ABCMdb

PMID: 12488537

Wang X, Furukawa T, Nitanda T, Okamoto M, Sugimoto Y, Akiyama S, Baba M
Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors.
Mol Pharmacol. 2003 Jan;63(1):65-72., [PubMed]

Sentences

No. Mutations Sentence Comment

193 ABCG2 p.Arg482Thr ABCG2 p.Arg482Gly Increased efflux of doxorubicin and rhodamine 123 was observed with the R482T or R482G mutant but not with the wild type of BCRP (Honjo et al., 2001). Login to comment 194 ABCG2 p.Arg482Met Our preliminary analysis for the full-length BCRP cDNA identified the R482M mutation in MT-4/DOX500 cells (data not shown). Login to comment 205 ABCG2 p.Arg482Thr ABCG2 p.Arg482Gly Although this mutation differed from those observed previously in doxorubicin-resistant human cell lines (R482T or R482G), it could not be excluded that the NRTI resistance of MT-4/ DOX500 cells was caused by the mutation but not by the increased expression of BCRP. Login to comment