PMID: 19156141

Day JM, Foster PA, Tutill HJ, Newman SP, Ho YT, Leese MP, Potter BV, Reed MJ, Purohit A
BCRP expression does not result in resistance to STX140 in vivo, despite the increased expression of BCRP in A2780 cells in vitro after long-term STX140 exposure.
Br J Cancer. 2009 Feb 10;100(3):476-86. Epub 2009 Jan 20., 2009-02-10 [PubMed]
Sentences
No. Mutations Sentence Comment
216 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 19156141:216:9
status: VERIFIED
view ABCG2 p.Arg482Thr details
ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 19156141:216:19
status: VERIFIED
view ABCG2 p.Arg482Gly details
 However, R482T and R482G mutations are found in the BCRP expressed by two well-characterised resistant cancer cell lines, MCF-7/AdrVp3000 (Lee et al, 1997) and S1-M1-80 (Miyake et al, 1999), respectively, selected by DOX and MXR treatment. Login to comment