations |
4 |
43 |
49 |
D |
D |
? |
CL3,NBD1 |
p.Pro
517
Ile
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Pro
517
Phe
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.His
518
Tyr
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
CL3,NBD1 |
p.Lys
519
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
CL3,NBD1 |
p.Asp
521
Pro
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Thr
522
Ser
|
details |
homologous mutations |
5 |
6 |
6 |
D |
D |
? |
CL3,NBD1 |
p.Thr
522
Ile
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Val
524
Asn
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Gly
525
Ser
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Arg
527
Trp
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Ala
529
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Gln
530
Gly
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1,SIG1 |
p.Leu
531
Cys
|
details |
homologous mutations |
4 |
42 |
54 |
D |
D |
? |
CL3,NBD1,SIG1 |
p.Leu
531
Arg
|
details |
homologous mutations |
3 |
10 |
10 |
D |
D |
? |
CL3,NBD1,SIG1 |
p.Leu
531
Lys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1,SIG1 |
p.Ser
532
Arg
|
details |
homologous mutations |
4 |
13 |
15 |
D |
D |
? |
CL3,NBD1,SIG1 |
p.Gly
533
Cys
|
details |
homologous mutations |
1 |
4 |
4 |
D |
D |
? |
CL3,NBD1,SIG1 |
p.Gly
534
Val
|
details |
homologous mutations |
4 |
21 |
21 |
D |
D |
? |
CL3,NBD1,SIG1 |
p.Gly
534
Asp
|
details |
homologous mutations |
7 |
38 |
46 |
D |
D |
? |
CL3,NBD1,SIG1 |
p.Gly
534
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
CL3,NBD1,SIG1 |
p.Gln
535
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
CL3,NBD1,SIG1 |
p.Lys
536
Arg
|
details |
homologous mutations |
7 |
28 |
32 |
D |
D |
? |
CL3,NBD1,SIG1 |
p.Lys
536
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1,SIG1 |
p.Lys
536
Gln
|
details |
homologous mutations |
4 |
13 |
18 |
D |
D |
? |
CL3,NBD1,SIG1 |
p.Lys
536
Ile
|
details |
homologous mutations |
2 |
8 |
9 |
D |
D |
? |
CL3,NBD1,SIG1 |
p.Arg
538
Met
|
details |
homologous mutations |
3 |
11 |
13 |
D |
D |
? |
CL3,NBD1,SIG1 |
p.Ile
541
Phe
|
details |
homologous mutations |
2 |
66 |
73 |
D |
D |
? |
CL3,NBD1,SIG1 |
p.Ile
541
Arg
|
details |
homologous mutations |
2 |
10 |
11 |
D |
D |
? |
CL3,NBD1,SIG1 |
p.Ile
541
Thr
|
details |
homologous mutations |
1 |
8 |
9 |
D |
D |
? |
CL3,NBD1,SIG1 |
p.Arg
543
Ser
|
details |
homologous mutations |
2 |
8 |
9 |
D |
D |
? |
CL3,NBD1,SIG1 |
p.Ala
544
Asp
|
details |
homologous mutations |
1 |
15 |
16 |
D |
D |
? |
CL3,NBD1 |
p.Arg
547
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Pro
549
Cys
|
details |
homologous mutations |
1 |
3 |
3 |
D |
D |
? |
CL3,NBD1,WB1 |
p.Leu
553
Pro
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1,WB1 |
p.Leu
554
Cys
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
CL3,NBD1,WB1 |
p.Asp
555
Asn
|
details |
homologous mutations |
8 |
87 |
113 |
D |
D |
? |
CL3,NBD1,WB1 |
p.Asp
555
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Glu
556
Gln
|
details |
homologous mutations |
16 |
167 |
177 |
N |
D |
? |
CL3,NBD1 |
p.Glu
556
Ala
|
details |
homologous mutations |
5 |
17 |
20 |
D |
D |
? |
CL3,NBD1 |
p.Glu
556
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Glu
556
Thr
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Thr
558
Asp
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Ser
565
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Glu
566
Gln
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Glu
566
Lys
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
CL3,NBD1 |
p.Val
569
Cys
|
details |
homologous mutations |
1 |
3 |
3 |
D |
D |
? |
CL3,NBD1 |
p.Ala
576
Gly
|
details |
homologous mutations |
2 |
12 |
12 |
D |
D |
? |
CL3,NBD1 |
p.Lys
578
Cys
|
details |
homologous mutations |
2 |
12 |
13 |
N |
D |
? |
CL3,NBD1 |
p.Arg
580
Cys
|
details |
homologous mutations |
2 |
3 |
4 |
D |
D |
? |
CL3,NBD1 |
p.Thr
581
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Thr
581
Glu
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Arg
588
Cys
|
details |
homologous mutations |
1 |
3 |
4 |
D |
D |
? |
CL3,NBD1 |
p.Arg
588
Leu
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Thr
591
Cys
|
details |
homologous mutations |
1 |
2 |
10 |
D |
D |
? |
CL3,NBD1 |
p.Arg
593
His
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
CL3,NBD1 |
p.Arg
593
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
CL3,NBD1 |
p.Ala
595
Gly
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
CL3,NBD1 |
p.Ala
599
Thr
|
details |
homologous mutations |
6 |
6 |
6 |
N |
D |
? |
CL3,NBD1 |
p.Phe
601
Asn
