ABCG2 p.Arg482Gly

Predicted by SNAP2: A: D (91%), C: D (85%), D: D (95%), E: D (95%), F: D (91%), G: D (95%), H: D (95%), I: D (85%), K: D (85%), L: D (91%), M: D (85%), N: D (95%), P: D (95%), Q: D (95%), S: D (91%), T: D (91%), V: D (91%), W: D (95%), Y: D (95%),
Predicted by PROVEAN: A: D, C: D, D: D, E: D, F: D, G: D, H: D, I: D, K: D, L: D, M: D, N: D, P: D, Q: D, S: D, T: D, V: D, W: D, Y: D,

[switch to compact view]
Comments [show]
Publications
[hide] Honjo Y, Hrycyna CA, Yan QW, Medina-Perez WY, Robey RW, van de Laar A, Litman T, Dean M, Bates SE
Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.
Cancer Res. 2001 Sep 15;61(18):6635-9., 2001-09-15 [PMID:11559526]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Bates SE, Robey R, Miyake K, Rao K, Ross DD, Litman T
The role of half-transporters in multidrug resistance.
J Bioenerg Biomembr. 2001 Dec;33(6):503-11., [PMID:11804192]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Allen JD, Jackson SC, Schinkel AH
A mutation hot spot in the Bcrp1 (Abcg2) multidrug transporter in mouse cell lines selected for Doxorubicin resistance.
Cancer Res. 2002 Apr 15;62(8):2294-9., 2002-04-15 [PMID:11956086]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Volk EL, Farley KM, Wu Y, Li F, Robey RW, Schneider E
Overexpression of wild-type breast cancer resistance protein mediates methotrexate resistance.
Cancer Res. 2002 Sep 1;62(17):5035-40., 2002-09-01 [PMID:12208758]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Ozvegy C, Varadi A, Sarkadi B
Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter. Modulation of substrate specificity by a point mutation.
J Biol Chem. 2002 Dec 13;277(50):47980-90. Epub 2002 Oct 8., 2002-12-13 [PMID:12374800]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Wang X, Furukawa T, Nitanda T, Okamoto M, Sugimoto Y, Akiyama S, Baba M
Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors.
Mol Pharmacol. 2003 Jan;63(1):65-72., [PMID:12488537]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Schinkel AH, Jonker JW
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview.
Adv Drug Deliv Rev. 2003 Jan 21;55(1):3-29., 2003-01-21 [PMID:12535572]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Zamber CP, Lamba JK, Yasuda K, Farnum J, Thummel K, Schuetz JD, Schuetz EG
Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine.
Pharmacogenetics. 2003 Jan;13(1):19-28., [PMID:12544509]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Ujhelly O, Ozvegy C, Varady G, Cervenak J, Homolya L, Grez M, Scheffer G, Roos D, Bates SE, Varadi A, Sarkadi B, Nemet K
Application of a human multidrug transporter (ABCG2) variant as selectable marker in gene transfer to progenitor cells.
Hum Gene Ther. 2003 Mar 1;14(4):403-12., 2003-03-01 [PMID:12659681]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Chen ZS, Robey RW, Belinsky MG, Shchaveleva I, Ren XQ, Sugimoto Y, Ross DD, Bates SE, Kruh GD
Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport.
Cancer Res. 2003 Jul 15;63(14):4048-54., 2003-07-15 [PMID:12874005]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Nakanishi T, Karp JE, Tan M, Doyle LA, Peters T, Yang W, Wei D, Ross DD
Quantitative analysis of breast cancer resistance protein and cellular resistance to flavopiridol in acute leukemia patients.
Clin Cancer Res. 2003 Aug 15;9(9):3320-8., 2003-08-15 [PMID:12960118]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Volk EL, Schneider E
Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter.
Cancer Res. 2003 Sep 1;63(17):5538-43., 2003-09-01 [PMID:14500392]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Miwa M, Tsukahara S, Ishikawa E, Asada S, Imai Y, Sugimoto Y
Single amino acid substitutions in the transmembrane domains of breast cancer resistance protein (BCRP) alter cross resistance patterns in transfectants.
Int J Cancer. 2003 Dec 10;107(5):757-63., 2003-12-10 [PMID:14566825]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Doyle LA, Ross DD
Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2).
Oncogene. 2003 Oct 20;22(47):7340-58., 2003-10-20 [PMID:14576842]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Robey RW, Honjo Y, Morisaki K, Nadjem TA, Runge S, Risbood M, Poruchynsky MS, Bates SE
Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity.
Br J Cancer. 2003 Nov 17;89(10):1971-8., 2003-11-17 [PMID:14612912]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Dietrich CG, Geier A, Oude Elferink RP
ABC of oral bioavailability: transporters as gatekeepers in the gut.
Gut. 2003 Dec;52(12):1788-95., [PMID:14633964]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Nakanishi T, Doyle LA, Hassel B, Wei Y, Bauer KS, Wu S, Pumplin DW, Fang HB, Ross DD
Functional characterization of human breast cancer resistance protein (BCRP, ABCG2) expressed in the oocytes of Xenopus laevis.
Mol Pharmacol. 2003 Dec;64(6):1452-62., [PMID:14645676]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Mizuarai S, Aozasa N, Kotani H
Single nucleotide polymorphisms result in impaired membrane localization and reduced atpase activity in multidrug transporter ABCG2.
Int J Cancer. 2004 Mar 20;109(2):238-46., 2004-03-20 [PMID:14750175]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Han B, Zhang JT
Multidrug resistance in cancer chemotherapy and xenobiotic protection mediated by the half ATP-binding cassette transporter ABCG2.
Curr Med Chem Anticancer Agents. 2004 Jan;4(1):31-42., [PMID:14754410]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Robey RW, Steadman K, Polgar O, Morisaki K, Blayney M, Mistry P, Bates SE
Pheophorbide a is a specific probe for ABCG2 function and inhibition.
Cancer Res. 2004 Feb 15;64(4):1242-6., 2004-02-15 [PMID:14973080]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Ee PL, Kamalakaran S, Tonetti D, He X, Ross DD, Beck WT
Identification of a novel estrogen response element in the breast cancer resistance protein (ABCG2) gene.
Cancer Res. 2004 Feb 15;64(4):1247-51., 2004-02-15 [PMID:14973083]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Bates SE, Medina-Perez WY, Kohlhagen G, Antony S, Nadjem T, Robey RW, Pommier Y
ABCG2 mediates differential resistance to SN-38 (7-ethyl-10-hydroxycamptothecin) and homocamptothecins.
J Pharmacol Exp Ther. 2004 Aug;310(2):836-42. Epub 2004 Apr 9., [PMID:15075385]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Sarkadi B, Ozvegy-Laczka C, Nemet K, Varadi A
ABCG2 -- a transporter for all seasons.
FEBS Lett. 2004 Jun 1;567(1):116-20., 2004-06-01 [PMID:15165903]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Burger H, van Tol H, Boersma AW, Brok M, Wiemer EA, Stoter G, Nooter K
Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump.
