ABCB1 p.Gly894Thr
| Predicted by SNAP2: | A: D (63%), C: D (75%), D: D (91%), E: D (91%), F: D (91%), H: D (91%), I: D (85%), K: D (95%), L: D (91%), M: D (91%), N: D (85%), P: D (91%), Q: D (91%), R: D (95%), S: D (75%), T: D (80%), V: D (85%), W: D (91%), Y: D (91%), |
| Predicted by PROVEAN: | A: D, C: D, D: D, E: D, F: D, H: D, I: D, K: D, L: D, M: D, N: D, P: D, Q: D, R: D, S: D, T: D, V: D, W: D, Y: D, |
[switch to compact view]
Comments [show]
None has been submitted yet.
[hide] Molecular basis of ethnic differences in drug disp... Annu Rev Pharmacol Toxicol. 2001;41:815-50. Xie HG, Kim RB, Wood AJ, Stein CM
Molecular basis of ethnic differences in drug disposition and response.
Annu Rev Pharmacol Toxicol. 2001;41:815-50., [PMID:11264478]
Abstract [show]
Ethnicity is an important demographic variable contributing to interindividual variability in drug metabolism and response. In this rapidly expanding research area many genetic factors that account for the effects of ethnicity on pharmacokinetics, pharmacodynamics, and drug safety have been identified. This review focuses on recent developments that have improved understanding of the molecular mechanisms responsible for such interethnic differences. Genetic variations that may provide a molecular basis for ethnic differences in drug metabolizing enzymes (CYP 2C9, 2C19, 2D6, and 3A4), drug transporter (P-glycoprotein), drug receptors (adrenoceptors), and other functionally important proteins (eNOS and G proteins) are discussed. A better understanding of the molecular basis underlying ethnic differences in drug metabolism, transport, and response will contribute to improved individualization of drug therapy.
Comments [show]
None has been submitted yet.
No. Sentence Comment
1122 G894T polymorphism in the endothelial nitric oxide synthase gene is associated with an enhanced vascular responsiveness to phenylephrine.
X
ABCB1 p.Gly894Thr 11264478:1122:0
status: NEW