ABCB1 p.Phe72Arg

Predicted by SNAP2: A: D (59%), C: N (61%), D: D (85%), E: D (75%), G: D (75%), H: D (75%), I: D (53%), K: D (85%), L: N (66%), M: N (61%), N: D (80%), P: D (85%), Q: D (63%), R: D (80%), S: D (66%), T: D (66%), V: D (59%), W: D (66%), Y: N (78%),
Predicted by PROVEAN: A: D, C: D, D: D, E: D, G: D, H: D, I: D, K: D, L: D, M: D, N: D, P: D, Q: D, R: D, S: D, T: D, V: D, W: D, Y: N,

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[hide] Loo TW, Bartlett MC, Clarke DM
Arginines in the first transmembrane segment promote maturation of a P-glycoprotein processing mutant by hydrogen bond interactions with tyrosines in transmembrane segment 11.
J Biol Chem. 2008 Sep 5;283(36):24860-70. Epub 2008 Jul 2., 2008-09-05 [PMID:18596043]

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[hide] Loo TW, Clarke DM
Mapping the Binding Site of the Inhibitor Tariquidar That Stabilizes the First Transmembrane Domain of P-glycoprotein.
J Biol Chem. 2015 Dec 4;290(49):29389-401. doi: 10.1074/jbc.M115.695171. Epub 2015 Oct 26., [PMID:26507655]

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