PMID: 15486199

Loganzo F, Hari M, Annable T, Tan X, Morilla DB, Musto S, Zask A, Kaplan J, Minnick AA Jr, May MK, Ayral-Kaloustian S, Poruchynsky MS, Fojo T, Greenberger LM
Cells resistant to HTI-286 do not overexpress P-glycoprotein but have reduced drug accumulation and a point mutation in alpha-tubulin.
Mol Cancer Ther. 2004 Oct;3(10):1319-27., [PubMed]
Sentences
No. Mutations Sentence Comment
75 ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 15486199:75:45
status: VERIFIED
view ABCG2 p.Arg482Gly details
 S1-M1-3.2, which overexpress a mutant ABCG2 (Arg482 Gly),5 and parental S1, which express low levels of wild-type ABCG2, were used as positive and negative control cell lines for ABCG2 (18). Login to comment