ABCB1 p.Tyr401Leu

Predicted by SNAP2: A: D (85%), C: D (85%), D: D (91%), E: D (91%), F: D (80%), G: D (91%), H: D (85%), I: D (91%), K: D (95%), L: D (91%), M: D (91%), N: D (91%), P: D (95%), Q: D (91%), R: D (95%), S: D (91%), T: D (91%), V: D (85%), W: D (85%),
Predicted by PROVEAN: A: D, C: D, D: D, E: D, F: D, G: D, H: D, I: D, K: D, L: D, M: D, N: D, P: D, Q: D, R: D, S: D, T: D, V: D, W: D,

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[hide] Kim IW, Peng XH, Sauna ZE, FitzGerald PC, Xia D, Muller M, Nandigama K, Ambudkar SV
The conserved tyrosine residues 401 and 1044 in ATP sites of human P-glycoprotein are critical for ATP binding and hydrolysis: evidence for a conserved subdomain, the A-loop in the ATP-binding cassette.
Biochemistry. 2006 Jun 20;45(24):7605-16., 2006-06-20 [PMID:16768456]

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[hide] Sauna ZE, Kim IW, Ambudkar SV
Genomics and the mechanism of P-glycoprotein (ABCB1).
J Bioenerg Biomembr. 2007 Dec;39(5-6):481-7., [PMID:18058211]

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[hide] Brewer FK, Follit CA, Vogel PD, Wise JG
In silico screening for inhibitors of p-glycoprotein that target the nucleotide binding domains.
Mol Pharmacol. 2014 Dec;86(6):716-26. doi: 10.1124/mol.114.095414. Epub 2014 Sep 30., [PMID:25270578]

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