ABCMdb

PMID: 12208758

Volk EL, Farley KM, Wu Y, Li F, Robey RW, Schneider E
Overexpression of wild-type breast cancer resistance protein mediates methotrexate resistance.
Cancer Res. 2002 Sep 1;62(17):5035-40., 2002-09-01 [PubMed]

Sentences

No. Mutations Sentence Comment

6 ABCG2 p.Arg482Thr ABCG2 p.Arg482Gly In contrast, little or no cross-resistance was found in the MCF7/AdVp1000 and S1-M1-3.2 and S1M1-80 cell lines, which contain acquired mutations at this position, R482T and R482G, respectively. Login to comment 7 ABCG2 p.Arg482Thr ABCG2 p.Arg482Gly In contrast, little or no cross-resistance was found in the MCF7/AdVp1000 and S1-M1-3.2 and S1M1-80 cell lines, which contain acquired mutations at this position, R482T and R482G, respectively. Login to comment 153 ABCG2 p.Arg482Ser ABCG2 p.Arg482Met Similar results were also seen in murine Bcrp1 R482M and R482S mutants (32). Login to comment 154 ABCG2 p.Arg482Ser ABCG2 p.Arg482Met Similar results were also seen in murine Bcrp1 R482M and R482S mutants (32). Login to comment 159 ABCG2 p.Arg482Thr However, the two BCRP-transfected clones used in the previous study (represented by the open diamonds in Fig. 1, B and C) were obtained using cDNA derived from the MCF7/ AdVp cells, before it was known that these cells contain the R482T mutation. Login to comment 160 ABCG2 p.Arg482Thr However, the two BCRP-transfected clones used in the previous study (represented by the open diamonds in Fig. 1, B and C) were obtained using cDNA derived from the MCF7/ AdVp cells, before it was known that these cells contain the R482T mutation. Login to comment 182 ABCG2 p.Arg482Thr ABCG2 p.Arg482Gly Additionally, we found that the R482T and R482G mutations in BCRP abolish MTX resistance. Login to comment 183 ABCG2 p.Arg482Thr ABCG2 p.Arg482Gly Additionally, we found that the R482T and R482G mutations in BCRP abolish MTX resistance. Login to comment