ABCB1 p.Asp555Asn

Predicted by SNAP2: A: D (91%), C: D (85%), E: D (85%), F: D (91%), G: D (91%), H: D (91%), I: D (91%), K: D (91%), L: D (91%), M: D (91%), N: D (91%), P: D (95%), Q: D (91%), R: D (91%), S: D (85%), T: D (85%), V: D (91%), W: D (95%), Y: D (91%),
Predicted by PROVEAN: A: D, C: D, E: D, F: D, G: D, H: D, I: D, K: D, L: D, M: D, N: D, P: D, Q: D, R: D, S: D, T: D, V: D, W: D, Y: D,

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Publications
[hide] Frelet A, Klein M
Insight in eukaryotic ABC transporter function by mutation analysis.
FEBS Lett. 2006 Feb 13;580(4):1064-84. Epub 2006 Jan 19., 2006-02-13 [PMID:16442101] [PubMed]

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[hide] Hrycyna CA, Ramachandra M, Germann UA, Cheng PW, Pastan I, Gottesman MM
Both ATP sites of human P-glycoprotein are essential but not symmetric.
Biochemistry. 1999 Oct 19;38(42):13887-99., 1999-10-19 [PMID:10529234] [PubMed]

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[hide] Lee CG, Ramachandra M, Jeang KT, Martin MA, Pastan I, Gottesman MM
Effect of ABC transporters on HIV-1 infection: inhibition of virus production by the MDR1 transporter.
FASEB J. 2000 Mar;14(3):516-22., [PMID:10698967] [PubMed]

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[hide] Julien M, Gros P
Nucleotide-induced conformational changes in P-glycoprotein and in nucleotide binding site mutants monitored by trypsin sensitivity.
Biochemistry. 2000 Apr 18;39(15):4559-68., 2000-04-18 [PMID:10758006] [PubMed]

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[hide] Booth CL, Pulaski L, Gottesman MM, Pastan I
Analysis of the properties of the N-terminal nucleotide-binding domain of human P-glycoprotein.
Biochemistry. 2000 May 9;39(18):5518-26., 2000-05-09 [PMID:10820025] [PubMed]

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[hide] Sauna ZE, Smith MM, Muller M, Ambudkar SV
Functionally similar vanadate-induced 8-azidoadenosine 5'-[alpha-(32)P]Diphosphate-trapped transition state intermediates of human P-glycoprotin are generated in the absence and presence of ATP hydrolysis.
J Biol Chem. 2001 Jun 15;276(24):21199-208. Epub 2001 Apr 3., 2001-06-15 [PMID:11287418] [PubMed]

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[hide] Russ G, Ramachandra M, Hrycyna CA, Gottesman MM, Pastan I, Bennink JR, Yewdell JW
P-glycoprotein plays an insignificant role in the presentation of antigenic peptides to CD8+ T cells.
Cancer Res. 1998 Oct 15;58(20):4688-93., [PMID:9788623] [PubMed]

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[hide] Shilling RA, Venter H, Velamakanni S, Bapna A, Woebking B, Shahi S, van Veen HW
New light on multidrug binding by an ATP-binding-cassette transporter.
Trends Pharmacol Sci. 2006 Apr;27(4):195-203. Epub 2006 Mar 20., [PMID:16545467] [PubMed]

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