ABCB1 p.Ser400Asn

ClinVar: c.1199G>A , p.Ser400Asn N , Benign
Predicted by SNAP2: A: N (87%), C: N (57%), D: N (66%), E: N (78%), F: N (78%), G: N (87%), H: N (97%), I: N (82%), K: N (82%), L: N (72%), M: N (78%), N: N (57%), P: D (91%), Q: N (93%), R: N (97%), T: N (97%), V: N (82%), W: D (85%), Y: N (82%),
Predicted by PROVEAN: A: N, C: D, D: N, E: N, F: D, G: D, H: D, I: D, K: N, L: D, M: D, N: N, P: D, Q: N, R: D, T: N, V: D, W: D, Y: D,

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[hide] Lepper ER, Nooter K, Verweij J, Acharya MR, Figg WD, Sparreboom A
Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2.
Pharmacogenomics. 2005 Mar;6(2):115-38., [PMID:15882131] [PubMed]

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[hide] Sakurai A, Tamura A, Onishi Y, Ishikawa T
Genetic polymorphisms of ATP-binding cassette transporters ABCB1 and ABCG2: therapeutic implications.
Expert Opin Pharmacother. 2005 Nov;6(14):2455-73., [PMID:16259577] [PubMed]

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[hide] Ishikawa T, Sakurai A, Kanamori Y, Nagakura M, Hirano H, Takarada Y, Yamada K, Fukushima K, Kitajima M
High-speed screening of human ATP-binding cassette transporter function and genetic polymorphisms: new strategies in pharmacogenomics.
Methods Enzymol. 2005;400:485-510., [PMID:16399366] [PubMed]

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[hide] Cascorbi I
Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs.
Pharmacol Ther. 2006 Nov;112(2):457-73., [PMID:16766035] [PubMed]

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[hide] Sharom FJ
ABC multidrug transporters: structure, function and role in chemoresistance.
Pharmacogenomics. 2008 Jan;9(1):105-27., [PMID:18154452] [PubMed]

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[hide] Zhou SF, Di YM, Chan E, Du YM, Chow VD, Xue CC, Lai X, Wang JC, Li CG, Tian M, Duan W
Clinical pharmacogenetics and potential application in personalized medicine.
Curr Drug Metab. 2008 Oct;9(8):738-84., [PMID:18855611] [PubMed]

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[hide] Porcelli L, Lemos C, Peters GJ, Paradiso A, Azzariti A
Intracellular trafficking of MDR transporters and relevance of SNPs.
Curr Top Med Chem. 2009;9(2):197-208., [PMID:19200005] [PubMed]

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[hide] Cascorbi I, Haenisch S
Pharmacogenetics of ATP-binding cassette transporters and clinical implications.
Methods Mol Biol. 2010;596:95-121., [PMID:19949922] [PubMed]

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[hide] Kerb R, Hoffmeyer S, Brinkmann U
ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2.
Pharmacogenomics. 2001 Feb;2(1):51-64., [PMID:11258197] [PubMed]

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[hide] Colombo S, Soranzo N, Rotger M, Sprenger R, Bleiber G, Furrer H, Buclin T, Goldstein D, Decosterd L, Telenti A
Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo.
Pharmacogenet Genomics. 2005 Sep;15(9):599-608., [PMID:16041239] [PubMed]

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[hide] Bergmann TK, Brasch-Andersen C, Green H, Mirza M, Pedersen RS, Nielsen F, Skougaard K, Wihl J, Keldsen N, Damkier P, Friberg LE, Peterson C, Vach W, Karlsson MO, Brosen K
Impact of CYP2C8*3 on paclitaxel clearance: a population pharmacokinetic and pharmacogenomic study in 93 patients with ovarian cancer.
Pharmacogenomics J. 2011 Apr;11(2):113-20. Epub 2010 Apr 6., [PMID:20368717] [PubMed]

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[hide] Cascorbi I, Gerloff T, Johne A, Meisel C, Hoffmeyer S, Schwab M, Schaeffeler E, Eichelbaum M, Brinkmann U, Roots I
Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.
Clin Pharmacol Ther. 2001 Mar;69(3):169-74., [PMID:11240981] [PubMed]