Blood. 2004 Nov 1;104(9):2940-2. Epub 2004 Jul 13., 2004-11-01 [PMID:15251980]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Polgar O, Robey RW, Morisaki K, Dean M, Michejda C, Sauna ZE, Ambudkar SV, Tarasova N, Bates SE
Mutational analysis of ABCG2: role of the GXXXG motif.
Biochemistry. 2004 Jul 27;43(29):9448-56., 2004-07-27 [PMID:15260487]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Janvilisri T, Shahi S, Venter H, Balakrishnan L, van Veen HW
Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein (ABCG2).
Biochem J. 2005 Jan 15;385(Pt 2):419-26., 2005-01-15 [PMID:15362954]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Walter RB, Raden BW, Thompson J, Flowers DA, Kiem HP, Bernstein ID, Linenberger ML
Breast cancer resistance protein (BCRP/ABCG2) does not confer resistance to gemtuzumab ozogamicin and calicheamicin-gamma1 in acute myeloid leukemia cells.
Leukemia. 2004 Nov;18(11):1914-7., [PMID:15385942]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Kobayashi D, Ieiri I, Hirota T, Takane H, Maegawa S, Kigawa J, Suzuki H, Nanba E, Oshimura M, Terakawa N, Otsubo K, Mine K, Sugiyama Y
Functional assessment of ABCG2 (BCRP) gene polymorphisms to protein expression in human placenta.
Drug Metab Dispos. 2005 Jan;33(1):94-101. Epub 2004 Oct 8., [PMID:15475413]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Loganzo F, Hari M, Annable T, Tan X, Morilla DB, Musto S, Zask A, Kaplan J, Minnick AA Jr, May MK, Ayral-Kaloustian S, Poruchynsky MS, Fojo T, Greenberger LM
Cells resistant to HTI-286 do not overexpress P-glycoprotein but have reduced drug accumulation and a point mutation in alpha-tubulin.
Mol Cancer Ther. 2004 Oct;3(10):1319-27., [PMID:15486199]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Ueda T, Brenner S, Malech HL, Langemeijer SM, Perl S, Kirby M, Phang OA, Krouse AE, Donahue RE, Kang EM, Tisdale JF
Cloning and functional analysis of the rhesus macaque ABCG2 gene. Forced expression confers an SP phenotype among hematopoietic stem cell progeny in vivo.
J Biol Chem. 2005 Jan 14;280(2):991-8. Epub 2004 Oct 30., 2005-01-14 [PMID:15516692]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Garcia-Escarp M, Martinez-Munoz V, Sales-Pardo I, Barquinero J, Domingo JC, Marin P, Petriz J
Flow cytometry-based approach to ABCG2 function suggests that the transporter differentially handles the influx and efflux of drugs.
Cytometry A. 2004 Dec;62(2):129-38., [PMID:15517563]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Ozvegy-Laczka C, Varady G, Koblos G, Ujhelly O, Cervenak J, Schuetz JD, Sorrentino BP, Koomen GJ, Varadi A, Nemet K, Sarkadi B
Function-dependent conformational changes of the ABCG2 multidrug transporter modify its interaction with a monoclonal antibody on the cell surface.
J Biol Chem. 2005 Feb 11;280(6):4219-27. Epub 2004 Nov 22., 2005-02-11 [PMID:15557326]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Rhee MS, Schneider E
Lack of an effect of breast cancer resistance protein (BCRP/ABCG2) overexpression on methotrexate polyglutamate export and folate accumulation in a human breast cancer cell line.
Biochem Pharmacol. 2005 Jan 1;69(1):123-32., 2005-01-01 [PMID:15588721]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Ejendal KF, Hrycyna CA
Differential sensitivities of the human ATP-binding cassette transporters ABCG2 and P-glycoprotein to cyclosporin A.
Mol Pharmacol. 2005 Mar;67(3):902-11. Epub 2004 Dec 14., [PMID:15598974]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Itoda M, Saito Y, Shirao K, Minami H, Ohtsu A, Yoshida T, Saijo N, Suzuki H, Sugiyama Y, Ozawa S, Sawada J
Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotacan.
Drug Metab Pharmacokinet. 2003;18(3):212-7., [PMID:15618737]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Kager L, Cheok M, Yang W, Zaza G, Cheng Q, Panetta JC, Pui CH, Downing JR, Relling MV, Evans WE
Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics.
J Clin Invest. 2005 Jan;115(1):110-7., [PMID:15630450]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Ozvegy-Laczka C, Koblos G, Sarkadi B, Varadi A
Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition.
Biochim Biophys Acta. 2005 Feb 1;1668(1):53-63., 2005-02-01 [PMID:15670731]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Robey RW, Steadman K, Polgar O, Bates SE
ABCG2-mediated transport of photosensitizers: potential impact on photodynamic therapy.
Cancer Biol Ther. 2005 Feb;4(2):187-94. Epub 2005 Feb 8., [PMID:15684613]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Staud F, Pavek P
Breast cancer resistance protein (BCRP/ABCG2).
Int J Biochem Cell Biol. 2005 Apr;37(4):720-5., [PMID:15694832]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Xia CQ, Liu N, Yang D, Miwa G, Gan LS
Expression, localization, and functional characteristics of breast cancer resistance protein in Caco-2 cells.
Drug Metab Dispos. 2005 May;33(5):637-43. Epub 2005 Feb 16., [PMID:15716365]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Henriksen U, Gether U, Litman T
Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2.
J Cell Sci. 2005 Apr 1;118(Pt 7):1417-26. Epub 2005 Mar 15., 2005-04-01 [PMID:15769853]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Diop NK, Hrycyna CA
N-Linked glycosylation of the human ABC transporter ABCG2 on asparagine 596 is not essential for expression, transport activity, or trafficking to the plasma membrane.
Biochemistry. 2005 Apr 12;44(14):5420-9., 2005-04-12 [PMID:15807535]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Morisaki K, Robey RW, Ozvegy-Laczka C, Honjo Y, Polgar O, Steadman K, Sarkadi B, Bates SE
Single nucleotide polymorphisms modify the transporter activity of ABCG2.
Cancer Chemother Pharmacol. 2005 Aug;56(2):161-72. Epub 2005 Apr 19., [PMID:15838659]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Lepper ER, Nooter K, Verweij J, Acharya MR, Figg WD, Sparreboom A
Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2.
Pharmacogenomics. 2005 Mar;6(2):115-38., [PMID:15882131]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Ahmed-Belkacem A, Pozza A, Munoz-Martinez F, Bates SE, Castanys S, Gamarro F, Di Pietro A, Perez-Victoria JM
Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2.
Cancer Res. 2005 Jun 1;65(11):4852-60., 2005-06-01 [PMID:15930306]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Bhatia A, Schafer HJ, Hrycyna CA
Oligomerization of the human ABC transporter ABCG2: evaluation of the native protein and chimeric dimers.
Biochemistry. 2005 Aug 16;44(32):10893-904., 2005-08-16 [PMID:16086592]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Henriksen U, Fog JU, Litman T, Gether U
Identification of intra- and intermolecular disulfide bridges in the multidrug resistance transporter ABCG2.
