ABCB1 p.Thr1236Cys

Predicted by SNAP2: A: D (75%), C: D (80%), D: D (91%), E: D (91%), F: D (91%), G: D (85%), H: D (85%), I: D (85%), K: D (91%), L: D (85%), M: D (85%), N: D (85%), P: D (91%), Q: D (85%), R: D (91%), S: D (59%), V: D (85%), W: D (91%), Y: D (91%),
Predicted by PROVEAN: A: D, C: D, D: D, E: D, F: D, G: D, H: D, I: D, K: D, L: D, M: D, N: D, P: D, Q: D, R: D, S: D, V: D, W: D, Y: D,

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[hide] Ito S, Ieiri I, Tanabe M, Suzuki A, Higuchi S, Otsubo K
Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects.
Pharmacogenetics. 2001 Mar;11(2):175-84., [PMID:11266082]

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[hide] Obata H, Yahata T, Quan J, Sekine M, Tanaka K
Association between single nucleotide polymorphisms of drug resistance-associated genes and response to chemotherapy in advanced ovarian cancer.
Anticancer Res. 2006 May-Jun;26(3B):2227-32., [PMID:16821592]

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[hide] Tang K, Ngoi SM, Gwee PC, Chua JM, Lee EJ, Chong SS, Lee CG
Distinct haplotype profiles and strong linkage disequilibrium at the MDR1 multidrug transporter gene locus in three ethnic Asian populations.
Pharmacogenetics. 2002 Aug;12(6):437-50., [PMID:12172212]

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[hide] Yamauchi A, Ieiri I, Kataoka Y, Tanabe M, Nishizaki T, Oishi R, Higuchi S, Otsubo K, Sugimachi K
Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene.
Transplantation. 2002 Aug 27;74(4):571-2., 2002-08-27 [PMID:12352921]

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[hide] Schwab M, Eichelbaum M, Fromm MF
Genetic polymorphisms of the human MDR1 drug transporter.
Annu Rev Pharmacol Toxicol. 2003;43:285-307. Epub 2002 Jan 10., [PMID:12359865]

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[hide] Sakaeda T, Nakamura T, Okumura K
Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs.
Pharmacogenomics. 2003 Jul;4(4):397-410., [PMID:12831320]

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[hide] Kuzuya T, Kobayashi T, Moriyama N, Nagasaka T, Yokoyama I, Uchida K, Nakao A, Nabeshima T
Amlodipine, but not MDR1 polymorphisms, alters the pharmacokinetics of cyclosporine A in Japanese kidney transplant recipients.
Transplantation. 2003 Sep 15;76(5):865-8., 2003-09-15 [PMID:14501869]

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[hide] Wong M, Evans S, Rivory LP, Hoskins JM, Mann GJ, Farlow D, Clarke CL, Balleine RL, Gurney H
Hepatic technetium Tc 99m-labeled sestamibi elimination rate and ABCB1 (MDR1) genotype as indicators of ABCB1 (P-glycoprotein) activity in patients with cancer.
Clin Pharmacol Ther. 2005 Jan;77(1):33-42., [PMID:15637529]

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[hide] Nakajima M, Fujiki Y, Kyo S, Kanaya T, Nakamura M, Maida Y, Tanaka M, Inoue M, Yokoi T
Pharmacokinetics of paclitaxel in ovarian cancer patients and genetic polymorphisms of CYP2C8, CYP3A4, and MDR1.
J Clin Pharmacol. 2005 Jun;45(6):674-82., [PMID:15901749]

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[hide] Wang D, Johnson AD, Papp AC, Kroetz DL, Sadee W
Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability.
Pharmacogenet Genomics. 2005 Oct;15(10):693-704., [PMID:16141795]

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[hide] Dey S
Single nucleotide polymorphisms in human P-glycoprotein: its impact on drug delivery and disposition.
Expert Opin Drug Deliv. 2006 Jan;3(1):23-35., [PMID:16370938]

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[hide] Sakaeda T
MDR1 genotype-related pharmacokinetics: fact or fiction?
Drug Metab Pharmacokinet. 2005 Dec;20(6):391-414., [PMID:16415525]

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[hide] Rodriguez-Novoa S, Barreiro P, Jimenez-Nacher I, Soriano V
Overview of the pharmacogenetics of HIV therapy.
Pharmacogenomics J. 2006 Jul-Aug;6(4):234-45. Epub 2006 Feb 7., [PMID:16462814]

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[hide] Wong M, Balleine RL, Blair EY, McLachlan AJ, Ackland SP, Garg MB, Evans S, Farlow D, Collins M, Rivory LP, Hoskins JM, Mann GJ, Clarke CL, Gurney H
Predictors of vinorelbine pharmacokinetics and pharmacodynamics in patients with cancer.
J Clin Oncol. 2006 Jun 1;24(16):2448-55. Epub 2006 May 1., 2006-06-01 [PMID:16651648]

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[hide] Yamaguchi H, Hishinuma T, Endo N, Tsukamoto H, Kishikawa Y, Sato M, Murai Y, Hiratsuka M, Ito K, Okamura C, Yaegashi N, Suzuki N, Tomioka Y, Goto J
Genetic variation in ABCB1 influences paclitaxel pharmacokinetics in Japanese patients with ovarian cancer.
Int J Gynecol Cancer. 2006 May-Jun;16(3):979-85., [PMID:16803472]

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[hide] Ryu HC, Kwon HY, Choi IK, Rhee DK
Analyses of single nucleotide polymorphisms and haplotype linkage of the human ABCB1 (MDR1) gene in Korean.
Arch Pharm Res. 2006 Dec;29(12):1132-9., [PMID:17225463]