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[hide] Potocnik U, Ravnik-Glavac M, Golouh R, Glavac D
Naturally occurring mutations and functional polymorphisms in multidrug resistance 1 gene: correlation with microsatellite instability and lymphoid infiltration in colorectal cancers.
J Med Genet. 2002 May;39(5):340-6., [PMID:12011154] [PubMed]

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[hide] Kimchi-Sarfaty C, Gribar JJ, Gottesman MM
Functional characterization of coding polymorphisms in the human MDR1 gene using a vaccinia virus expression system.
Mol Pharmacol. 2002 Jul;62(1):1-6., [PMID:12065748] [PubMed]

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[hide] Goto M, Masuda S, Saito H, Uemoto S, Kiuchi T, Tanaka K, Inui K
C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation.
Pharmacogenetics. 2002 Aug;12(6):451-7., [PMID:12172213] [PubMed]

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[hide] Lotsch J, Zimmermann M, Darimont J, Marx C, Dudziak R, Skarke C, Geisslinger G
Does the A118G polymorphism at the mu-opioid receptor gene protect against morphine-6-glucuronide toxicity?
Anesthesiology. 2002 Oct;97(4):814-9., [PMID:12357145] [PubMed]

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[hide] Schwab M, Eichelbaum M, Fromm MF
Genetic polymorphisms of the human MDR1 drug transporter.
Annu Rev Pharmacol Toxicol. 2003;43:285-307. Epub 2002 Jan 10., [PMID:12359865] [PubMed]

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[hide] Sakaeda T, Nakamura T, Okumura K
MDR1 genotype-related pharmacokinetics and pharmacodynamics.
Biol Pharm Bull. 2002 Nov;25(11):1391-400., [PMID:12419946] [PubMed]

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[hide] Siegmund W, Ludwig K, Giessmann T, Dazert P, Schroeder E, Sperker B, Warzok R, Kroemer HK, Cascorbi I
The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol.
Clin Pharmacol Ther. 2002 Nov;72(5):572-83., [PMID:12426521] [PubMed]

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[hide] Toffoli G, Cecchin E, Corona G, Boiocchi M
Pharmacogenetics of irinotecan.
Curr Med Chem Anticancer Agents. 2003 May;3(3):225-37., [PMID:12769780] [PubMed]

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[hide] Sakaeda T, Nakamura T, Okumura K
Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs.
Pharmacogenomics. 2003 Jul;4(4):397-410., [PMID:12831320] [PubMed]

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[hide] Kroetz DL, Pauli-Magnus C, Hodges LM, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, DeYoung J, Taylor T, Carlson EJ, Herskowitz I, Giacomini KM, Clark AG
Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene.
Pharmacogenetics. 2003 Aug;13(8):481-94., [PMID:12893986] [PubMed]

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[hide] Ambudkar SV, Kimchi-Sarfaty C, Sauna ZE, Gottesman MM
P-glycoprotein: from genomics to mechanism.
Oncogene. 2003 Oct 20;22(47):7468-85., 2003-10-20 [PMID:14576852] [PubMed]

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[hide] Sai K, Kaniwa N, Itoda M, Saito Y, Hasegawa R, Komamura K, Ueno K, Kamakura S, Kitakaze M, Shirao K, Minami H, Ohtsu A, Yoshida T, Saijo N, Kitamura Y, Kamatani N, Ozawa S, Sawada J
Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan.
Pharmacogenetics. 2003 Dec;13(12):741-57., [PMID:14646693] [PubMed]

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[hide] Wadelius M, Sorlin K, Wallerman O, Karlsson J, Yue QY, Magnusson PK, Wadelius C, Melhus H
Warfarin sensitivity related to CYP2C9, CYP3A5, ABCB1 (MDR1) and other factors.
Pharmacogenomics J. 2004;4(1):40-8., [PMID:14676821] [PubMed]

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[hide] Marzolini C, Paus E, Buclin T, Kim RB
Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance.
Clin Pharmacol Ther. 2004 Jan;75(1):13-33., [PMID:14749689] [PubMed]

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[hide] Woodahl EL, Yang Z, Bui T, Shen DD, Ho RJ
Multidrug resistance gene G1199A polymorphism alters efflux transport activity of P-glycoprotein.
J Pharmacol Exp Ther. 2004 Sep;310(3):1199-207. Epub 2004 Apr 20., [PMID:15100388] [PubMed]

