ABCMdb

PMID: 18824523

Merino G, Real R, Baro MF, Gonzalez-Lobato L, Prieto JG, Alvarez AI, Marques MM
Natural allelic variants of bovine ATP-binding cassette transporter ABCG2: increased activity of the Ser581 variant and development of tools for the discovery of new ABCG2 inhibitors.
Drug Metab Dispos. 2009 Jan;37(1):5-9. Epub 2008 Sep 29., [PubMed]

Sentences

No. Mutations Sentence Comment

18 ABCG2 p.Gln141Lys For instance, the significance of the Q141K SNP has been shown in vitro (Mizuarai et al., 2004) and in clinical studies (Sparreboom et al., 2004; Yamasaki et al., 2008). Login to comment 121 ABCG2 p.Ile206Leu For example, the I206L variant exhibits 2 to 3 times higher efflux activities and drug resistance capabilities than that of wild-type protein (Vethanayagam et al., 2005). Login to comment 180 ABCG2 p.Arg482Gly Clark R, Kerr ID, and Callaghan R (2006) Multiple drug binding sites on the R482G isoform of the ABCG2 transporter. Login to comment 218 ABCG2 p.Ile206Leu ABCG2 p.Asn590Tyr ABCG2 p.Asp620Asn Vethanayagam RR, Wang H, Gupta A, Zhang Y, Lewis F, Unadkat JD, and Mao Q (2005) Functional analysis of the human variants of breast cancer resistance protein: I206L, N590Y, and D620N. Login to comment