PMID: 15251980

Burger H, van Tol H, Boersma AW, Brok M, Wiemer EA, Stoter G, Nooter K
Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump.
Blood. 2004 Nov 1;104(9):2940-2. Epub 2004 Jul 13., 2004-11-01 [PubMed]
Sentences
No. Mutations Sentence Comment
13 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 15251980:13:121
status: VERIFIED
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ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 15251980:13:276
status: VERIFIED
view ABCG2 p.Arg482Thr details
ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 15251980:13:243
status: VERIFIED
view ABCG2 p.Arg482Gly details
 MCF7 (ATCC, HTB-22); MCF7/MR, a mitoxantrone-resistant and BCRP-overexpressing subline; MCF7/AdVp3000 overexpressing the R482T BCRP variant; HEK293 cells transfected with pcDNA3 (HEK293/Neo); wild-type BCRP/ABCG2-R482R (HEK293/R); BCRP/ ABCG2-R482G (HEK293/G); and BCRP/ABCG2-R482T (HEK293/T) were used. Login to comment