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[hide] Pauli-Magnus C, Kroetz DL
Functional implications of genetic polymorphisms in the multidrug resistance gene MDR1 (ABCB1).
Pharm Res. 2004 Jun;21(6):904-13., [PMID:15212152] [PubMed]

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[hide] Ishikawa T, Onishi Y, Hirano H, Oosumi K, Nagakura M, Tarui S
Pharmacogenomics of drug transporters: a new approach to functional analysis of the genetic polymorphisms of ABCB1 (P-glycoprotein/MDR1).
Biol Pharm Bull. 2004 Jul;27(7):939-48., [PMID:15256718] [PubMed]

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[hide] Sakaeda T, Nakamura T, Okumura K
Pharmacogenetics of drug transporters and its impact on the pharmacotherapy.
Curr Top Med Chem. 2004;4(13):1385-98., [PMID:15379652] [PubMed]

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[hide] Ishikawa T, Hirano H, Onishi Y, Sakurai A, Tarui S
Functional evaluation of ABCB1 (P-glycoprotein) polymorphisms: high-speed screening and structure-activity relationship analyses.
Drug Metab Pharmacokinet. 2004 Feb;19(1):1-14., [PMID:15499164] [PubMed]

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[hide] Ozawa S, Soyama A, Saeki M, Fukushima-Uesaka H, Itoda M, Koyano S, Sai K, Ohno Y, Saito Y, Sawada J
Ethnic differences in genetic polymorphisms of CYP2D6, CYP2C19, CYP3As and MDR1/ABCB1.
Drug Metab Pharmacokinet. 2004 Apr;19(2):83-95., [PMID:15499174] [PubMed]

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[hide] Honda T, Dan Y, Koyabu N, Ieiri I, Otsubo K, Higuchi S, Ohtani H, Sawada Y
Polymorphism of MDR1 gene in healthy japanese subjects: a novel SNP with an amino acid substitution (Glu108Lys).
Drug Metab Pharmacokinet. 2002;17(5):479-81., [PMID:15618700] [PubMed]

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[hide] Itoda M, Saito Y, Komamura K, Ueno K, Kamakura S, Ozawa S, Sawada J
Twelve novel single nucleotide polymorphisms in ABCB1/MDR1 among Japanese patients with ventricular tachycardia who were administered amiodarone.
Drug Metab Pharmacokinet. 2002;17(6):566-71., [PMID:15618713] [PubMed]

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[hide] Allabi AC, Horsmans Y, Issaoui B, Gala JL
Single nucleotide polymorphisms of ABCB1 (MDR1) gene and distinct haplotype profile in a West Black African population.
Eur J Clin Pharmacol. 2005 Apr;61(2):97-102. Epub 2005 Feb 4., [PMID:15692830] [PubMed]

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[hide] Owen A, Chandler B, Back DJ
The implications of P-glycoprotein in HIV: friend or foe?
Fundam Clin Pharmacol. 2005 Jun;19(3):283-96., [PMID:15910652] [PubMed]

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[hide] Hung CC, Tai JJ, Lin CJ, Lee MJ, Liou HH
Complex haplotypic effects of the ABCB1 gene on epilepsy treatment response.
Pharmacogenomics. 2005 Jun;6(4):411-7., [PMID:16004559] [PubMed]

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[hide] Woodahl EL, Yang Z, Bui T, Shen DD, Ho RJ
MDR1 G1199A polymorphism alters permeability of HIV protease inhibitors across P-glycoprotein-expressing epithelial cells.
AIDS. 2005 Oct 14;19(15):1617-25., 2005-10-14 [PMID:16184031] [PubMed]

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[hide] Dey S
Single nucleotide polymorphisms in human P-glycoprotein: its impact on drug delivery and disposition.
Expert Opin Drug Deliv. 2006 Jan;3(1):23-35., [PMID:16370938] [PubMed]

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[hide] Sakaeda T
MDR1 genotype-related pharmacokinetics: fact or fiction?
Drug Metab Pharmacokinet. 2005 Dec;20(6):391-414., [PMID:16415525] [PubMed]

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[hide] Leschziner G, Zabaneh D, Pirmohamed M, Owen A, Rogers J, Coffey AJ, Balding DJ, Bentley DB, Johnson MR
Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance.
Pharmacogenet Genomics. 2006 Jun;16(6):439-50., [PMID:16708052] [PubMed]