J Biol Chem. 2005 Nov 4;280(44):36926-34. Epub 2005 Aug 17., 2005-11-04 [PMID:16107343]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Sugimoto Y, Tsukahara S, Ishikawa E, Mitsuhashi J
Breast cancer resistance protein: molecular target for anticancer drug resistance and pharmacokinetics/pharmacodynamics.
Cancer Sci. 2005 Aug;96(8):457-65., [PMID:16108826]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Mao Q, Unadkat JD
Role of the breast cancer resistance protein (ABCG2) in drug transport.
AAPS J. 2005 May 11;7(1):E118-33., [PMID:16146333]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Krishnamurthy P, Schuetz JD
The ABC transporter Abcg2/Bcrp: role in hypoxia mediated survival.
Biometals. 2005 Aug;18(4):349-58., [PMID:16158227]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Ishikawa T, Tamura A, Saito H, Wakabayashi K, Nakagawa H
Pharmacogenomics of the human ABC transporter ABCG2: from functional evaluation to drug molecular design.
Naturwissenschaften. 2005 Oct;92(10):451-63., [PMID:16160819]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Huang Y, Sadee W
Membrane transporters and channels in chemoresistance and -sensitivity of tumor cells.
Cancer Lett. 2006 Aug 8;239(2):168-82. Epub 2005 Oct 5., 2006-08-08 [PMID:16169662]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Sakurai A, Tamura A, Onishi Y, Ishikawa T
Genetic polymorphisms of ATP-binding cassette transporters ABCB1 and ABCG2: therapeutic implications.
Expert Opin Pharmacother. 2005 Nov;6(14):2455-73., [PMID:16259577]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Breedveld P, Beijnen JH, Schellens JH
Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs.
Trends Pharmacol Sci. 2006 Jan;27(1):17-24. Epub 2005 Dec 5., [PMID:16337012]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Cervenak J, Andrikovics H, Ozvegy-Laczka C, Tordai A, Nemet K, Varadi A, Sarkadi B
The role of the human ABCG2 multidrug transporter and its variants in cancer therapy and toxicology.
Cancer Lett. 2006 Mar 8;234(1):62-72. Epub 2005 Dec 7., 2006-03-08 [PMID:16337740]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Ishikawa T, Sakurai A, Kanamori Y, Nagakura M, Hirano H, Takarada Y, Yamada K, Fukushima K, Kitajima M
High-speed screening of human ATP-binding cassette transporter function and genetic polymorphisms: new strategies in pharmacogenomics.
Methods Enzymol. 2005;400:485-510., [PMID:16399366]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Gupta A, Dai Y, Vethanayagam RR, Hebert MF, Thummel KE, Unadkat JD, Ross DD, Mao Q
Cyclosporin A, tacrolimus and sirolimus are potent inhibitors of the human breast cancer resistance protein (ABCG2) and reverse resistance to mitoxantrone and topotecan.
Cancer Chemother Pharmacol. 2006 Sep;58(3):374-83. Epub 2006 Jan 11., [PMID:16404634]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Cooray HC, Shahi S, Cahn AP, van Veen HW, Hladky SB, Barrand MA
Modulation of p-glycoprotein and breast cancer resistance protein by some prescribed corticosteroids.
Eur J Pharmacol. 2006 Feb 15;531(1-3):25-33. Epub 2006 Jan 25., 2006-02-15 [PMID:16442095]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Saito H, Hirano H, Nakagawa H, Fukami T, Oosumi K, Murakami K, Kimura H, Kouchi T, Konomi M, Tao E, Tsujikawa N, Tarui S, Nagakura M, Osumi M, Ishikawa T
A new strategy of high-speed screening and quantitative structure-activity relationship analysis to evaluate human ATP-binding cassette transporter ABCG2-drug interactions.
J Pharmacol Exp Ther. 2006 Jun;317(3):1114-24. Epub 2006 Feb 17., [PMID:16489126]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Ahmed-Belkacem A, Pozza A, Macalou S, Perez-Victoria JM, Boumendjel A, Di Pietro A
Inhibitors of cancer cell multidrug resistance mediated by breast cancer resistance protein (BCRP/ABCG2).
Anticancer Drugs. 2006 Mar;17(3):239-43., [PMID:16520651]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Tamura A, Watanabe M, Saito H, Nakagawa H, Kamachi T, Okura I, Ishikawa T
Functional validation of the genetic polymorphisms of human ATP-binding cassette (ABC) transporter ABCG2: identification of alleles that are defective in porphyrin transport.
Mol Pharmacol. 2006 Jul;70(1):287-96. Epub 2006 Apr 11., [PMID:16608919]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Maekawa K, Itoda M, Sai K, Saito Y, Kaniwa N, Shirao K, Hamaguchi T, Kunitoh H, Yamamoto N, Tamura T, Minami H, Kubota K, Ohtsu A, Yoshida T, Saijo N, Kamatani N, Ozawa S, Sawada J
Genetic variation and haplotype structure of the ABC transporter gene ABCG2 in a Japanese population.
Drug Metab Pharmacokinet. 2006 Apr;21(2):109-21., [PMID:16702730]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Asashima T, Hori S, Ohtsuki S, Tachikawa M, Watanabe M, Mukai C, Kitagaki S, Miyakoshi N, Terasaki T
ATP-binding cassette transporter G2 mediates the efflux of phototoxins on the luminal membrane of retinal capillary endothelial cells.
Pharm Res. 2006 Jun;23(6):1235-42. Epub 2006 May 25., [PMID:16715370]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Ejendal KF, Diop NK, Schweiger LC, Hrycyna CA
The nature of amino acid 482 of human ABCG2 affects substrate transport and ATP hydrolysis but not substrate binding.
Protein Sci. 2006 Jul;15(7):1597-607., [PMID:16815914]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Perez-Tomas R
Multidrug resistance: retrospect and prospects in anti-cancer drug treatment.
Curr Med Chem. 2006;13(16):1859-76., [PMID:16842198]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Xia CQ, Yang JJ, Gan LS
Breast cancer resistance protein in pharmacokinetics and drug-drug interactions.
Expert Opin Drug Metab Toxicol. 2005 Dec;1(4):595-611., [PMID:16863427]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Wakabayashi K, Tamura A, Saito H, Onishi Y, Ishikawa T
Human ABC transporter ABCG2 in xenobiotic protection and redox biology.
Drug Metab Rev. 2006;38(3):371-91., [PMID:16877258]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Clark R, Kerr ID, Callaghan R
Multiple drugbinding sites on the R482G isoform of the ABCG2 transporter.
Br J Pharmacol. 2006 Nov;149(5):506-15. Epub 2006 Sep 18., [PMID:16981002]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Kusuhara H, Sugiyama Y
ATP-binding cassette, subfamily G (ABCG family).
Pflugers Arch. 2007 Feb;453(5):735-44. Epub 2006 Sep 16., [PMID:16983557]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Sarkadi B, Homolya L, Szakacs G, Varadi A
Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system.