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3,NBD1 |
p.Asp
602
Asn
|
details |
homologous mutations |
2 |
3 |
3 |
N |
N |
? |
CL3,NBD1 |
p.Asp
613
Tyr
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
CL3,NBD1 |
p.Thr
627
Glu
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
CL3 |
p.Ala
631
Leu
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
CL3 |
p.Glu
638
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL3 |
p.Ser
644
Arg
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
CL3 |
p.Ser
658
Arg
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
CL3 |
p.Arg
659
Gln
|
details |
homologous mutations |
2 |
4 |
4 |
N |
N |
? |
CL3 |
p.Ser
660
Ala
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
CL3 |
p.Ser
660
Glu
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
CL3 |
p.Ser
661
Glu
|
details |
homologous mutations |
1 |
2 |
4 |
N |
N |
? |
CL3 |
p.Ser
661
Ala
|
details |
homologous mutations |
2 |
4 |
6 |
N |
N |
? |
CL3 |
p.Leu
662
Arg
|
details |
homologous mutations |
10 |
24 |
24 |
N |
N |
? |
CL3 |
p.Lys
665
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
CL3 |
p.Arg
666
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
CL3 |
p.Ser
667
Glu
|
details |
homologous mutations |
1 |
2 |
4 |
N |
N |
? |
CL3 |
p.Ser
667
Ala
|
details |
homologous mutations |
2 |
6 |
8 |
N |
N |
? |
CL3 |
p.Thr
668
Ala
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
CL3 |
p.Thr
668
Glu
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
CL3 |
p.Thr
668
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
CL3 |
p.Arg
669
Cys
|
details |
homologous mutations |
17 |
75 |
89 |
D |
D |
? |
CL3 |
p.Ser
671
Asn
|
details |
homologous mutations |
4 |
5 |
5 |
N |
N |
? |
CL3 |
p.Ser
671
Ala
|
details |
homologous mutations |
3 |
9 |
12 |
N |
N |
? |
CL3 |
p.Ser
671
Glu
|
details |
homologous mutations |
1 |
2 |
4 |
N |
N |
? |
CL3 |
p.Arg
673
Gln
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
CL3 |
p.Ser
675
Glu
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
CL3 |
p.Ser
675
Ala
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
CL3 |
p.Ala
677
Val
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
CL3 |
p.Ser
683
Ala
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
CL3 |
p.Ser
683
Glu
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
CL3 |
p.Thr
684
Ala
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
CL3 |
p.Thr
684
Glu
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
CL3 |
p.Ser
696
Pro
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
CL3 |
p.Glu
707
Ala
|
details |
homologous mutations |
2 |
3 |
4 |
D |
D |
? |
CL3 |
p.Trp
708
Arg
|
details |
homologous mutations |
1 |
3 |
3 |
D |
D |
? |
CL3 |
p.Pro
709
Gly
|
details |
homologous mutations |
3 |
12 |
12 |
N |
D |
? |
CL3 |
p.Pro
709
Ala
|
details |
homologous mutations |
4 |
11 |
11 |
N |
D |
? |
CL3 |
p.Tyr
710
Ala
|
details |
homologous mutations |
1 |
6 |
6 |
D |
D |
? |
CL3 |
p.Phe
711
Cys
|
details |
homologous mutations |
2 |
3 |
3 |
N |
D |
? |
CL3 |
p.Val
712
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
D |
? |
CL3 |
p.Val
713
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
D |
? |
CL3 |
p.Gly
714
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
CL3 |
p.Gly
714
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH7 |
p.Val
715
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
N |
? |
TMD2,TH7 |
p.Val
715
Ala
|
details |
homologous mutations |
1 |
3 |
3 |
N |
N |
? |
TMD2,TH7 |
p.Phe
716
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
D |
? |
TMD2,TH7 |
p.Phe
716
Ala
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
TMD2,TH7 |
p.Cys
717
Ser
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD2,TH7 |
p.Ala
718
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
D |
? |
TMD2,TH7 |
p.Ala
718
Leu
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH7 |
p.Ile
719
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
D |
? |
TMD2,TH7 |
p.Ile
719
Ala
|
details |
homologous mutations |
1 |
3 |
3 |
N |
N |
? |
TMD2,TH7 |
p.Ile
720
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
D |
? |
TMD2,TH7 |
p.Asn
721
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
D |
? |
TMD2,TH7 |
p.Gly
722
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
TMD2,TH7 |
p.Gly
722
Ala
|
details |
homologous mutations |
2 |
6 |
6 |
D |
D |
? |
TMD2,TH7 |
p.Gly
723
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
D |
? |
TMD2,TH7 |
p.Gly
723
Glu
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD2,TH7 |
p.Gly
723
Ala
|
details |
homologous mutations |
1 |
3 |
3 |
N |
N |
? |
TMD2,TH7 |
p.Leu
