ABCB1 p.Leu322Pro
| Predicted by SNAP2: | A: N (66%), C: D (53%), D: D (75%), E: D (75%), F: N (78%), G: D (66%), H: D (53%), I: N (93%), K: D (75%), M: N (93%), N: D (66%), P: D (75%), Q: N (66%), R: N (72%), S: D (59%), T: D (59%), V: N (87%), W: D (71%), Y: D (63%), |
| Predicted by PROVEAN: | A: D, C: D, D: D, E: D, F: D, G: D, H: D, I: N, K: D, M: N, N: D, P: D, Q: D, R: D, S: D, T: D, V: N, W: D, Y: D, |
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[hide] DeltaNp73alpha regulates MDR1 expression by inhibi... Oncogene. 2008 Apr 3;27(15):2170-6. Epub 2007 Oct 22. Vilgelm A, Wei JX, Piazuelo MB, Washington MK, Prassolov V, El-Rifai W, Zaika A
DeltaNp73alpha regulates MDR1 expression by inhibiting p53 function.
Oncogene. 2008 Apr 3;27(15):2170-6. Epub 2007 Oct 22., 2008-04-03 [PMID:17952118]
Abstract [show]
The p73 protein is a transcription factor and member of the p53 protein family that expresses as a complex variety of isoforms. DeltaNp73alpha is an N-terminally truncated isoform of p73. We found that DeltaNp73 protein is upregulated in human gastric carcinoma suggesting that DeltaNp73 may play an oncogenic role in these tumors. Although it has been shown that DeltaNp73alpha inhibits apoptosis and counteracts the effect of chemotherapeutic drugs, the underlying mechanism by which this p73 isoform contributes to chemotherapeutic drug response remains to be explored. We found that DeltaNp73alpha upregulates MDR1 mRNA and p-glycoprotein (p-gp), which is involved in chemotherapeutic drug transport. This p-gp upregulation was accompanied by increased p-gp functional activity in gastric cancer cells. Our data suggest that upregulation of MDR1 by DeltaNp73alpha is mediated by interaction with p53 at the MDR1 promoter.
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No. Sentence Comment
38 Interestingly, mutant DNp73a (L322P) was unable to increase the MDR1 mRNA level.
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ABCB1 p.Leu322Pro 17952118:38:30
status: NEW121 Interestingly, DNp73a(L322P) mutant, which has an impaired ability to inhibit p53, was unable to activate mdr1 gene transcription (Zaika et al., 2002).
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ABCB1 p.Leu322Pro 17952118:121:22
status: NEW