Physiol Rev. 2006 Oct;86(4):1179-236., [PMID:17015488]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Li YF, Polgar O, Okada M, Esser L, Bates SE, Xia D
Towards understanding the mechanism of action of the multidrug resistance-linked half-ABC transporter ABCG2: a molecular modeling study.
J Mol Graph Model. 2007 Mar;25(6):837-51. Epub 2006 Aug 30., [PMID:17027309]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Breedveld P, Pluim D, Cipriani G, Dahlhaus F, van Eijndhoven MA, de Wolf CJ, Kuil A, Beijnen JH, Scheffer GL, Jansen G, Borst P, Schellens JH
The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models.
Mol Pharmacol. 2007 Jan;71(1):240-9. Epub 2006 Oct 10., [PMID:17032904]

Abstract [show]
Comments [show]
Sentences [show]

[hide] McDevitt CA, Collins RF, Conway M, Modok S, Storm J, Kerr ID, Ford RC, Callaghan R
Purification and 3D structural analysis of oligomeric human multidrug transporter ABCG2.
Structure. 2006 Nov;14(11):1623-32., [PMID:17098188]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Tamura A, Wakabayashi K, Onishi Y, Nakagawa H, Tsuji M, Matsuda Y, Ishikawa T
Genetic polymorphisms of human ABC transporter ABCG2: development of the standard method for functional validation of SNPs by using the Flp recombinase system.
J Exp Ther Oncol. 2006;6(1):1-11., [PMID:17228519]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Tamura A, Wakabayashi K, Onishi Y, Takeda M, Ikegami Y, Sawada S, Tsuji M, Matsuda Y, Ishikawa T
Re-evaluation and functional classification of non-synonymous single nucleotide polymorphisms of the human ATP-binding cassette transporter ABCG2.
Cancer Sci. 2007 Feb;98(2):231-9., [PMID:17297656]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Huang Y
Pharmacogenetics/genomics of membrane transporters in cancer chemotherapy.
Cancer Metastasis Rev. 2007 Mar;26(1):183-201., [PMID:17323126]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Pal A, Mehn D, Molnar E, Gedey S, Meszaros P, Nagy T, Glavinas H, Janaky T, von Richter O, Bathori G, Szente L, Krajcsi P
Cholesterol potentiates ABCG2 activity in a heterologous expression system: improved in vitro model to study function of human ABCG2.
J Pharmacol Exp Ther. 2007 Jun;321(3):1085-94. Epub 2007 Mar 8., [PMID:17347325]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Hardwick LJ, Velamakanni S, van Veen HW
The emerging pharmacotherapeutic significance of the breast cancer resistance protein (ABCG2).
Br J Pharmacol. 2007 May;151(2):163-74. Epub 2007 Mar 20., [PMID:17375082]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Lee G, Babakhanian K, Ramaswamy M, Prat A, Wosik K, Bendayan R
Expression of the ATP-binding cassette membrane transporter, ABCG2, in human and rodent brain microvessel endothelial and glial cell culture systems.
Pharm Res. 2007 Jul;24(7):1262-74. Epub 2007 Mar 23., [PMID:17380269]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Yeboah D, Sun M, Kingdom J, Baczyk D, Lye SJ, Matthews SG, Gibb W
Expression of breast cancer resistance protein (BCRP/ABCG2) in human placenta throughout gestation and at term before and after labor.
Can J Physiol Pharmacol. 2006 Dec;84(12):1251-8., [PMID:17487233]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Xia CQ, Milton MN, Gan LS
Evaluation of drug-transporter interactions using in vitro and in vivo models.
Curr Drug Metab. 2007 May;8(4):341-63., [PMID:17504223]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Glavinas H, Kis E, Pal A, Kovacs R, Jani M, Vagi E, Molnar E, Bansaghi S, Kele Z, Janaky T, Bathori G, von Richter O, Koomen GJ, Krajcsi P
ABCG2 (breast cancer resistance protein/mitoxantrone resistance-associated protein) ATPase assay: a useful tool to detect drug-transporter interactions.
Drug Metab Dispos. 2007 Sep;35(9):1533-42. Epub 2007 May 30., [PMID:17537873]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Matsson P, Englund G, Ahlin G, Bergstrom CA, Norinder U, Artursson P
A global drug inhibition pattern for the human ATP-binding cassette transporter breast cancer resistance protein (ABCG2).
J Pharmacol Exp Ther. 2007 Oct;323(1):19-30. Epub 2007 Jul 6., [PMID:17616561]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Telbisz A, Muller M, Ozvegy-Laczka C, Homolya L, Szente L, Varadi A, Sarkadi B
Membrane cholesterol selectively modulates the activity of the human ABCG2 multidrug transporter.
Biochim Biophys Acta. 2007 Nov;1768(11):2698-713. Epub 2007 Jul 10., [PMID:17662239]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Korynevska A, Heffeter P, Matselyukh B, Elbling L, Micksche M, Stoika R, Berger W
Mechanisms underlying the anticancer activities of the angucycline landomycin E.
Biochem Pharmacol. 2007 Dec 15;74(12):1713-26. Epub 2007 Aug 25., 2007-12-15 [PMID:17904109]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Zhang Y, Bressler JP, Neal J, Lal B, Bhang HE, Laterra J, Pomper MG
ABCG2/BCRP expression modulates D-Luciferin based bioluminescence imaging.
Cancer Res. 2007 Oct 1;67(19):9389-97., 2007-10-01 [PMID:17909048]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Gedeon C, Anger G, Piquette-Miller M, Koren G
Breast cancer resistance protein: mediating the trans-placental transfer of glyburide across the human placenta.
Placenta. 2008 Jan;29(1):39-43. Epub 2007 Oct 17., [PMID:17923155]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Gounder MK, Nazar AS, Saleem A, Pungaliya P, Kulkarni D, Versace R, Rubin EH
Effects of drug efflux proteins and topoisomerase I mutations on the camptothecin analogue gimatecan.
Invest New Drugs. 2008 Jun;26(3):205-13. Epub 2007 Oct 18., [PMID:17943230]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Saito H, Hirano H, Ishikawa T
High-speed screening and quantitative SAR analysis of human ABC transporter ABCG2 for molecular modeling of anticancer drugs to circumvent multidrug resistance.
Mini Rev Med Chem. 2007 Oct;7(10):1009-18., [PMID:17979803]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Shi Z, Peng XX, Kim IW, Shukla S, Si QS, Robey RW, Bates SE, Shen T, Ashby CR Jr, Fu LW, Ambudkar SV, Chen ZS
Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance.
Cancer Res. 2007 Nov 15;67(22):11012-20., 2007-11-15 [PMID:18006847]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Wu CP, Shukla S, Calcagno AM, Hall MD, Gottesman MM, Ambudkar SV
Evidence for dual mode of action of a thiosemicarbazone, NSC73306: a potent substrate of the multidrug resistance linked ABCG2 transporter.
Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3287-96., [PMID:18089722]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Sharom FJ
ABC multidrug transporters: structure, function and role in chemoresistance.
Pharmacogenomics. 2008 Jan;9(1):105-27., [PMID:18154452]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Nakagawa H, Tamura A, Wakabayashi K, Hoshijima K, Komada M, Yoshida T, Kometani S, Matsubara T, Mikuriya K, Ishikawa T
Ubiquitin-mediated proteasomal degradation of non-synonymous SNP variants of human ABC transporter ABCG2.
Biochem J. 2008 May 1;411(3):623-31., 2008-05-01 [PMID:18237272]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Hazai E, Bikadi Z
Homology modeling of breast cancer resistance protein (ABCG2).
J Struct Biol. 2008 Apr;162(1):63-74. Epub 2007 Dec 15., [PMID:18249138]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Lemos C, Jansen G, Peters GJ
Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors.
Br J Cancer. 2008 Mar 11;98(5):857-62. Epub 2008 Feb 5., 2008-03-11 [PMID:18253130]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Tamura A, An R, Hagiya Y, Hoshijima K, Yoshida T, Mikuriya K, Ishikawa T
Drug-induced phototoxicity evoked by inhibition of human ABC transporter ABCG2: development of in vitro high-speed screening systems.
Expert Opin Drug Metab Toxicol. 2008 Mar;4(3):255-72., [PMID:18363541]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Liu Y, Yang Y, Qi J, Peng H, Zhang JT
Effect of cysteine mutagenesis on the function and disulfide bond formation of human ABCG2.
J Pharmacol Exp Ther. 2008 Jul;326(1):33-40. Epub 2008 Apr 22., [PMID:18430864]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Muenster U, Grieshop B, Ickenroth K, Gnoth MJ
Characterization of substrates and inhibitors for the in vitro assessment of Bcrp mediated drug-drug interactions.
Pharm Res. 2008 Oct;25(10):2320-6. Epub 2008 Jun 4., [PMID:18523872]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Ozvegy-Laczka C, Laczko R, Hegedus C, Litman T, Varady G, Goda K, Hegedus T, Dokholyan NV, Sorrentino BP, Varadi A, Sarkadi B
Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter.
J Biol Chem. 2008 Sep 19;283(38):26059-70. Epub 2008 Jul 21., 2008-09-19 [PMID:18644784]

Abstract [show]
Comments [show]
Sentences [show]

[hide] McDevitt CA, Crowley E, Hobbs G, Starr KJ, Kerr ID, Callaghan R
Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?
FEBS J. 2008 Sep;275(17):4354-62. Epub 2008 Jul 24., [PMID:18657189]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Koshiba S, An R, Saito H, Wakabayashi K, Tamura A, Ishikawa T
Human ABC transporters ABCG2 (BCRP) and ABCG4.
Xenobiotica. 2008 Jul;38(7-8):863-88., [PMID:18668433]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Nakamura T, Yamamori M, Sakaeda T
Pharmacogenetics of intestinal absorption.
Curr Drug Deliv. 2008 Jul;5(3):153-69., [PMID:18673259]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Merino G, Real R, Baro MF, Gonzalez-Lobato L, Prieto JG, Alvarez AI, Marques MM
Natural allelic variants of bovine ATP-binding cassette transporter ABCG2: increased activity of the Ser581 variant and development of tools for the discovery of new ABCG2 inhibitors.
Drug Metab Dispos. 2009 Jan;37(1):5-9. Epub 2008 Sep 29., [PMID:18824523]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Dai CL, Tiwari AK, Wu CP, Su XD, Wang SR, Liu DG, Ashby CR Jr, Huang Y, Robey RW, Liang YJ, Chen LM, Shi CJ, Ambudkar SV, Chen ZS, Fu LW
Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2.
Cancer Res. 2008 Oct 1;68(19):7905-14., 2008-10-01 [PMID:18829547]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Zhou SF, Di YM, Chan E, Du YM, Chow VD, Xue CC, Lai X, Wang JC, Li CG, Tian M, Duan W
Clinical pharmacogenetics and potential application in personalized medicine.
Curr Drug Metab. 2008 Oct;9(8):738-84., [PMID:18855611]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Furukawa T, Wakabayashi K, Tamura A, Nakagawa H, Morishima Y, Osawa Y, Ishikawa T
Major SNP (Q141K) variant of human ABC transporter ABCG2 undergoes lysosomal and proteasomal degradations.
Pharm Res. 2009 Feb;26(2):469-79. Epub 2008 Oct 29., [PMID:18958403]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Polgar O, Deeken JF, Ediriwickrema LS, Tamaki A, Steinberg SM, Robey RW, Bates SE
The 315-316 deletion determines the BXP-21 antibody epitope but has no effect on the function of wild type ABCG2 or the Q141K variant.
Mol Cell Biochem. 2009 Feb;322(1-2):63-71. Epub 2008 Nov 11., [PMID:19002564]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Giri N, Agarwal S, Shaik N, Pan G, Chen Y, Elmquist WF
Substrate-dependent breast cancer resistance protein (Bcrp1/Abcg2)-mediated interactions: consideration of multiple binding sites in in vitro assay design.
Drug Metab Dispos. 2009 Mar;37(3):560-70. Epub 2008 Dec 4., [PMID:19056916]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Shi Z, Tiwari AK, Shukla S, Robey RW, Kim IW, Parmar S, Bates SE, Si QS, Goldblatt CS, Abraham I, Fu LW, Ambudkar SV, Chen ZS
Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478.
Biochem Pharmacol. 2009 Mar 1;77(5):781-93. Epub 2008 Nov 18., 2009-03-01 [PMID:19059384]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Noguchi K, Katayama K, Mitsuhashi J, Sugimoto Y
Functions of the breast cancer resistance protein (BCRP/ABCG2) in chemotherapy.
Adv Drug Deliv Rev. 2009 Jan 31;61(1):26-33. Epub 2008 Dec 3., 2009-01-31 [PMID:19111841]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Wakabayashi-Nakao K, Tamura A, Furukawa T, Nakagawa H, Ishikawa T
Quality control of human ABCG2 protein in the endoplasmic reticulum: ubiquitination and proteasomal degradation.
Adv Drug Deliv Rev. 2009 Jan 31;61(1):66-72. Epub 2008 Dec 11., 2009-01-31 [PMID:19111842]

Abstract [show]
Comments [show]
Sentences [show]

[hide] McDevitt CA, Collins R, Kerr ID, Callaghan R
Purification and structural analyses of ABCG2.
Adv Drug Deliv Rev. 2009 Jan 31;61(1):57-65. Epub 2008 Dec 13., 2009-01-31 [PMID:19124053]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Hegedus C, Szakacs G, Homolya L, Orban TI, Telbisz A, Jani M, Sarkadi B
Ins and outs of the ABCG2 multidrug transporter: an update on in vitro functional assays.
Adv Drug Deliv Rev. 2009 Jan 31;61(1):47-56. Epub 2008 Dec 24., 2009-01-31 [PMID:19135105]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Nicolle E, Boumendjel A, Macalou S, Genoux E, Ahmed-Belkacem A, Carrupt PA, Di Pietro A
QSAR analysis and molecular modeling of ABCG2-specific inhibitors.
