ABCB1 p.Phe951Ala

Predicted by SNAP2: A: N (57%), C: N (82%), D: D (80%), E: D (75%), G: D (53%), H: D (71%), I: N (66%), K: D (80%), L: N (72%), M: N (82%), N: D (66%), P: D (85%), Q: D (71%), R: D (80%), S: D (53%), T: D (63%), V: N (53%), W: N (53%), Y: D (63%),
Predicted by PROVEAN: A: D, C: D, D: D, E: D, G: D, H: D, I: D, K: D, L: D, M: D, N: D, P: D, Q: D, R: D, S: D, T: D, V: D, W: D, Y: N,

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[hide] Loo TW, Clarke DM
Identification of residues in the drug-binding domain of human P-glycoprotein. Analysis of transmembrane segment 11 by cysteine-scanning mutagenesis and inhibition by dibromobimane.
J Biol Chem. 1999 Dec 10;274(50):35388-92., 1999-12-10 [PMID:10585407]

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[hide] Loo TW, Bartlett MC, Clarke DM
Arginines in the first transmembrane segment promote maturation of a P-glycoprotein processing mutant by hydrogen bond interactions with tyrosines in transmembrane segment 11.
J Biol Chem. 2008 Sep 5;283(36):24860-70. Epub 2008 Jul 2., 2008-09-05 [PMID:18596043]

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