724
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD2,TH7 |
p.Gln
725
Cys
|
details |
homologous mutations |
2 |
47 |
60 |
N |
D |
? |
TMD2,TH7 |
p.Pro
726
Cys
|
details |
homologous mutations |
1 |
5 |
5 |
N |
D |
? |
TMD2,TH7 |
p.Pro
726
Thr
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD2,TH7 |
p.Ala
727
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD2,TH7 |
p.Phe
728
Cys
|
details |
homologous mutations |
4 |
41 |
55 |
N |
D |
? |
TMD2,TH7 |
p.Phe
728
Ala
|
details |
homologous mutations |
2 |
13 |
13 |
D |
D |
? |
TMD2,TH7 |
p.Ala
729
Cys
|
details |
homologous mutations |
1 |
12 |
12 |
N |
N |
? |
TMD2,TH7 |
p.Ile
731
Cys
|
details |
homologous mutations |
1 |
2 |
2 |
N |
D |
? |
TMD2,TH7 |
p.Ile
736
Lys
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
TMD2,EL4 |
p.Arg
741
Cys
|
details |
homologous mutations |
3 |
143 |
169 |
N |
N |
? |
TMD2,EL4 |
p.Asp
743
Arg
|
details |
homologous mutations |
2 |
5 |
5 |
N |
N |
? |
TMD2,EL4 |
p.Asp
744
Arg
|
details |
homologous mutations |
1 |
4 |
4 |
D |
D |
? |
TMD2,EL4 |
p.Asp
744
Pro
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH8 |
p.Ala
761
Ser
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD2,TH8 |
p.Ile
764
Ala
|
details |
homologous mutations |
1 |
4 |
4 |
N |
N |
? |
TMD2,TH8 |
p.Ile
765
Ala
|
details |
homologous mutations |
1 |
5 |
5 |
N |
D |
? |
TMD2,TH8 |
p.Ser
766
Thr
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD2,TH8 |
p.Phe
767
Cys
|
details |
homologous mutations |
1 |
4 |
5 |
N |
D |
? |
TMD2,TH8 |
p.Ile
768
Cys
|
details |
homologous mutations |
1 |
1 |
2 |
N |
D |
? |
TMD2,TH8 |
p.Ile
768
Ala
|
details |
homologous mutations |
1 |
3 |
3 |
N |
N |
? |
TMD2,TH8 |
p.Thr
769
Cys
|
details |
homologous mutations |
2 |
2 |
7 |
N |
D |
? |
TMD2,TH8 |
p.Phe
770
Cys
|
details |
homologous mutations |
3 |
27 |
49 |
N |
D |
? |
TMD2,TH8 |
p.Phe
770
Ala
|
details |
homologous mutations |
1 |
3 |
3 |
N |
D |
? |
TMD2,TH8 |
p.Phe
771
Cys
|
details |
homologous mutations |
2 |
7 |
12 |
N |
D |
? |
TMD2,TH8 |
p.Leu
772
Cys
|
details |
homologous mutations |
2 |
2 |
3 |
N |
D |
? |
TMD2,TH8 |
p.Leu
772
Ala
|
details |
homologous mutations |
1 |
4 |
4 |
N |
D |
? |
TMD2,TH8 |
p.Gln
773
Cys
|
details |
homologous mutations |
2 |
3 |
4 |
D |
D |
? |
TMD2,TH8 |
p.Gln
773
Arg
|
details |
homologous mutations |
3 |
39 |
46 |
D |
D |
? |
TMD2,TH8 |
p.Gln
773
Ala
|
details |
homologous mutations |
2 |
5 |
9 |
D |
D |
? |
TMD2,TH8 |
p.Gly
774
Cys
|
details |
homologous mutations |
3 |
24 |
48 |
D |
D |
? |
TMD2,TH8 |
p.Gly
774
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH8 |
p.Phe
775
Cys
|
details |
homologous mutations |
2 |
6 |
8 |
N |
D |
? |
TMD2,TH8 |
p.Thr
776
Cys
|
details |
homologous mutations |
2 |
2 |
3 |
N |
N |
? |
TMD2,TH8 |
p.Phe
777
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH8 |
p.Phe
777
Ala
|
details |
homologous mutations |
1 |
1 |
2 |
D |
D |
? |
TMD2,TH8 |
p.Gly
778
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,CL4 |
p.Lys
779
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,CL4 |
p.Ala
780
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD2,CL4 |
p.Gly
781
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,CL4 |
p.Glu
782
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,CL4 |
p.Ile
783
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD2,CL4 |
p.Arg
787
Trp
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD2,CL4 |
p.Tyr
790
Ala
|
details |
homologous mutations |
1 |
4 |
5 |
N |
N |
? |
TMD2,CL4 |
p.Phe
793
Ala
|
details |
homologous mutations |
1 |
6 |
6 |
D |
D |
? |
TMD2,CL4 |
p.Leu
797
Ala
|
details |
homologous mutations |
1 |
6 |
6 |
D |
D |
? |
TMD2,CL4 |
p.Asp
800
Asn
|
details |
homologous mutations |
3 |
3 |
3 |
D |
D |
? |
TMD2,CL4 |
p.Asp
800
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,CL4 |
p.Val
801
Met
|
details |
homologous mutations |
5 |
5 |
5 |
N |
N |
? |
TMD2,CL4 |
p.Val
801
Ser
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
TMD2,CL4 |
p.Ser
802
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD2,CL4 |
p.Ser
802
Thr
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD2,CL4 |
p.Trp
803
Ala
|
details |
homologous mutations |
2 |
8 |
10 |
D |
D |
? |
TMD2,CL4 |
p.Trp
803
Cys
|
details |
homologous mutations |
5 |
19 |
19 |
D |
D |
? |
TMD2,CL4 |
p.Trp
803
Phe
|
details |
homologous mutations |
1 |
2 |
2 |
N |
D |
? |
TMD2,CL4 |
p.Trp
803
Leu
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD2,CL4 |
p.Trp
803
Ser
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,CL4 |
p.Trp
803
Tyr
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD2,CL4 |