Adv Drug Deliv Rev. 2009 Jan 31;61(1):34-46. Epub 2008 Dec 16., 2009-01-31 [PMID:19135106]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Day JM, Foster PA, Tutill HJ, Newman SP, Ho YT, Leese MP, Potter BV, Reed MJ, Purohit A
BCRP expression does not result in resistance to STX140 in vivo, despite the increased expression of BCRP in A2780 cells in vitro after long-term STX140 exposure.
Br J Cancer. 2009 Feb 10;100(3):476-86. Epub 2009 Jan 20., 2009-02-10 [PMID:19156141]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Dai CL, Liang YJ, Wang YS, Tiwari AK, Yan YY, Wang F, Chen ZS, Tong XZ, Fu LW
Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2.
Cancer Lett. 2009 Jun 28;279(1):74-83. Epub 2009 Feb 18., 2009-06-28 [PMID:19232821]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Bram EE, Adar Y, Mesika N, Sabisz M, Skladanowski A, Assaraf YG
Structural determinants of imidazoacridinones facilitating antitumor activity are crucial for substrate recognition by ABCG2.
Mol Pharmacol. 2009 May;75(5):1149-59. Epub 2009 Feb 27., [PMID:19251825]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Mathew G, Timm EA Jr, Sotomayor P, Godoy A, Montecinos VP, Smith GJ, Huss WJ
ABCG2-mediated DyeCycle Violet efflux defined side population in benign and malignant prostate.
Cell Cycle. 2009 Apr 1;8(7):1053-61. Epub 2009 Apr 30., 2009-04-01 [PMID:19270533]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Polgar O, Ediriwickrema LS, Robey RW, Sharma A, Hegde RS, Li Y, Xia D, Ward Y, Dean M, Ozvegy-Laczka C, Sarkadi B, Bates SE
Arginine 383 is a crucial residue in ABCG2 biogenesis.
Biochim Biophys Acta. 2009 Jul;1788(7):1434-43. Epub 2009 May 3., [PMID:19406100]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Tiwari AK, Sodani K, Wang SR, Kuang YH, Ashby CR Jr, Chen X, Chen ZS
Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters.
Biochem Pharmacol. 2009 Jul 15;78(2):153-61. Epub 2009 Apr 11., 2009-07-15 [PMID:19427995]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Ishikawa T, Nakagawa H
Human ABC transporter ABCG2 in cancer chemotherapy and pharmacogenomics.
J Exp Ther Oncol. 2009;8(1):5-24., [PMID:19827267]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Calcagno AM, Ambudkar SV
Molecular mechanisms of drug resistance in single-step and multi-step drug-selected cancer cells.
Methods Mol Biol. 2010;596:77-93., [PMID:19949921]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Ross DD, Nakanishi T
Impact of breast cancer resistance protein on cancer treatment outcomes.
Methods Mol Biol. 2010;596:251-90., [PMID:19949928]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Polgar O, Ierano C, Tamaki A, Stanley B, Ward Y, Xia D, Tarasova N, Robey RW, Bates SE
Mutational analysis of threonine 402 adjacent to the GXXXG dimerization motif in transmembrane segment 1 of ABCG2.
Biochemistry. 2010 Mar 16;49(10):2235-45., 2010-03-16 [PMID:20088606]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Cai X, Bikadi Z, Ni Z, Lee EW, Wang H, Rosenberg MF, Mao Q
Role of basic residues within or near the predicted transmembrane helix 2 of the human breast cancer resistance protein in drug transport.
J Pharmacol Exp Ther. 2010 Jun;333(3):670-81. Epub 2010 Mar 4., [PMID:20203106]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Kawahara H, Noguchi K, Katayama K, Mitsuhashi J, Sugimoto Y
Pharmacological interaction with sunitinib is abolished by a germ-line mutation (1291T>C) of BCRP/ABCG2 gene.
Cancer Sci. 2010 Jun;101(6):1493-500. Epub 2010 Feb 22., [PMID:20345483]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Ni Z, Bikadi Z, Rosenberg MF, Mao Q
Structure and function of the human breast cancer resistance protein (BCRP/ABCG2).
Curr Drug Metab. 2010 Sep;11(7):603-17., [PMID:20812902]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Mi YJ, Liang YJ, Huang HB, Zhao HY, Wu CP, Wang F, Tao LY, Zhang CZ, Dai CL, Tiwari AK, Ma XX, To KK, Ambudkar SV, Chen ZS, Fu LW
Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters.
Cancer Res. 2010 Oct 15;70(20):7981-91. Epub 2010 Sep 28., 2010-10-15 [PMID:20876799]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Meyer zu Schwabedissen HE, Kroemer HK
In vitro and in vivo evidence for the importance of breast cancer resistance protein transporters (BCRP/MXR/ABCP/ABCG2).
Handb Exp Pharmacol. 2011;(201):325-71., [PMID:21103975]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Kerr ID, Haider AJ, Gelissen IC
The ABCG family of membrane-associated transporters: you don't have to be big to be mighty.
Br J Pharmacol. 2010 Dec 22. doi: 10.1111/j.1476-5381.2010.01177.x., 2010-12-22 [PMID:21175590]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Ishikawa T, Nakagawa H, Hagiya Y, Nonoguchi N, Miyatake S, Kuroiwa T
Key Role of Human ABC Transporter ABCG2 in Photodynamic Therapy and Photodynamic Diagnosis.
Adv Pharmacol Sci. 2010;2010:587306. Epub 2010 Jul 8., [PMID:21188243]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Shi Z, Tiwari AK, Shukla S, Robey RW, Singh S, Kim IW, Bates SE, Peng X, Abraham I, Ambudkar SV, Talele TT, Fu LW, Chen ZS
Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance.
Cancer Res. 2011 Apr 15;71(8):3029-41. Epub 2011 Mar 14., 2011-04-15 [PMID:21402712]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Jacobs A, Emmert D, Wieschrath S, Hrycyna CA, Wiese M
Recombinant synthesis of human ABCG2 expressed in the yeast Saccharomyces cerevisiae: an experimental methodological study.
Protein J. 2011 Mar;30(3):201-11., [PMID:21424391]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Munic V, Hlevnjak M, Erakovic Haber V
Characterization of rhodamine-123, calcein and 5(6)-carboxy-2',7'-dichlorofluorescein (CDCF) export via MRP2 (ABCC2) in MES-SA and A549 cells.
Eur J Pharm Sci. 2011 Aug 17;43(5):359-69. doi: 10.1016/j.ejps.2011.05.003. Epub 2011 May 14., [PMID:21605668]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Haslam IS, Wright JA, O'Reilly DA, Sherlock DJ, Coleman T, Simmons NL
Intestinal ciprofloxacin efflux: the role of breast cancer resistance protein (ABCG2).
