ABCB1 p.Lys578Cys

Predicted by SNAP2: A: N (93%), C: N (66%), D: N (61%), E: N (93%), F: N (66%), G: N (78%), H: N (93%), I: N (82%), L: N (82%), M: N (87%), N: N (87%), P: N (61%), Q: N (97%), R: N (97%), S: N (93%), T: N (93%), V: N (87%), W: D (66%), Y: N (61%),
Predicted by PROVEAN: A: N, C: D, D: N, E: N, F: D, G: N, H: N, I: N, L: N, M: N, N: N, P: N, Q: N, R: N, S: N, T: N, V: N, W: D, Y: N,

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[hide] Blott EJ, Higgins CF, Linton KJ
Cysteine-scanning mutagenesis provides no evidence for the extracellular accessibility of the nucleotide-binding domains of the multidrug resistance transporter P-glycoprotein.
EMBO J. 1999 Dec 1;18(23):6800-8., 1999-12-01 [PMID:10581253]

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[hide] Gabriel MP, Storm J, Rothnie A, Taylor AM, Linton KJ, Kerr ID, Callaghan R
Communication between the nucleotide binding domains of P-glycoprotein occurs via conformational changes that involve residue 508.
Biochemistry. 2003 Jul 1;42(25):7780-9., 2003-07-01 [PMID:12820887]

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