PMID: 19251825

Bram EE, Adar Y, Mesika N, Sabisz M, Skladanowski A, Assaraf YG
Structural determinants of imidazoacridinones facilitating antitumor activity are crucial for substrate recognition by ABCG2.
Mol Pharmacol. 2009 May;75(5):1149-59. Epub 2009 Feb 27., [PubMed]
Sentences
No. Mutations Sentence Comment
175 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 19251825:175:21
status: VERIFIED
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ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 19251825:175:7
status: VERIFIED
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Mutant Arg482Gly and Arg482Thr ABCG2 Do Not Alter IA Substrate Recognition. Login to comment
176 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 19251825:176:57
status: VERIFIED
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ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 19251825:176:43
status: VERIFIED
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Previous reports have established that the Arg482Gly and Arg482Thr ABCG2 mutations resulted in altered substrate specificity and augmented cellular drug resistance (Robey et al., 2003; Shafran et al., 2005; Bram et al., 2006). Login to comment
232 ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 19251825:232:100
status: VERIFIED
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IA accumulation in HEK293 transfectant cells stably overexpressing wild-type Arg482 ABCG2 or mutant R482G/T ABCG2 in the presence or absence of fumitremorgin C. Login to comment