PMID: 19949921

Calcagno AM, Ambudkar SV
Molecular mechanisms of drug resistance in single-step and multi-step drug-selected cancer cells.
Methods Mol Biol. 2010;596:77-93., [PubMed]
Sentences
No. Mutations Sentence Comment
77 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 19949921:77:74
status: VERIFIED
view ABCG2 p.Arg482Thr details
 Unlike the MCF-7/FLV1000, the MCF-7 AdVp3000 expressed the mutant ABCG2 R482T. Login to comment 81 ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 19949921:81:42
status: VERIFIED
view ABCG2 p.Arg482Gly details
 These S1 sublines also expressed a mutant R482G ABCG2 protein. Login to comment 85 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 19949921:85:110
status: VERIFIED
view ABCG2 p.Arg482Thr details
ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 19949921:85:120
status: VERIFIED
view ABCG2 p.Arg482Gly details
 In the case of ABCG2-overexpressing cell lines in vitro, two gain of function mutations have been identified (R482T and R482G). Login to comment