PMID: 14633964

Dietrich CG, Geier A, Oude Elferink RP
ABC of oral bioavailability: transporters as gatekeepers in the gut.
Gut. 2003 Dec;52(12):1788-95., [PubMed]
Sentences
No. Mutations Sentence Comment
108 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 14633964:108:202
status: VERIFIED
view ABCG2 p.Arg482Thr details
ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 14633964:108:211
status: VERIFIED
view ABCG2 p.Arg482Gly details
 substrate specificity, can be the result of single amino acid mutations in the protein.88 While the wild-type protein with an arginine on position 482 confers resistance to mitoxantrone and irinotecan, R482T or R482G mutations (arginine replaced by threonine or glycine, respectively) result in additional outward transport of rhodamine and doxorubicin by BCRP. Login to comment