ABCMdb

PMID: 21821808

Real R, Gonzalez-Lobato L, Baro MF, Valbuena S, de la Fuente A, Prieto JG, Alvarez AI, Marques MM, Merino G
Analysis of the effect of the bovine adenosine triphosphate-binding cassette transporter G2 single nucleotide polymorphism Y581S on transcellular transport of veterinary drugs using new cell culture models.
J Anim Sci. 2011 Dec;89(12):4325-38. doi: 10.2527/jas.2011-3841. Epub 2011 Aug 5., [PubMed]

Sentences

No. Mutations Sentence Comment

217 ABCG2 p.Gln141Lys As an example, the Q141K variant in humans has been related to altered pharmacokinetics of several substrates (Cusatis and Sparreboom, 2008; Keskitalo et al., 2009), and more recently, it has been reported as a loss-of-function mutation that causes hyperuricemia and gout in humans (Woodward et al., 2009). Login to comment 255 ABCG2 p.Arg482Thr ABCG2 p.Arg482Gly In this way, the R482G and R482T variants show increased transport and ATP hydrolytic-activity for various compounds (Ozvegy et al., 2002). Login to comment 256 ABCG2 p.Ile206Leu Another ABCG2 variant, I206L [so far, only identified in Hispanic livers (Zamber et al., 2003)], also exhibits 2 to 3 times greater drug resistance capacity than that of wild-type protein (Vethanayagam et al., 2005). Login to comment 257 ABCG2 p.Ile206Leu These authors suggest that the increased transport activity of I206L could be the result of greater affinity of substrates or augmented transport efficiency for this protein variant. Login to comment 480 ABCG2 p.Ile206Leu ABCG2 p.Asn590Tyr ABCG2 p.Asp620Asn Functional analysis of the human variants of breast cancer resistance protein: I206L, N590Y, and D620N. Login to comment