PMID: 15630450

Kager L, Cheok M, Yang W, Zaza G, Cheng Q, Panetta JC, Pui CH, Downing JR, Relling MV, Evans WE
Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics.
J Clin Invest. 2005 Jan;115(1):110-7., [PubMed]
Sentences
No. Mutations Sentence Comment
130 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 15630450:130:69
status: NEW
view ABCG2 p.Arg482Thr details
ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 15630450:130:78
status: NEW
view ABCG2 p.Arg482Gly details
 It is noteworthy that only wild-type BCRP, but not the mutant forms (R482T or R482G), transports MTX and MTXPGs (13, 39). Login to comment