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[hide] Owen A, Pirmohamed M, Khoo SH, Back DJ
Pharmacogenetics of HIV therapy.
Pharmacogenet Genomics. 2006 Oct;16(10):693-703., [PMID:17001288] [PubMed]

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[hide] Nordgard SH, Ritchie MD, Jensrud SD, Motsinger AA, Alnaes GI, Lemmon G, Berg M, Geisler S, Moore JH, Lonning PE, Borresen-Dale AL, Kristensen VN
ABCB1 and GST polymorphisms associated with TP53 status in breast cancer.
Pharmacogenet Genomics. 2007 Feb;17(2):127-36., [PMID:17301692] [PubMed]

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[hide] Zhang WX, Chen B, Zhang W, Chen N, Yu ZC, Cai WM
Effect of MDR1 gene polymorphism on progression of end-stage renal disease.
Acta Pharmacol Sin. 2007 Apr;28(4):579-83., [PMID:17376299] [PubMed]

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[hide] Sakurai A, Onishi Y, Hirano H, Seigneuret M, Obanayama K, Kim G, Liew EL, Sakaeda T, Yoshiura K, Niikawa N, Sakurai M, Ishikawa T
Quantitative structure--activity relationship analysis and molecular dynamics simulation to functionally validate nonsynonymous polymorphisms of human ABC transporter ABCB1 (P-glycoprotein/MDR1).
Biochemistry. 2007 Jul 3;46(26):7678-93. Epub 2007 Jun 9., 2007-07-03 [PMID:17559192] [PubMed]

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[hide] Woodahl EL, Hingorani SR, Wang J, Guthrie KA, McDonald GB, Batchelder A, Li M, Schoch HG, McCune JS
Pharmacogenomic associations in ABCB1 and CYP3A5 with acute kidney injury and chronic kidney disease after myeloablative hematopoietic cell transplantation.
Pharmacogenomics J. 2008 Aug;8(4):248-55. Epub 2007 Aug 14., [PMID:17700595] [PubMed]

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[hide] Seedhouse CH, Grundy M, White P, Li Y, Fisher J, Yakunina D, Moorman AV, Hoy T, Russell N, Burnett A, Pallis M
Sequential influences of leukemia-specific and genetic factors on p-glycoprotein expression in blasts from 817 patients entered into the National Cancer Research Network acute myeloid leukemia 14 and 15 trials.
Clin Cancer Res. 2007 Dec 1;13(23):7059-66., 2007-12-01 [PMID:18056183] [PubMed]

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[hide] Gow JM, Hodges LM, Chinn LW, Kroetz DL
Substrate-dependent effects of human ABCB1 coding polymorphisms.
J Pharmacol Exp Ther. 2008 May;325(2):435-42. Epub 2008 Feb 20., [PMID:18287207] [PubMed]

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[hide] Vaclavikova R, Nordgard SH, Alnaes GI, Hubackova M, Kubala E, Kodet R, Mrhalova M, Novotny J, Gut I, Kristensen VN, Soucek P
Single nucleotide polymorphisms in the multidrug resistance gene 1 (ABCB1): effects on its expression and clinicopathological characteristics in breast cancer patients.
Pharmacogenet Genomics. 2008 Mar;18(3):263-73., [PMID:18300948] [PubMed]

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[hide] Crettol S, Venetz JP, Fontana M, Aubert JD, Ansermot N, Fathi M, Pascual M, Eap CB
Influence of ABCB1 genetic polymorphisms on cyclosporine intracellular concentration in transplant recipients.
Pharmacogenet Genomics. 2008 Apr;18(4):307-15., [PMID:18334915] [PubMed]

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[hide] Zhou SF
Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition.
Xenobiotica. 2008 Jul;38(7-8):802-32., [PMID:18668431] [PubMed]

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[hide] Woodahl EL, Crouthamel MH, Bui T, Shen DD, Ho RJ
MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents.
Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8. Epub 2009 Jan 4., [PMID:19123050] [PubMed]

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[hide] Tripodi G, Citterio L, Kouznetsova T, Lanzani C, Florio M, Modica R, Messaggio E, Hamlyn JM, Zagato L, Bianchi G, Staessen JA, Manunta P
Steroid biosynthesis and renal excretion in human essential hypertension: association with blood pressure and endogenous ouabain.
Am J Hypertens. 2009 Apr;22(4):357-63. Epub 2009 Feb 5., [PMID:19197249] [PubMed]

