ABCMdb

PMID: 15716365

Xia CQ, Liu N, Yang D, Miwa G, Gan LS
Expression, localization, and functional characteristics of breast cancer resistance protein in Caco-2 cells.
Drug Metab Dispos. 2005 May;33(5):637-43. Epub 2005 Feb 16., [PubMed]

Sentences

No. Mutations Sentence Comment

135 ABCG2 p.Leu554Pro The same group also demonstrates the necessity of homodimerization for the BCRP function when using a dominant-negative mutation of BCRP with a L554P alteration in the fifth transmembrane domain (Kage et al., 2002). Login to comment 192 ABCG2 p.Arg482Thr ABCG2 p.Arg482Gly The BCRP-mediated efflux of MTX in our Caco-2 cells indicated that the BCRP expressed on Caco-2 cells might be the wild type because R482T and R482G mutation were unable to transport MTX to any extent (Chen et al., 2003). Login to comment 193 ABCG2 p.Arg482Thr ABCG2 p.Arg482Gly The conclusion is further demonstrated by the efflux of rhodamine 123, to which BCRP-conferred resistance is observed in the R482T or R482G mutation but not the wild-type expressed cell lines (Allen et al., 2002a). Login to comment