ABCB1 p.Ala63Arg

Predicted by SNAP2: C: N (97%), D: D (66%), E: D (63%), F: N (57%), G: N (61%), H: D (53%), I: N (93%), K: D (63%), L: N (93%), M: N (97%), N: D (53%), P: D (66%), Q: N (61%), R: D (59%), S: N (93%), T: N (93%), V: N (97%), W: D (71%), Y: D (63%),
Predicted by PROVEAN: C: N, D: D, E: N, F: D, G: N, H: D, I: N, K: N, L: N, M: N, N: D, P: D, Q: N, R: D, S: N, T: N, V: N, W: D, Y: D,

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[hide] Loo TW, Bartlett MC, Clarke DM
Arginines in the first transmembrane segment promote maturation of a P-glycoprotein processing mutant by hydrogen bond interactions with tyrosines in transmembrane segment 11.
J Biol Chem. 2008 Sep 5;283(36):24860-70. Epub 2008 Jul 2., 2008-09-05 [PMID:18596043]

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[hide] Taguchi Y, Morishima M, Komano T, Ueda K
Amino acid substitutions in the first transmembrane domain (TM1) of P-glycoprotein that alter substrate specificity.
FEBS Lett. 1997 Aug 11;413(1):142-6., [PMID:9287132]

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