PMID: 17380269

Lee G, Babakhanian K, Ramaswamy M, Prat A, Wosik K, Bendayan R
Expression of the ATP-binding cassette membrane transporter, ABCG2, in human and rodent brain microvessel endothelial and glial cell culture systems.
Pharm Res. 2007 Jul;24(7):1262-74. Epub 2007 Mar 23., [PubMed]
Sentences
No. Mutations Sentence Comment
274 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 17380269:274:35
status: VERIFIED
view ABCG2 p.Arg482Thr details
ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 17380269:274:42
status: VERIFIED
view ABCG2 p.Arg482Gly details
 Although all three variants (R482, R482T, R482G) are able to transport mitoxantrone, wild-type ABCG2 is somewhat less effective in mitoxantrone extrusion than the other variants (37). Login to comment