p.Trp
803
Asp
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,CL4 |
p.Trp
803
Thr
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,CL4 |
p.Phe
804
Ala
|
details |
homologous mutations |
2 |
11 |
13 |
D |
D |
? |
TMD2,CL4 |
p.Phe
804
Ser
|
details |
homologous mutations |
1 |
2 |
3 |
D |
D |
? |
TMD2,CL4 |
p.Phe
804
Tyr
|
details |
homologous mutations |
1 |
2 |
3 |
N |
N |
? |
TMD2,CL4 |
p.Phe
804
Leu
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD2,CL4 |
p.Phe
804
Trp
|
details |
homologous mutations |
1 |
1 |
2 |
D |
D |
? |
TMD2,CL4 |
p.Phe
804
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,CL4 |
p.Phe
804
Gln
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,CL4 |
p.Phe
804
Asp
|
details |
homologous mutations |
2 |
10 |
10 |
D |
D |
? |
TMD2,CL4 |
p.Asp
805
Cys
|
details |
homologous mutations |
2 |
99 |
126 |
D |
D |
? |
TMD2,CL4 |
p.Asp
805
Asn
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD2,CL4 |
p.Asp
805
Ala
|
details |
homologous mutations |
2 |
3 |
4 |
D |
D |
? |
TMD2,CL4 |
p.Asn
809
Gln
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,CL4 |
p.Thr
811
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,CL4 |
p.Gly
812
Val
|
details |
homologous mutations |
3 |
3 |
4 |
D |
D |
? |
TMD2,CL4 |
p.Leu
814
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,CL4 |
p.Leu
818
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,CL4 |
p.Asn
820
Cys
|
details |
homologous mutations |
7 |
122 |
149 |
D |
N |
? |
TMD2,CL4 |
p.Asp
821
Cys
|
details |
homologous mutations |
1 |
1 |
2 |
D |
D |
? |
TMD2,CL4 |
p.Ala
822
Cys
|
details |
homologous mutations |
1 |
1 |
2 |
N |
D |
? |
TMD2,CL4 |
p.Ala
828
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD2,CL4 |
p.Ile
829
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
N |
? |
TMD2,CL4 |
p.Ile
829
Val
|
details |
homologous mutations |
3 |
4 |
4 |
D |
N |
? |
TMD2,CL4 |
p.Gly
830
Val
|
details |
homologous mutations |
7 |
12 |
13 |
D |
D |
? |
TMD2,CL4 |
p.Gly
830
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,CL4 |
p.Ser
831
Cys
|
details |
homologous mutations |
2 |
3 |
3 |
N |
N |
? |
TMD2,CL4 |
p.Arg
832
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH9 |
p.Leu
833
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH9 |
p.Ala
834
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH9 |
p.Val
835
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD2,TH9 |
p.Ile
836
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD2,TH9 |
p.Ile
836
Val
|
details |
homologous mutations |
2 |
2 |
2 |
D |
N |
? |
TMD2,TH9 |
p.Thr
837
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
N |
? |
TMD2,TH9 |
p.Thr
837
Ala
|
details |
homologous mutations |
1 |
3 |
3 |
N |
N |
? |
TMD2,TH9 |
p.Gln
838
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH9 |
p.Asn
839
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH9 |
p.Asn
839
Ile
|
details |
homologous mutations |
2 |
5 |
5 |
D |
D |
? |
TMD2,TH9 |
p.Ile
840
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD2,TH9 |
p.Ile
840
Ala
|
details |
homologous mutations |
1 |
2 |
2 |
N |
D |
? |
TMD2,TH9 |
p.Ala
841
Cys
|
details |
homologous mutations |
2 |
3 |
3 |
N |
N |
? |
TMD2,TH9 |
p.Ala
841
Leu
|
details |
homologous mutations |
4 |
7 |
7 |
D |
D |
? |
TMD2,TH9 |
p.Ile
849
Met
|
details |
homologous mutations |
12 |
43 |
43 |
N |
D |
? |
TMD2,TH9 |
p.Ser
850
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH9 |
p.Tyr
853
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD2,TH9 |
p.Gly
854
Val
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH9 |
p.Gly
854
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH9 |
p.Trp
855
Arg
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH9 |
p.Trp
855
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,EL5 |
p.Leu
859
Trp
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH10 |
p.Leu
860
Phe
|
details |
homologous mutations |
2 |
2 |
2 |
N |
D |
? |
TMD2,TH10 |
p.Ala
863
Gly
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD2,TH10 |
p.Ile
864
Ala
|
details |
homologous mutations |
1 |
5 |
5 |
N |
D |
? |
TMD2,TH10 |
p.Val
865
Arg
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD2,TH10 |
p.Pro
866
Ala
|
details |
homologous mutations |
6 |
7 |
8 |
D |
D |
? |
TMD2,TH10 |
p.Ile
867
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD2,TH10 |
p.Ile
867
Ala
|
details |
homologous mutations |
1 |
3 |
3 |
N |
D |
? |
TMD2,TH10 |
p.Ile
868
Cys
|
details |
homologous mutations |
2 |
3 |
3 |
N |
D |
? |
TMD2,TH10 |
p.Ile
868
Arg
|
details |
homologous mutations |
1 |
4 |
5 |
D |
D |
