ABCB1 p.Phe978Cys

Predicted by SNAP2: A: D (66%), C: N (57%), D: D (91%), E: D (85%), G: D (80%), H: D (80%), I: N (78%), K: D (85%), L: N (66%), M: N (53%), N: D (75%), P: D (91%), Q: D (71%), R: D (85%), S: N (53%), T: D (71%), V: N (61%), W: D (85%), Y: D (66%),
Predicted by PROVEAN: A: D, C: D, D: D, E: D, G: D, H: D, I: D, K: D, L: D, M: D, N: D, P: D, Q: D, R: D, S: D, T: D, V: D, W: D, Y: N,

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[hide] Crowley E, O'Mara ML, Reynolds C, Tieleman DP, Storm J, Kerr ID, Callaghan R
Transmembrane helix 12 modulates progression of the ATP catalytic cycle in ABCB1.
Biochemistry. 2009 Jul 7;48(26):6249-58., 2009-07-07 [PMID:19456124] [PubMed]

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[hide] Loo TW, Clarke DM
Inhibition of oxidative cross-linking between engineered cysteine residues at positions 332 in predicted transmembrane segments (TM) 6 and 975 in predicted TM12 of human P-glycoprotein by drug substrates.
J Biol Chem. 1996 Nov 1;271(44):27482-7., 1996-11-01 [PMID:8910331] [PubMed]

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[hide] Loo TW, Clarke DM
Identification of residues in the drug-binding site of human P-glycoprotein using a thiol-reactive substrate.
J Biol Chem. 1997 Dec 19;272(51):31945-8., 1997-12-19 [PMID:9405384] [PubMed]

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[hide] Chufan EE, Kapoor K, Sim HM, Singh S, Talele TT, Durell SR, Ambudkar SV
Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1).
PLoS One. 2013 Dec 5;8(12):e82463. doi: 10.1371/journal.pone.0082463. eCollection 2013., [PMID:24349290] [PubMed]

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