PMID: 16337012

Breedveld P, Beijnen JH, Schellens JH
Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs.
Trends Pharmacol Sci. 2006 Jan;27(1):17-24. Epub 2005 Dec 5., [PubMed]
Sentences
No. Mutations Sentence Comment
35 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 16337012:35:182
status: VERIFIED
view ABCG2 p.Arg482Thr details
ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 16337012:35:201
status: VERIFIED
view ABCG2 p.Arg482Gly details
 Later studies revealed that the first cloned BCRP cDNA [28] encoded a mutant BCRP that deviated from the 'wild-type` BCRP at Arg482 (R482), which was replaced with either threonine (R482T) or glycine (R482G) [32,33]. Login to comment