ABCB1 p.Thr199Cys

Predicted by SNAP2: A: D (59%), C: D (66%), D: D (80%), E: D (85%), F: D (85%), G: D (53%), H: D (71%), I: D (63%), K: D (91%), L: D (66%), M: N (66%), N: D (75%), P: D (91%), Q: D (66%), R: D (71%), S: N (72%), V: D (80%), W: D (85%), Y: D (75%),
Predicted by PROVEAN: A: D, C: D, D: D, E: D, F: D, G: D, H: D, I: D, K: D, L: D, M: D, N: D, P: D, Q: D, R: D, S: N, V: D, W: D, Y: D,

[switch to compact view]
Comments [show]
Publications
[hide] Loo TW, Bartlett MC, Clarke DM
Suppressor mutations in the transmembrane segments of P-glycoprotein promote maturation of processing mutants and disrupt a subset of drug-binding sites.
J Biol Chem. 2007 Nov 2;282(44):32043-52. Epub 2007 Sep 11., 2007-11-02 [PMID:17848563]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Loo TW, Bartlett MC, Detty MR, Clarke DM
The ATPase activity of the P-glycoprotein drug pump is highly activated when the N-terminal and central regions of the nucleotide-binding domains are linked closely together.
J Biol Chem. 2012 Aug 3;287(32):26806-16. doi: 10.1074/jbc.M112.376202. Epub 2012 Jun 14., [PMID:22700974]

Abstract [show]
Comments [show]
Sentences [show]