? |
TMD2,TH10 |
p.Ala
869
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD2,TH10 |
p.Ile
870
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD2,TH10 |
p.Ala
871
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD2,TH10 |
p.Ala
871
Phe
|
details |
homologous mutations |
1 |
5 |
5 |
D |
D |
? |
TMD2,TH10 |
p.Gly
872
Cys
|
details |
homologous mutations |
2 |
3 |
3 |
D |
D |
? |
TMD2,TH10 |
p.Gly
872
Arg
|
details |
homologous mutations |
2 |
4 |
4 |
D |
D |
? |
TMD2,TH10 |
p.Val
873
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD2,TH10 |
p.Val
874
Cys
|
details |
homologous mutations |
1 |
5 |
5 |
N |
D |
? |
TMD2,TH10 |
p.Glu
875
Cys
|
details |
homologous mutations |
3 |
32 |
32 |
D |
D |
? |
TMD2,TH10 |
p.Glu
875
Ala
|
details |
homologous mutations |
1 |
10 |
10 |
D |
D |
? |
TMD2,TH10 |
p.Glu
875
Arg
|
details |
homologous mutations |
1 |
3 |
4 |
D |
D |
? |
TMD2,TH10 |
p.Met
876
Cys
|
details |
homologous mutations |
1 |
4 |
4 |
D |
D |
? |
TMD2,TH10 |
p.Lys
877
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH10 |
p.Met
878
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD2,TH10 |
p.Leu
879
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,CL5 |
p.Ser
893
Ala
|
details |
homologous mutations |
21 |
35 |
38 |
N |
N |
N |
TMD2,CL5 |
p.Ser
893
Thr
|
details |
homologous mutations |
6 |
9 |
10 |
D |
N |
N |
TMD2,CL5 |
p.Gly
894
Thr
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,CL5 |
p.Phe
904
Cys
|
details |
homologous mutations |
1 |
6 |
6 |
N |
D |
? |
TMD2,CL5 |
p.Arg
905
Cys
|
details |
homologous mutations |
2 |
13 |
13 |
D |
D |
? |
TMD2,CL5 |
p.Arg
905
Thr
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,CL5 |
p.Arg
905
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,CL5 |
p.Val
907
Ile
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
TMD2,CL5 |
p.Ser
909
Cys
|
details |
homologous mutations |
2 |
31 |
34 |
D |
D |
? |
TMD2,TH11 |
p.Ala
935
Cys
|
details |
homologous mutations |
5 |
28 |
33 |
D |
D |
? |
TMD2,TH11 |
p.His
936
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
TMD2,TH11 |
p.Ile
937
Ser
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH11 |
p.Ile
937
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
D |
? |
TMD2,TH11 |
p.Phe
938
Ala
|
details |
homologous mutations |
5 |
7 |
8 |
N |
D |
? |
TMD2,TH11 |
p.Phe
938
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
TMD2,TH11 |
p.Gly
939
Val
|
details |
homologous mutations |
1 |
12 |
12 |
D |
D |
? |
TMD2,TH11 |
p.Gly
939
Cys
|
details |
homologous mutations |
4 |
18 |
18 |
D |
D |
? |
TMD2,TH11 |
p.Ile
940
Ser
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD2,TH11 |
p.Ile
940
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
D |
? |
TMD2,TH11 |
p.Thr
941
Ala
|
details |
homologous mutations |
5 |
7 |
8 |
N |
N |
? |
TMD2,TH11 |
p.Thr
941
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
N |
? |
TMD2,TH11 |
p.Thr
941
Gly
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD2,TH11 |
p.Phe
942
Ala
|
details |
homologous mutations |
3 |
21 |
21 |
D |
D |
? |
TMD2,TH11 |
p.Phe
942
Cys
|
details |
homologous mutations |
6 |
17 |
19 |
D |
D |
? |
TMD2,TH11 |
p.Phe
942
Arg
|
details |
homologous mutations |
2 |
6 |
6 |
D |
D |
? |
TMD2,TH11 |
p.Ser
943
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD2,TH11 |
p.Ser
943
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
D |
? |
TMD2,TH11 |
p.Phe
944
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH11 |
p.Phe
944
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
N |
D |
? |
TMD2,TH11 |
p.Thr
945
Ala
|
details |
homologous mutations |
5 |
29 |
29 |
N |
N |
? |
TMD2,TH11 |
p.Thr
945
Cys
|
details |
homologous mutations |
6 |
20 |
22 |
D |
N |
? |
TMD2,TH11 |
p.Thr
945
Arg
|
details |
homologous mutations |
2 |
21 |
23 |
D |
N |
? |
TMD2,TH11 |
p.Thr
945
Glu
|
details |
homologous mutations |
1 |
3 |
4 |
D |
N |
? |
TMD2,TH11 |
p.Gln
946
Ala
|
details |
homologous mutations |
2 |
6 |
6 |
D |
D |
? |
TMD2,TH11 |
p.Gln
946
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH11 |
p.Gln
946
Arg
|
details |
homologous mutations |
1 |
4 |
4 |
D |
D |
? |
TMD2,TH11 |
p.Ala
947
Leu
|
details |
homologous mutations |
1 |
7 |
7 |
D |
D |
? |
TMD2,TH11 |
p.Ala
947
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD2,TH11 |
p.Ala
947
Val
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH11 |
p.Met
948
Ala
|
details |
homologous mutations |
3 |
5 |
5 |
N |
D |
? |
TMD2,TH11 |
p.Met
948
Ile
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
TMD2,TH11 |
p.Met
949
Ala
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