Drug Metab Dispos. 2011 Dec;39(12):2321-8. Epub 2011 Sep 19., [PMID:21930826]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Sun YL, Kathawala RJ, Singh S, Zheng K, Talele TT, Jiang WQ, Chen ZS
Zafirlukast antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance.
Anticancer Drugs. 2012 Sep;23(8):865-73., [PMID:22614107]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Hegedus C, Truta-Feles K, Antalffy G, Varady G, Nemet K, Ozvegy-Laczka C, Keri G, Orfi L, Szakacs G, Settleman J, Varadi A, Sarkadi B
Interaction of the EGFR inhibitors gefitinib, vandetanib, pelitinib and neratinib with the ABCG2 multidrug transporter: implications for the emergence and reversal of cancer drug resistance.
Biochem Pharmacol. 2012 Aug 1;84(3):260-7. Epub 2012 Apr 21., [PMID:22548830]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Wei Y, Ma Y, Zhao Q, Ren Z, Li Y, Hou T, Peng H
New use for an old drug: inhibiting ABCG2 with sorafenib.
Mol Cancer Ther. 2012 Aug;11(8):1693-702. Epub 2012 May 16., [PMID:22593228]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Wang F, Mi YJ, Chen XG, Wu XP, Liu Z, Chen SP, Liang YJ, Cheng C, To KK, Fu LW
Axitinib targeted cancer stemlike cells to enhance efficacy of chemotherapeutic drugs via inhibiting the drug transport function of ABCG2.
Mol Med. 2012 Jul 18;18(1):887-98. doi: 10.2119/molmed.2011.00444., [PMID:22549112]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Mo W, Qi J, Zhang JT
Different roles of TM5, TM6, and ECL3 in the oligomerization and function of human ABCG2.
Biochemistry. 2012 May 1;51(17):3634-41. Epub 2012 Apr 19., [PMID:22497316]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Fukuda Y, Schuetz JD
ABC transporters and their role in nucleoside and nucleotide drug resistance.
Biochem Pharmacol. 2012 Apr 15;83(8):1073-83. Epub 2012 Jan 20., [PMID:22285911]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Telbisz A, Hegedus C, Ozvegy-Laczka C, Goda K, Varady G, Takats Z, Szabo E, Sorrentino BP, Varadi A, Sarkadi B
Antibody binding shift assay for rapid screening of drug interactions with the human ABCG2 multidrug transporter.
Eur J Pharm Sci. 2012 Jan 23;45(1-2):101-9. Epub 2011 Nov 17., [PMID:22115866]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Mo W, Zhang JT
Human ABCG2: structure, function, and its role in multidrug resistance.
Int J Biochem Mol Biol. 2012;3(1):1-27. Epub 2011 Mar 30., [PMID:22509477]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Singh RR, Kunkalla K, Qu C, Schlette E, Neelapu SS, Samaniego F, Vega F
ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma.
Oncogene. 2011 Dec 8;30(49):4874-86. doi: 10.1038/onc.2011.195. Epub 2011 May 30., [PMID:21625222]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Li L, Sham YY, Bikadi Z, Elmquist WF
pH-Dependent transport of pemetrexed by breast cancer resistance protein.
Drug Metab Dispos. 2011 Sep;39(9):1478-85. Epub 2011 May 31., [PMID:21628496]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Wang F, Liang YJ, Wu XP, Chen LM, To KK, Dai CL, Yan YY, Wang YS, Tong XZ, Fu LW
Prognostic value of the multidrug resistance transporter ABCG2 gene polymorphisms in Chinese patients with de novo acute leukaemia.
Eur J Cancer. 2011 Sep;47(13):1990-9. Epub 2011 Apr 29., [PMID:21531129]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Poguntke M, Hazai E, Fromm MF, Zolk O
Drug transport by breast cancer resistance protein.
Expert Opin Drug Metab Toxicol. 2010 Nov;6(11):1363-84. Epub 2010 Sep 27., [PMID:20873966]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Choudhuri S, Klaassen CD
Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters.
Int J Toxicol. 2006 Jul-Aug;25(4):231-59., [PMID:16815813]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Tang R, Faussat AM, Perrot JY, Marjanovic Z, Cohen S, Storme T, Morjani H, Legrand O, Marie JP
Zosuquidar restores drug sensitivity in P-glycoprotein expressing acute myeloid leukemia (AML).
BMC Cancer. 2008 Feb 13;8:51., [PMID:18271955]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Velamakanni S, Janvilisri T, Shahi S, van Veen HW
A functional steroid-binding element in an ATP-binding cassette multidrug transporter.
Mol Pharmacol. 2008 Jan;73(1):12-7., [PMID:18094074]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Shi Z, Parmar S, Peng XX, Shen T, Robey RW, Bates SE, Fu LW, Shao Y, Chen YM, Zang F, Chen ZS
The epidermal growth factor tyrosine kinase inhibitor AG1478 and erlotinib reverse ABCG2-mediated drug resistance.
Oncol Rep. 2009 Feb;21(2):483-9., [PMID:19148526]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Real R, Gonzalez-Lobato L, Baro MF, Valbuena S, de la Fuente A, Prieto JG, Alvarez AI, Marques MM, Merino G
Analysis of the effect of the bovine adenosine triphosphate-binding cassette transporter G2 single nucleotide polymorphism Y581S on transcellular transport of veterinary drugs using new cell culture models.
J Anim Sci. 2011 Dec;89(12):4325-38. doi: 10.2527/jas.2011-3841. Epub 2011 Aug 5., [PMID:21821808]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Eddabra L, Wenner T, El Btaouri H, Baranek T, Madoulet C, Cornillet-Lefebvre P, Morjani H
Arginine 482 to glycine mutation in ABCG2/BCRP increases etoposide transport and resistance to the drug in HEK-293 cells.
Oncol Rep. 2012 Jan;27(1):232-7. doi: 10.3892/or.2011.1468. Epub 2011 Sep 20., [PMID:21935580]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Zhang Y, Pullambhatla M, Laterra J, Pomper MG
Influence of bioluminescence imaging dynamics by D-luciferin uptake and efflux mechanisms.
Mol Imaging. 2012 Nov-Dec;11(6):499-506., [PMID:23084250]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Wu CP, Sim HM, Huang YH, Liu YC, Hsiao SH, Cheng HW, Li YQ, Ambudkar SV, Hsu SC
Overexpression of ATP-binding cassette transporter ABCG2 as a potential mechanism of acquired resistance to vemurafenib in BRAF(V600E) mutant cancer cells.
Biochem Pharmacol. 2013 Feb 1;85(3):325-34. doi: 10.1016/j.bcp.2012.11.003. Epub 2012 Nov 12., [PMID:23153455]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Telbisz A, Ozvegy-Laczka C, Hegedus T, Varadi A, Sarkadi B
Effects of the lipid environment, cholesterol and bile acids on the function of the purified and reconstituted human ABCG2 protein.
