ABCB1 p.Tyr953Ala

Predicted by SNAP2: A: D (66%), C: D (59%), D: D (75%), E: D (75%), F: N (53%), G: D (71%), H: D (53%), I: N (53%), K: D (85%), L: D (59%), M: D (71%), N: N (57%), P: D (91%), Q: D (71%), R: D (85%), S: D (59%), T: D (66%), V: D (53%), W: D (71%),
Predicted by PROVEAN: A: D, C: D, D: D, E: D, F: D, G: D, H: D, I: D, K: D, L: D, M: D, N: D, P: D, Q: D, R: D, S: D, T: D, V: D, W: D,

[switch to compact view]
Comments [show]
Publications
[hide] Loo TW, Clarke DM
Identification of residues in the drug-binding domain of human P-glycoprotein. Analysis of transmembrane segment 11 by cysteine-scanning mutagenesis and inhibition by dibromobimane.
J Biol Chem. 1999 Dec 10;274(50):35388-92., 1999-12-10 [PMID:10585407]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Loo TW, Bartlett MC, Clarke DM
Arginines in the first transmembrane segment promote maturation of a P-glycoprotein processing mutant by hydrogen bond interactions with tyrosines in transmembrane segment 11.
J Biol Chem. 2008 Sep 5;283(36):24860-70. Epub 2008 Jul 2., 2008-09-05 [PMID:18596043]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Donmez Cakil Y, Khunweeraphong N, Parveen Z, Schmid D, Artaker M, Ecker GF, Sitte HH, Pusch O, Stockner T, Chiba P
Pore-exposed tyrosine residues of P-glycoprotein are important hydrogen-bonding partners for drugs.
Mol Pharmacol. 2014 Mar;85(3):420-8. doi: 10.1124/mol.113.088526. Epub 2013 Dec 23., [PMID:24366667]

Abstract [show]
Comments [show]
Sentences [show]