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[hide] Hamidovic A, Hahn K, Kolesar J
Clinical significance of ABCB1 genotyping in oncology.
J Oncol Pharm Pract. 2010 Mar;16(1):39-44. Epub 2009 Apr 28., [PMID:19401306] [PubMed]

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[hide] Keskitalo JE, Kurkinen KJ, Neuvonen M, Backman JT, Neuvonen PJ, Niemi M
No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin.
Br J Clin Pharmacol. 2009 Aug;68(2):207-13., [PMID:19694740] [PubMed]

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[hide] Mukonzo JK, Roshammar D, Waako P, Andersson M, Fukasawa T, Milani L, Svensson JO, Ogwal-Okeng J, Gustafsson LL, Aklillu E
A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans.
Br J Clin Pharmacol. 2009 Nov;68(5):690-9., [PMID:19916993] [PubMed]

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[hide] Eyal S, Ke B, Muzi M, Link JM, Mankoff DA, Collier AC, Unadkat JD
Regional P-glycoprotein activity and inhibition at the human blood-brain barrier as imaged by positron emission tomography.
Clin Pharmacol Ther. 2010 May;87(5):579-85. Epub 2010 Mar 24., [PMID:20336065] [PubMed]

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[hide] Mukonzo JK, Waako P, Ogwal-Okeng J, Gustafsson LL, Aklillu E
Genetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among Ugandans.
Ther Drug Monit. 2010 Jun;32(3):346-52., [PMID:20357698] [PubMed]

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[hide] Tapaninen T, Neuvonen PJ, Niemi M
Effect of ABCB1 haplotypes on the pharmacokinetics and renin-inhibiting effect of aliskiren.
Eur J Clin Pharmacol. 2010 Sep;66(9):865-70. Epub 2010 May 23., [PMID:20496145] [PubMed]

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[hide] Cascorbi I
P-glycoprotein: tissue distribution, substrates, and functional consequences of genetic variations.
Handb Exp Pharmacol. 2011;(201):261-83., [PMID:21103972] [PubMed]

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[hide] Rudolph A, Sainz J, Hein R, Hoffmeister M, Frank B, Forsti A, Brenner H, Hemminki K, Chang-Claude J
Modification of menopausal hormone therapy-associated colorectal cancer risk by polymorphisms in sex steroid signaling, metabolism and transport related genes.
Endocr Relat Cancer. 2011 Jun 8;18(3):371-84. Print 2011., [PMID:21490239] [PubMed]

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[hide] Wolf SJ, Bachtiar M, Wang J, Sim TS, Chong SS, Lee CG
An update on ABCB1 pharmacogenetics: insights from a 3D model into the location and evolutionary conservation of residues corresponding to SNPs associated with drug pharmacokinetics.
Pharmacogenomics J. 2011 Oct;11(5):315-25. doi: 10.1038/tpj.2011.16. Epub 2011 May 31., [PMID:21625253] [PubMed]

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[hide] Klaassen CD, Aleksunes LM
Xenobiotic, bile acid, and cholesterol transporters: function and regulation.
Pharmacol Rev. 2010 Mar;62(1):1-96. Epub 2010 Jan 26., [PMID:20103563] [PubMed]

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[hide] Grover S, Gourie-Devi M, Bala K, Sharma S, Kukreti R
Genetic association analysis of transporters identifies ABCC2 loci for seizure control in women with epilepsy on first-line antiepileptic drugs.
Pharmacogenet Genomics. 2012 Jun;22(6):447-65., [PMID:22565165] [PubMed]

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[hide] De Meyer M, Haufroid V, Elens L, Fusaro F, Patrono D, De Pauw L, Kanaan N, Goffin E, Mourad M
Donor age and ABCB1 1199G>A genetic polymorphism are independent factors affecting long-term renal function after kidney transplantation.
J Surg Res. 2012 Dec;178(2):988-95. doi: 10.1016/j.jss.2012.06.070. Epub 2012 Jul 20., [PMID:22835948] [PubMed]

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[hide] Ishikawa T, Sakurai A, Hirano H, Lezhava A, Sakurai M, Hayashizaki Y
Emerging new technologies in Pharmacogenomics: rapid SNP detection, molecular dynamic simulation, and QSAR analysis methods to validate clinically important genetic variants of human ABC Transporter ABCB1 (P-gp/MDR1).
Pharmacol Ther. 2010 Apr;126(1):69-81. Epub 2010 Feb 4., [PMID:20138191] [PubMed]

