ABCMdb

PMID: 15588721

Rhee MS, Schneider E
Lack of an effect of breast cancer resistance protein (BCRP/ABCG2) overexpression on methotrexate polyglutamate export and folate accumulation in a human breast cancer cell line.
Biochem Pharmacol. 2005 Jan 1;69(1):123-32., 2005-01-01 [PubMed]

Sentences

No. Mutations Sentence Comment

46 ABCG2 p.Arg482Gly MCF7/MX cells express the wild-type form of BCRP with an arginine at amino acid position 482 (482R), whereas the M1-80 cells have acquired a mutation at this position from arginine to glycine (R482G) [30]. Login to comment 79 ABCG2 p.Arg482Gly However, in contrast to the MCF7/MX cells, M1-80 cells are not cross-resistant to MTX [24], because their BCRP contains the R482G mutation [30] that has been shown to abolish the transport of MTX [6,22,23]. Login to comment