ABCB1 p.Pro223Ala

Predicted by SNAP2: A: D (75%), C: D (80%), D: D (85%), E: D (85%), F: D (75%), G: D (80%), H: D (80%), I: D (75%), K: D (85%), L: D (80%), M: D (80%), N: D (80%), Q: D (80%), R: D (85%), S: D (75%), T: D (80%), V: D (71%), W: D (85%), Y: D (85%),
Predicted by PROVEAN: A: D, C: D, D: D, E: D, F: D, G: D, H: D, I: D, K: D, L: D, M: D, N: D, Q: D, R: D, S: D, T: D, V: D, W: D, Y: D,

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[hide] Ambudkar SV, Dey S, Hrycyna CA, Ramachandra M, Pastan I, Gottesman MM
Biochemical, cellular, and pharmacological aspects of the multidrug transporter.
Annu Rev Pharmacol Toxicol. 1999;39:361-98., [PMID:10331089]

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[hide] Loo TW, Clarke DM
Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux.
J Membr Biol. 2005 Aug;206(3):173-85., [PMID:16456713]

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[hide] Gottesman MM, Germann UA, Aksentijevich I, Sugimoto Y, Cardarelli CO, Pastan I
Gene transfer of drug resistance genes. Implications for cancer therapy.
Ann N Y Acad Sci. 1994 May 31;716:126-38; discussion 138-43., 1994-05-31 [PMID:7912913]

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[hide] Loo TW, Clarke DM
Functional consequences of phenylalanine mutations in the predicted transmembrane domain of P-glycoprotein.
J Biol Chem. 1993 Sep 25;268(27):19965-72., 1993-09-25 [PMID:8104183]

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[hide] Hanna M, Brault M, Kwan T, Kast C, Gros P
Mutagenesis of transmembrane domain 11 of P-glycoprotein by alanine scanning.
Biochemistry. 1996 Mar 19;35(11):3625-35., 1996-03-19 [PMID:8639515]

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[hide] Shilling RA, Venter H, Velamakanni S, Bapna A, Woebking B, Shahi S, van Veen HW
New light on multidrug binding by an ATP-binding-cassette transporter.
Trends Pharmacol Sci. 2006 Apr;27(4):195-203. Epub 2006 Mar 20., [PMID:16545467]

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[hide] Hrycyna CA
Molecular genetic analysis and biochemical characterization of mammalian P-glycoproteins involved in multidrug resistance.
Semin Cell Dev Biol. 2001 Jun;12(3):247-56., [PMID:11428917]

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[hide] Ueda K, Taguchi Y, Morishima M
How does P-glycoprotein recognize its substrates?
Semin Cancer Biol. 1997 Jun;8(3):151-9., [PMID:9441945]

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