PMID: 26327810

Zhang W, Meng Y, Liu N, Wen XF, Yang T
Insights into Chemoresistance of Prostate Cancer.
Int J Biol Sci. 2015 Aug 1;11(10):1160-70. doi: 10.7150/ijbs.11439. eCollection 2015., [PubMed]
Sentences
No. Mutations Sentence Comment
80 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 26327810:80:110
status: NEW
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ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 26327810:80:120
status: NEW
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 MCF7/AdVp3000 cells, highly resistant to both mitoxantrone and doxorubicin, have been demonstrated to express R482T and R482G variants respectively. Login to comment 108 ABCG2 p.Thr362Ala
X
ABCG2 p.Thr362Ala 26327810:108:100
status: NEW
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 Moreover, the plasma membrane localization and drug-resistant activity of ABCG2 were compromised by T362A mutation, suggesting ABCG2 phosphorylation induced by Pim-1L is essential for ABCG2 functionality (78). Login to comment