ABCB1 p.Ala58Arg

Predicted by SNAP2: C: D (53%), D: D (85%), E: D (85%), F: D (85%), G: D (63%), H: D (80%), I: D (80%), K: D (85%), L: D (85%), M: D (71%), N: D (80%), P: D (85%), Q: D (80%), R: D (85%), S: N (82%), T: D (71%), V: D (80%), W: D (91%), Y: D (85%),
Predicted by PROVEAN: C: D, D: D, E: D, F: D, G: D, H: D, I: D, K: D, L: D, M: D, N: D, P: D, Q: D, R: D, S: N, T: D, V: D, W: D, Y: D,

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[hide] Loo TW, Bartlett MC, Clarke DM
Arginines in the first transmembrane segment promote maturation of a P-glycoprotein processing mutant by hydrogen bond interactions with tyrosines in transmembrane segment 11.
J Biol Chem. 2008 Sep 5;283(36):24860-70. Epub 2008 Jul 2., 2008-09-05 [PMID:18596043]

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[hide] Taguchi Y, Morishima M, Komano T, Ueda K
Amino acid substitutions in the first transmembrane domain (TM1) of P-glycoprotein that alter substrate specificity.
FEBS Lett. 1997 Aug 11;413(1):142-6., [PMID:9287132]

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