TMD2,TH11 |
p.Met
949
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH11 |
p.Met
949
Arg
|
details |
homologous mutations |
1 |
3 |
3 |
D |
D |
? |
TMD2,TH11 |
p.Tyr
950
Ala
|
details |
homologous mutations |
2 |
10 |
10 |
D |
D |
? |
TMD2,TH11 |
p.Tyr
950
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
TMD2,TH11 |
p.Tyr
950
Phe
|
details |
homologous mutations |
2 |
26 |
38 |
N |
N |
? |
TMD2,TH11 |
p.Tyr
950
Arg
|
details |
homologous mutations |
1 |
4 |
4 |
D |
D |
? |
TMD2,TH11 |
p.Phe
951
Ala
|
details |
homologous mutations |
2 |
2 |
2 |
N |
D |
? |
TMD2,TH11 |
p.Ser
952
Ala
|
details |
homologous mutations |
2 |
2 |
2 |
N |
N |
? |
TMD2,TH11 |
p.Ser
952
Arg
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD2,TH11 |
p.Tyr
953
Ala
|
details |
homologous mutations |
3 |
17 |
17 |
D |
D |
? |
TMD2,TH11 |
p.Tyr
953
Cys
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD2,TH11 |
p.Tyr
953
Phe
|
details |
homologous mutations |
2 |
28 |
40 |
N |
D |
? |
TMD2,TH11 |
p.Tyr
953
Arg
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
TMD2,TH11 |
p.Ala
954
Leu
|
details |
homologous mutations |
1 |
5 |
5 |
D |
D |
? |
TMD2,TH11 |
p.Ala
954
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD2,TH11 |
p.Gly
955
Val
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD2,TH11 |
p.Cys
956
Ala
|
details |
homologous mutations |
1 |
2 |
2 |
N |
D |
? |
TMD2,TH11 |
p.Cys
956
Ser
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
TMD2,TH11 |
p.Phe
957
Ala
|
details |
homologous mutations |
2 |
5 |
5 |
N |
D |
? |
TMD2,TH11 |
p.Phe
957
Cys
|
details |
homologous mutations |
1 |
3 |
3 |
N |
D |
? |
TMD2,TH12 |
p.Leu
975
Ala
|
details |
homologous mutations |
7 |
46 |
78 |
D |
D |
? |
TMD2,TH12 |
p.Leu
975
Cys
|
details |
homologous mutations |
14 |
54 |
62 |
N |
D |
? |
TMD2,TH12 |
p.Leu
976
Cys
|
details |
homologous mutations |
3 |
25 |
25 |
N |
D |
? |
TMD2,TH12 |
p.Phe
978
Ala
|
details |
homologous mutations |
10 |
16 |
19 |
D |
D |
? |
TMD2,TH12 |
p.Phe
978
Ser
|
details |
homologous mutations |
2 |
4 |
4 |
N |
D |
? |
TMD2,TH12 |
p.Phe
978
Cys
|
details |
homologous mutations |
4 |
33 |
33 |
N |
D |
? |
TMD2,TH12 |
p.Phe
978
Tyr
|
details |
homologous mutations |
1 |
1 |
1 |
D |
N |
? |
TMD2,TH12 |
p.Phe
978
Leu
|
details |
homologous mutations |
2 |
4 |
4 |
N |
D |
? |
TMD2,TH12 |
p.Phe
978
Arg
|
details |
homologous mutations |
1 |
3 |
3 |
D |
D |
? |
TMD2,TH12 |
p.Ser
979
Cys
|
details |
homologous mutations |
2 |
6 |
6 |
D |
D |
? |
TMD2,TH12 |
p.Ala
980
Cys
|
details |
homologous mutations |
2 |
20 |
21 |
N |
D |
? |
TMD2,TH12 |
p.Val
981
Ala
|
details |
homologous mutations |
5 |
37 |
69 |
D |
D |
? |
TMD2,TH12 |
p.Val
981
Cys
|
details |
homologous mutations |
3 |
5 |
6 |
D |
D |
? |
TMD2,TH12 |
p.Val
982
Cys
|
details |
homologous mutations |
13 |
68 |
108 |
D |
D |
? |
TMD2,TH12 |
p.Val
982
Arg
|
details |
homologous mutations |
2 |
4 |
4 |
D |
D |
? |
TMD2,TH12 |
p.Val
982
Ala
|
details |
homologous mutations |
2 |
19 |
19 |
N |
D |
? |
TMD2,TH12 |
p.Phe
983
Ala
|
details |
homologous mutations |
19 |
215 |
301 |
D |
D |
? |
TMD2,TH12 |
p.Phe
983
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH12 |
p.Gly
984
Cys
|
details |
homologous mutations |
5 |
22 |
24 |
D |
D |
? |
TMD2,TH12 |
p.Ala
985
Cys
|
details |
homologous mutations |
2 |
12 |
13 |
D |
D |
? |
TMD2,TH12 |
p.Ala
985
Thr
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH12 |
p.Met
986
Ala
|
details |
homologous mutations |
5 |
26 |
31 |
D |
D |
? |
TMD2,TH12 |
p.Met
986
Val
|
details |
homologous mutations |
28 |
61 |
62 |
N |
N |
? |
TMD2,TH12 |
p.Met
986
Cys
|
details |
homologous mutations |
5 |
29 |
31 |
D |
D |
? |
TMD2,TH12 |
p.Met
986
Arg
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH12 |
p.Ala
987
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH12 |
p.Val
988
Ala
|
details |
homologous mutations |
5 |
24 |
29 |
N |
D |
? |
TMD2,TH12 |
p.Val
988
Cys
|
details |
homologous mutations |
2 |
22 |
22 |
D |
D |
? |
TMD2,TH12 |
p.Gly
989
Cys
|
details |
homologous mutations |
6 |
33 |
33 |
D |
D |
? |
TMD2,TH12 |
p.Gln
990
Ala
|
details |
homologous mutations |
6 |
26 |
31 |
D |
D |
? |
TMD2,TH12 |
p.Gln
990
Cys
|
details |
homologous mutations |
2 |
12 |
12 |
D |
D |
? |
TMD2,TH12 |
p.Val
991
Ala
|
details |
homologous mutations |
5 |
21 |
26 |
N |
N |
? |
TMD2,TH12 |
p.Val
991
Cys
|
details |
homologous mutations |
2 |
7 |
7 |
N |
N |
? |
TMD2,TH12 |
p.Ser
992
Asn
|
details |
homologous mutations |
1 |
1 |
1 |
D |
N |
? |
TMD2,TH12 |
p.Ser
992
Cys
|
details |
homologous mutations |
2 |
7 |
7 |
D |
D |
? |
TMD2,TH12 |