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[hide] Kim HJ, Hwang SY, Kim JH, Park HJ, Lee SG, Lee SW, Joo JC, Kim YK
Association between Genetic Polymorphism of Multidrug Resistance 1 Gene and Sasang Constitutions.
Evid Based Complement Alternat Med. 2009 Sep;6 Suppl 1:73-80., [PMID:19745014]

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[hide] Ni LN, Li JY, Miao KR, Qiao C, Zhang SJ, Qiu HR, Qian SX
Multidrug resistance gene (MDR1) polymorphisms correlate with imatinib response in chronic myeloid leukemia.
Med Oncol. 2011 Mar;28(1):265-9. Epub 2010 Mar 4., [PMID:20204543]

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[hide] Alpman A, Ozkinay F, Tekgul H, Gokben S, Pehlivan S, Schalling M, Ozkinay C
Multidrug resistance 1 (MDR1) gene polymorphisms in childhood drug-resistant epilepsy.
J Child Neurol. 2010 Dec;25(12):1485-90. Epub 2010 May 6., [PMID:20448249]

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[hide] Krupoves A, Mack D, Seidman E, Deslandres C, Amre D
Associations between variants in the ABCB1 (MDR1) gene and corticosteroid dependence in children with crohn's disease.
Inflamm Bowel Dis. 2011 Jan 6., 2011-01-06 [PMID:21213280]

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[hide] Milojkovic M, Stojnev S, Jovanovic I, Ljubisavljevic S, Stefanovic V, Sunder-Plassman R
Frequency of the C1236T, G2677T/A and C3435T MDR1 gene polymorphisms in the Serbian population.
Pharmacol Rep. 2011 May-Jun;63(3):808-14., [PMID:21857092]

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[hide] Krupoves A, Mack D, Seidman E, Deslandres C, Amre D
Associations between variants in the ABCB1 (MDR1) gene and corticosteroid dependence in children with Crohn's disease.
Inflamm Bowel Dis. 2011 Nov;17(11):2308-17. doi: 10.1002/ibd.21608. Epub 2011 Jan 6., [PMID:21987299]

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[hide] Sia AT, Sng BL, Lim EC, Law H, Tan EC
The influence of ATP-binding cassette sub-family B member -1 (ABCB1) genetic polymorphisms on acute and chronic pain after intrathecal morphine for caesarean section: a prospective cohort study.
Int J Obstet Anesth. 2010 Jul;19(3):254-60. Epub 2010 Jun 2., [PMID:20627697]

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[hide] Kim YO, Kim MK, Woo YJ, Lee MC, Kim JH, Park KW, Kim EY, Roh YI, Kim CJ
Single nucleotide polymorphisms in the multidrug resistance 1 gene in Korean epileptics.
Seizure. 2006 Jan;15(1):67-72., [PMID:16386926]

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[hide] Kurata Y, Ieiri I, Kimura M, Morita T, Irie S, Urae A, Ohdo S, Ohtani H, Sawada Y, Higuchi S, Otsubo K
Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein.
Clin Pharmacol Ther. 2002 Aug;72(2):209-19., [PMID:12189368]

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[hide] Ieiri I, Takane H, Otsubo K
The MDR1 (ABCB1) gene polymorphism and its clinical implications.
Clin Pharmacokinet. 2004;43(9):553-76., [PMID:15217301]

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[hide] Maleki M, Sayyah M, Kamgarpour F, Karimipoor M, Arab A, Rajabi A, Gharagozli K, Shamshiri AR, Shahsavand Ananloo E
Association between ABCB1-T1236C polymorphism and drug-resistant epilepsy in Iranian female patients.
Iran Biomed J. 2010 Jul;14(3):89-96., [PMID:21079659]

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[hide] Khabour OF, Alzoubi KH, Al-Azzam SI, Mhaidat NM
Frequency of MDR1 single nucleotide polymorphisms in a Jordanian population, including a novel variant.
Genet Mol Res. 2013 Mar 13;12(1):801-8. doi: 10.4238/2013.March.13.9., [PMID:23546964]

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[hide] Konecny GE
Are ABCB1 (P-glycoprotein) polymorphisms clinically relevant in ovarian cancer? - Finally an Answer!
Gynecol Oncol. 2013 Oct;131(1):1-2. doi: 10.1016/j.ygyno.2013.09.001., [PMID:24093937]

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[hide] Noack A, Noack S, Hoffmann A, Maalouf K, Buettner M, Couraud PO, Romero IA, Weksler B, Alms D, Romermann K, Naim HY, Loscher W
Drug-induced trafficking of p-glycoprotein in human brain capillary endothelial cells as demonstrated by exposure to mitomycin C.
PLoS One. 2014 Feb 4;9(2):e88154. doi: 10.1371/journal.pone.0088154. eCollection 2014., [PMID:24505408]

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[hide] Au A, Aziz Baba A, Goh AS, Wahid Fadilah SA, Teh A, Rosline H, Ankathil R
Association of genotypes and haplotypes of multi-drug transporter genes ABCB1 and ABCG2 with clinical response to imatinib mesylate in chronic myeloid leukemia patients.
Biomed Pharmacother. 2014 Apr;68(3):343-9. doi: 10.1016/j.biopha.2014.01.009. Epub 2014 Feb 7., [PMID:24581936]

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[hide] He H, Yin JY, Xu YJ, Li X, Zhang Y, Liu ZG, Zhou F, Zhai M, Li Y, Li XP, Wang Y, Zhou HH, Liu ZQ
Association of ABCB1 polymorphisms with the efficacy of ondansetron in chemotherapy-induced nausea and vomiting.
Clin Ther. 2014 Aug 1;36(8):1242-1252.e2. doi: 10.1016/j.clinthera.2014.06.016. Epub 2014 Jul 8., [PMID:25012726]

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