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[hide] Benish RL, Rodriguez B, Zimmerman PA, Mehlotra RK
Comparative description of haplotype structure and genetic diversity of MDR1 (ABCB1) in HIV-positive and HIV-negative populations.
Infect Genet Evol. 2010 Jan;10(1):60-7. Epub 2009 Oct 9., [PMID:19819348] [PubMed]

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[hide] Fung KL, Gottesman MM
A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function.
Biochim Biophys Acta. 2009 May;1794(5):860-71. Epub 2009 Mar 11., [PMID:19285158] [PubMed]

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[hide] Kerb R
Implications of genetic polymorphisms in drug transporters for pharmacotherapy.
Cancer Lett. 2006 Mar 8;234(1):4-33. Epub 2006 Feb 28., [PMID:16504381] [PubMed]

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[hide] Li YH, Wang YH, Li Y, Yang L
MDR1 gene polymorphisms and clinical relevance.
Yi Chuan Xue Bao. 2006 Feb;33(2):93-104., [PMID:16529292] [PubMed]

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[hide] Fromm MF
The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans.
Adv Drug Deliv Rev. 2002 Nov 18;54(10):1295-310., [PMID:12406646] [PubMed]

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[hide] Siegmund W, Altmannsberger S, Paneitz A, Hecker U, Zschiesche M, Franke G, Meng W, Warzok R, Schroeder E, Sperker B, Terhaag B, Cascorbi I, Kroemer HK
Effect of levothyroxine administration on intestinal P-glycoprotein expression: consequences for drug disposition.
Clin Pharmacol Ther. 2002 Sep;72(3):256-64., [PMID:12235446] [PubMed]

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[hide] Brinkmann U, Roots I, Eichelbaum M
Pharmacogenetics of the human drug-transporter gene MDR1: impact of polymorphisms on pharmacotherapy.
Drug Discov Today. 2001 Aug 15;6(16):835-839., [PMID:11495756] [PubMed]

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[hide] Lambrechts S, Lambrechts D, Despierre E, Van Nieuwenhuysen E, Smeets D, Debruyne PR, Renard V, Vroman P, Luyten D, Neven P, Amant F, Leunen K, Vergote I
Genetic variability in drug transport, metabolism or DNA repair affecting toxicity of chemotherapy in ovarian cancer.
BMC Pharmacol Toxicol. 2015 Feb 27;16:2. doi: 10.1186/s40360-015-0001-5., [PMID:25881102] [PubMed]

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[hide] Ieiri I, Takane H, Otsubo K
The MDR1 (ABCB1) gene polymorphism and its clinical implications.
Clin Pharmacokinet. 2004;43(9):553-76., [PMID:15217301] [PubMed]

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[hide] Bosch TM, Meijerman I, Beijnen JH, Schellens JH
Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer.
Clin Pharmacokinet. 2006;45(3):253-85., [PMID:16509759] [PubMed]

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[hide] Dessilly G, Elens L, Panin N, Capron A, Decottignies A, Demoulin JB, Haufroid V
ABCB1 1199G>A genetic polymorphism (Rs2229109) influences the intracellular accumulation of tacrolimus in HEK293 and K562 recombinant cell lines.
PLoS One. 2014 Mar 12;9(3):e91555. doi: 10.1371/journal.pone.0091555. eCollection 2014., [PMID:24621983] [PubMed]

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[hide] Jordheim LP, Ribrag V, Ghesquieres H, Pallardy S, Delarue R, Tilly H, Haioun C, Jardin F, Demangel D, Salles GA, Dumontet C
Single nucleotide polymorphisms in ABCB1 and CBR1 can predict toxicity to R-CHOP type regimens in patients with diffuse non-Hodgkin lymphoma.
Haematologica. 2015 May;100(5):e204-6. doi: 10.3324/haematol.2014.120113. Epub 2015 Jan 30., [PMID:25637052] [PubMed]

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[hide] Wolking S, Schaeffeler E, Lerche H, Schwab M, Nies AT
Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature.
Clin Pharmacokinet. 2015 Jul;54(7):709-35. doi: 10.1007/s40262-015-0267-1., [PMID:25860377] [PubMed]

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