p.Ser
992
Ala
|
details |
homologous mutations |
1 |
2 |
2 |
D |
N |
? |
TMD2,TH12 |
p.Ser
993
Cys
|
details |
homologous mutations |
6 |
37 |
58 |
D |
D |
? |
TMD2,TH12 |
p.Ser
993
Ala
|
details |
homologous mutations |
1 |
2 |
2 |
D |
N |
? |
TMD2,TH12 |
p.Ser
993
Arg
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
TMD2,TH12 |
p.Phe
994
Cys
|
details |
homologous mutations |
2 |
11 |
11 |
D |
D |
? |
TMD2,TH12 |
p.Pro
996
Gln
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
CL6 |
p.Ala
999
Thr
|
details |
homologous mutations |
23 |
58 |
58 |
N |
D |
? |
CL6 |
p.Ala
999
Trp
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6 |
p.Ala
1005
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
CL6 |
p.Glu
1013
Gly
|
details |
homologous mutations |
1 |
3 |
6 |
D |
D |
? |
CL6 |
p.Glu
1013
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
CL6 |
p.Thr
1015
Ala
|
details |
homologous mutations |
2 |
3 |
3 |
N |
N |
? |
CL6 |
p.Pro
1028
Gln
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
CL6 |
p.Leu
1031
Met
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
CL6,NBD2 |
p.Thr
1036
Ala
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
CL6,NBD2 |
p.Asn
1043
Glu
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
CL6,NBD2 |
p.Tyr
1044
Ala
|
details |
homologous mutations |
4 |
33 |
55 |
D |
D |
? |
CL6,NBD2 |
p.Tyr
1044
Trp
|
details |
homologous mutations |
2 |
11 |
26 |
D |
D |
? |
CL6,NBD2 |
p.Tyr
1044
Phe
|
details |
homologous mutations |
2 |
9 |
17 |
D |
D |
? |
CL6,NBD2 |
p.Tyr
1044
Cys
|
details |
homologous mutations |
1 |
8 |
13 |
D |
D |
? |
CL6,NBD2 |
p.Tyr
1044
Ile
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Pro
1045
His
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Ile
1050
Thr
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
CL6,NBD2 |
p.Ile
1050
Cys
|
details |
homologous mutations |
4 |
42 |
48 |
N |
D |
? |
CL6,NBD2 |
p.Pro
1051
Ala
|
details |
homologous mutations |
13 |
47 |
47 |
D |
D |
? |
CL6,NBD2 |
p.Val
1052
Ile
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |
CL6,NBD2 |
p.Lys
1061
Arg
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
CL6,NBD2 |
p.Gly
1063
Ala
|
details |
homologous mutations |
7 |
31 |
31 |
D |
D |
? |
CL6,NBD2 |
p.Thr
1065
Gly
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2,WA2 |
p.Gly
1070
Cys
|
details |
homologous mutations |
1 |
4 |
4 |
D |
D |
? |
CL6,NBD2,WA2 |
p.Ser
1071
Cys
|
details |
homologous mutations |
1 |
3 |
3 |
D |
D |
? |
CL6,NBD2,WA2 |
p.Ser
1072
Cys
|
details |
homologous mutations |
1 |
5 |
6 |
D |
D |
? |
CL6,NBD2,WA2 |
p.Gly
1073
Cys
|
details |
homologous mutations |
2 |
12 |
14 |
D |
D |
? |
CL6,NBD2,WA2 |
p.Gly
1073
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2,WA2 |
p.Cys
1074
Ser
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2,WA2 |
p.Cys
1074
Trp
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
CL6,NBD2,WA2 |
p.Cys
1074
Ala
|
details |
homologous mutations |
2 |
18 |
22 |
D |
D |
? |
CL6,NBD2,WA2 |
p.Gly
1075
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2,WA2 |
p.Gly
1075
Ser
|
details |
homologous mutations |
2 |
3 |
3 |
D |
D |
? |
CL6,NBD2,WA2 |
p.Lys
1076
Cys
|
details |
homologous mutations |
1 |
3 |
3 |
D |
D |
? |
CL6,NBD2,WA2 |
p.Lys
1076
Met
|
details |
homologous mutations |
17 |
39 |
47 |
D |
D |
? |
CL6,NBD2,WA2 |
p.Ser
1077
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2,WA2 |
p.Ser
1077
Gly
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2,WA2 |
p.Ser
1077
Phe
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Thr
1078
Ile
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Gln
1081
Leu
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Arg
1085
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Phe
1086
Cys
|
details |
homologous mutations |
6 |
22 |
25 |
D |
D |
? |
CL6,NBD2 |
p.Phe
1086
Ala
|
details |
homologous mutations |
3 |
46 |
52 |
D |
D |
? |
CL6,NBD2 |
p.Phe
1086
Asp
|
details |
homologous mutations |
1 |
5 |
5 |
D |
D |
? |
CL6,NBD2 |
p.Phe
1086
Arg
|
details |
homologous mutations |
2 |
9 |
9 |
D |
D |
? |
CL6,NBD2 |
p.Phe
1086
Trp
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
CL6,NBD2 |
p.Phe
1086
Leu
|
details |
homologous mutations |
3 |
4 |
4 |
D |
D |
? |
CL6,NBD2 |
p.Phe
1086
Tyr
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
CL6,NBD2 |
p.Phe
1086
*
|
details |
homologous mutations |
2 |
4 |
4 |
- |
- |
? |
CL6,NBD2 |
p.Tyr
1087
Cys
|
details |
homologous mutations |
2 |
4 |
4 |
D |
D |
? |
CL6,NBD2 |
p.Tyr
1087
Ala
|
details |
homologous mutations |
2 |
11 |
11 |
D |
D |
? |
CL6,NBD2 |
p.Tyr
