ABCB1 p.Ala80Arg

Predicted by SNAP2: C: N (53%), D: D (71%), E: D (71%), F: D (59%), G: N (61%), H: D (66%), I: N (93%), K: D (66%), L: N (82%), M: D (59%), N: N (61%), P: D (75%), Q: N (57%), R: N (53%), S: N (87%), T: N (93%), V: N (97%), W: D (63%), Y: D (71%),
Predicted by PROVEAN: C: N, D: N, E: N, F: N, G: N, H: N, I: N, K: N, L: N, M: N, N: N, P: N, Q: N, R: N, S: N, T: N, V: N, W: D, Y: N,

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[hide] Loo TW, Clarke DM
Cysteines introduced into extracellular loops 1 and 4 of human P-glycoprotein that are close only in the open conformation spontaneously form a disulfide bond that inhibits drug efflux and ATPase activity.
J Biol Chem. 2014 Sep 5;289(36):24749-58. doi: 10.1074/jbc.M114.583021. Epub 2014 Jul 22., [PMID:25053414]

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