PMID: 24626598

Kathawala RJ, Chen JJ, Zhang YK, Wang YJ, Patel A, Wang DS, Talele TT, Ashby CR Jr, Chen ZS
Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance.
Int J Oncol. 2014 May;44(5):1634-42. doi: 10.3892/ijo.2014.2341. Epub 2014 Mar 13., [PubMed]
Sentences
No. Mutations Sentence Comment
106 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 24626598:106:77
status: NEW
view ABCG2 p.Arg482Thr details
ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 24626598:106:87
status: NEW
view ABCG2 p.Arg482Gly details
 Therefore, in the present study, both wild-type (R482) and two mutant forms (R482T and R482G) of ABCG2 were used. Login to comment 110 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 24626598:110:104
status: NEW
view ABCG2 p.Arg482Thr details
 These results suggest that masitinib enhances the sensitivity of ABCG2 substrates in both wild-type and R482T/G mutant ABCG2 overexpressing cells, i.e. it selectively reverses MDR. Login to comment