1087
Leu
|
details |
homologous mutations |
1 |
10 |
10 |
D |
D |
? |
CL6,NBD2 |
p.Tyr
1087
Phe
|
details |
homologous mutations |
1 |
7 |
7 |
D |
D |
? |
CL6,NBD2 |
p.Tyr
1087
Asp
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Tyr
1087
Pro
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Tyr
1087
Arg
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Asp
1088
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Asp
1088
Asn
|
details |
homologous mutations |
3 |
4 |
4 |
D |
D |
? |
CL6,NBD2 |
p.Gly
1092
Glu
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
CL6,NBD2 |
p.Gly
1098
Ala
|
details |
homologous mutations |
3 |
4 |
4 |
D |
D |
? |
CL6,NBD2 |
p.Lys
1099
Glu
|
details |
homologous mutations |
2 |
2 |
2 |
N |
N |
? |
CL6,NBD2 |
p.Gln
1107
Pro
|
details |
homologous mutations |
21 |
28 |
29 |
D |
D |
? |
CL6,NBD2 |
p.Trp
1108
Arg
|
details |
homologous mutations |
11 |
38 |
49 |
D |
D |
? |
CL6,NBD2 |
p.Leu
1109
Phe
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Gln
1118
Ala
|
details |
homologous mutations |
3 |
39 |
45 |
D |
D |
? |
CL6,NBD2 |
p.Cys
1125
Ser
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Ser
1137
Ile
|
details |
homologous mutations |
2 |
2 |
2 |
N |
D |
? |
CL6,NBD2 |
p.Ser
1141
Thr
|
details |
homologous mutations |
30 |
66 |
76 |
N |
N |
? |
CL6,NBD2 |
p.Glu
1144
Lys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Ile
1145
Met
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
CL6,NBD2 |
p.Phe
1157
Val
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Ile
1158
Gln
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Leu
1161
Gly
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Lys
1164
Val
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Thr
1167
Arg
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Lys
1168
Glu
|
details |
homologous mutations |
2 |
2 |
2 |
N |
N |
? |
CL6,NBD2,SIG2 |
p.Leu
1176
Cys
|
details |
homologous mutations |
3 |
24 |
28 |
D |
D |
? |
CL6,NBD2,SIG2 |
p.Ser
1177
Cys
|
details |
homologous mutations |
1 |
4 |
9 |
D |
D |
? |
CL6,NBD2,SIG2 |
p.Gly
1178
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2,SIG2 |
p.Gly
1179
Asp
|
details |
homologous mutations |
1 |
14 |
18 |
D |
D |
? |
CL6,NBD2,SIG2 |
p.Gly
1179
Cys
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
CL6,NBD2,SIG2 |
p.Gln
1180
Cys
|
details |
homologous mutations |
2 |
2 |
2 |
D |
D |
? |
CL6,NBD2 |
p.Pro
1194
Ala
|
details |
homologous mutations |
2 |
4 |
4 |
D |
D |
? |
CL6,NBD2 |
p.His
1195
Tyr
|
details |
homologous mutations |
1 |
28 |
33 |
N |
N |
? |
CL6,NBD2,WB2 |
p.Ile
1196
Ser
|
details |
homologous mutations |
5 |
43 |
57 |
D |
D |
? |
CL6,NBD2,WB2 |
p.Ile
1196
Tyr
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
CL6,NBD2,WB2 |
p.Asp
1200
Asn
|
details |
homologous mutations |
5 |
61 |
81 |
D |
D |
? |
CL6,NBD2,WB2 |
p.Asp
1200
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Glu
1201
Gln
|
details |
homologous mutations |
15 |
162 |
171 |
D |
D |
? |
CL6,NBD2 |
p.Glu
1201
Ala
|
details |
homologous mutations |
5 |
16 |
19 |
D |
D |
? |
CL6,NBD2 |
p.Glu
1201
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Thr
1203
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Glu
1211
Ala
|
details |
homologous mutations |
3 |
3 |
3 |
D |
D |
? |
CL6,NBD2 |
p.Val
1214
Ile
|
details |
homologous mutations |
1 |
2 |
2 |
N |
N |
? |
CL6,NBD2 |
p.Gln
1215
Asp
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
CL6,NBD2 |
p.Glu
1223
Asp
|
details |
homologous mutations |
2 |
2 |
2 |
N |
N |
? |
CL6,NBD2 |
p.Thr
1226
Cys
|
details |
homologous mutations |
1 |
8 |
8 |
D |
D |
? |
CL6,NBD2 |
p.Cys
1227
Ser
|
details |
homologous mutations |
1 |
1 |
1 |
N |
D |
? |
CL6,NBD2 |
p.Thr
1236
Cys
|
details |
homologous mutations |
32 |
107 |
116 |
D |
D |
? |
CL6,NBD2 |
p.Gly
1249
Ala
|
details |
homologous mutations |
37 |
125 |
136 |
D |
D |
? |
CL6,NBD2 |
p.Gly
1249
Cys
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Val
1251
Ile
|
details |
homologous mutations |
18 |
50 |
52 |
N |
N |
? |
CL6,NBD2 |
p.Thr
1256
Lys
|
details |
homologous mutations |
7 |
11 |
11 |
D |
D |
? |
CL6,NBD2 |
p.Leu
1260
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Leu
1261
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
D |
D |
? |
CL6,NBD2 |
p.Lys
1264
Ala
|
details |
homologous mutations |
1 |
2 |
2 |
D |
D |
? |
CL6,NBD2 |
p.Gly
1265
Ser
|
details |
homologous mutations |
2 |
5 |
6 |
D |
D |
? |
CL6,NBD2 |
p.Phe
1268
Ala
|
details |
homologous mutations |
1 |
3 |
3 |
D |
D |
? |
CL6 |
p.Gln
1280
Ala
|
details |
homologous mutations |
1 |
1 |
1 |
N |
N |
? |