ABCMdb

PMID: 19251825

Bram EE, Adar Y, Mesika N, Sabisz M, Skladanowski A, Assaraf YG
Structural determinants of imidazoacridinones facilitating antitumor activity are crucial for substrate recognition by ABCG2.
Mol Pharmacol. 2009 May;75(5):1149-59. Epub 2009 Feb 27., [PubMed]

Sentences

No. Mutations Sentence Comment

175 ABCG2 p.Arg482Thr ABCG2 p.Arg482Gly Mutant Arg482Gly and Arg482Thr ABCG2 Do Not Alter IA Substrate Recognition. Login to comment 176 ABCG2 p.Arg482Thr ABCG2 p.Arg482Gly Previous reports have established that the Arg482Gly and Arg482Thr ABCG2 mutations resulted in altered substrate specificity and augmented cellular drug resistance (Robey et al., 2003; Shafran et al., 2005; Bram et al., 2006). Login to comment 232 ABCG2 p.Arg482Gly IA accumulation in HEK293 transfectant cells stably overexpressing wild-type Arg482 ABCG2 or mutant R482G/T ABCG2 in the presence or absence of fumitremorgin C. Login to comment