Biochem J. 2013 Mar 1;450(2):387-95. doi: 10.1042/BJ20121485., [PMID:23205634]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Zoernig I, Ziegelmeier C, Lahrmann B, Grabe N, Jager D, Halama N
Sequence mutations of the substrate binding pocket of stem cell factor and multidrug resistance protein ABCG2 in renal cell cancer: a possible link to treatment resistance.
Oncol Rep. 2013 May;29(5):1697-700. doi: 10.3892/or.2013.2324. Epub 2013 Mar 5., [PMID:23467750]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Strouse JJ, Ivnitski-Steele I, Waller A, Young SM, Perez D, Evangelisti AM, Ursu O, Bologa CG, Carter MB, Salas VM, Tegos G, Larson RS, Oprea TI, Edwards BS, Sklar LA
Fluorescent substrates for flow cytometric evaluation of efflux inhibition in ABCB1, ABCC1, and ABCG2 transporters.
Anal Biochem. 2013 Jun 1;437(1):77-87. doi: 10.1016/j.ab.2013.02.018. Epub 2013 Mar 5., [PMID:23470221]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Hazai E, Hazai I, Ragueneau-Majlessi I, Chung SP, Bikadi Z, Mao Q
Predicting substrates of the human breast cancer resistance protein using a support vector machine method.
BMC Bioinformatics. 2013 Apr 15;14:130. doi: 10.1186/1471-2105-14-130., [PMID:23586520]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Stacy AE, Jansson PJ, Richardson DR
Molecular pharmacology of ABCG2 and its role in chemoresistance.
Mol Pharmacol. 2013 Nov;84(5):655-69. doi: 10.1124/mol.113.088609. Epub 2013 Sep 10., [PMID:24021215]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Telbisz A, Hegedus C, Varadi A, Sarkadi B, Ozvegy-Laczka C
Regulation of the function of the human ABCG2 multidrug transporter by cholesterol and bile acids: effects of mutations in potential substrate and steroid binding sites.
Drug Metab Dispos. 2014 Apr;42(4):575-85. doi: 10.1124/dmd.113.055731. Epub 2014 Jan 2., [PMID:24384916]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Deppe S, Ripperger A, Weiss J, Ergun S, Benndorf RA
Impact of genetic variability in the ABCG2 gene on ABCG2 expression, function, and interaction with AT1 receptor antagonist telmisartan.
Biochem Biophys Res Commun. 2014 Jan 24;443(4):1211-7. doi: 10.1016/j.bbrc.2013.12.119. Epub 2014 Jan 3., [PMID:24388985]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Gu YY, Liu LP, Qin J, Zhang M, Chen Y, Wang D, Li Z, Tang JZ, Mo SL
Baicalein decreases side population proportion via inhibition of ABCG2 in multiple myeloma cell line RPMI 8226 in vitro.
Fitoterapia. 2014 Apr;94:21-8. doi: 10.1016/j.fitote.2014.01.019. Epub 2014 Jan 25., [PMID:24468191]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Kathawala RJ, Chen JJ, Zhang YK, Wang YJ, Patel A, Wang DS, Talele TT, Ashby CR Jr, Chen ZS
Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance.
Int J Oncol. 2014 May;44(5):1634-42. doi: 10.3892/ijo.2014.2341. Epub 2014 Mar 13., [PMID:24626598]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Zhang H, Kathawala RJ, Wang YJ, Zhang YK, Patel A, Shukla S, Robey RW, Talele TT, Ashby CR Jr, Ambudkar SV, Bates SE, Fu LW, Chen ZS
Linsitinib (OSI-906) antagonizes ATP-binding cassette subfamily G member 2 and subfamily C member 10-mediated drug resistance.
Int J Biochem Cell Biol. 2014 Jun;51:111-9. doi: 10.1016/j.biocel.2014.03.026. Epub 2014 Apr 12., [PMID:24726739]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Zhang H, Wang YJ, Zhang YK, Wang DS, Kathawala RJ, Patel A, Talele TT, Chen ZS, Fu LW
AST1306, a potent EGFR inhibitor, antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance.
Cancer Lett. 2014 Aug 1;350(1-2):61-8. doi: 10.1016/j.canlet.2014.04.008. Epub 2014 Apr 18., [PMID:24747122]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Jani M, Ambrus C, Magnan R, Jakab KT, Beery E, Zolnerciks JK, Krajcsi P
Structure and function of BCRP, a broad specificity transporter of xenobiotics and endobiotics.
Arch Toxicol. 2014 Jun;88(6):1205-48. doi: 10.1007/s00204-014-1224-8. Epub 2014 Apr 29., [PMID:24777822]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Szafraniec MJ, Szczygiel M, Urbanska K, Fiedor L
Determinants of the activity and substrate recognition of breast cancer resistance protein (ABCG2).
Drug Metab Rev. 2014 Nov;46(4):459-74. doi: 10.3109/03602532.2014.942037. Epub 2014 Jul 18., [PMID:25036722]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Mao Q, Unadkat JD
Role of the breast cancer resistance protein (BCRP/ABCG2) in drug transport--an update.
AAPS J. 2015 Jan;17(1):65-82. doi: 10.1208/s12248-014-9668-6. Epub 2014 Sep 19., [PMID:25236865]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Gal Z, Hegedus C, Szakacs G, Varadi A, Sarkadi B, Ozvegy-Laczka C
Mutations of the central tyrosines of putative cholesterol recognition amino acid consensus (CRAC) sequences modify folding, activity, and sterol-sensing of the human ABCG2 multidrug transporter.
Biochim Biophys Acta. 2015 Feb;1848(2):477-87. doi: 10.1016/j.bbamem.2014.11.006. Epub 2014 Nov 14., [PMID:25445676]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Haider AJ, Cox MH, Jones N, Goode AJ, Bridge KS, Wong K, Briggs D, Kerr ID
Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences.
Biosci Rep. 2015 Jul 17;35(4). pii: e00241. doi: 10.1042/BSR20150150., [PMID:26294421]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Zhang W, Meng Y, Liu N, Wen XF, Yang T
Insights into Chemoresistance of Prostate Cancer.
Int J Biol Sci. 2015 Aug 1;11(10):1160-70. doi: 10.7150/ijbs.11439. eCollection 2015., [PMID:26327810]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Darby RA, Unsworth A, Knapp S, Kerr ID, Callaghan R
Overcoming ABCG2-mediated drug resistance with imidazo-[1,2-b]-pyridazine-based Pim1 kinase inhibitors.
Cancer Chemother Pharmacol. 2015 Oct;76(4):853-64. doi: 10.1007/s00280-015-2858-9. Epub 2015 Sep 9., [PMID:26351135]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Anreddy N, Patel A, Zhang YK, Wang YJ, Shukla S, Kathawala RJ, Kumar P, Gupta P, Ambudkar SV, Wurpel JN, Chen ZS, Guo H
A-803467, a tetrodotoxin-resistant sodium channel blocker, modulates ABCG2-mediated MDR in vitro and in vivo.
Oncotarget. 2015 Nov 17;6(36):39276-91. doi: 10.18632/oncotarget.5747., [PMID:26515463]

Abstract [show]
Comments [show]
Sentences [show]