ABCMdb

PMID: 15165903

Sarkadi B, Ozvegy-Laczka C, Nemet K, Varadi A
ABCG2 -- a transporter for all seasons.
FEBS Lett. 2004 Jun 1;567(1):116-20., 2004-06-01 [PubMed]

Sentences

No. Mutations Sentence Comment

109 ABCG2 p.Arg482Gly Transported substrates of the wild-type and R482G ABCG2 protein. Login to comment 119 ABCG2 p.Arg482Thr ABCG2 p.Arg482Gly ABCG2 p.Arg482Ser ABCG2 p.Arg482Met The mutants having R482G or R482T (R482M or R482S in the mouse abcg2) showed altered substrate specificity as compared to the wild-type protein, i.e., they conferred increased mitoxantrone or doxorubicin (DOX) resistance and rhodamine 123 transport capacity (see Fig. 2, [42,43]). Login to comment 121 ABCG2 p.Arg482Thr ABCG2 p.Arg482Gly However, the R482G and R482T mutants were not able to transport methotrexate, which is a transported substrate of the wild-type ABCG2 [15,44]. Login to comment 127 ABCG2 p.Gln141Lys ABCG2 p.Val12Met These SNPs yield ABCG2 variants containing V12M and Q141K. Login to comment 135 ABCG2 p.Arg482Gly Since the R482G variant of ABCG2 has different substrate specificity than the wild-type protein (Fig. 2), this mutant has a special advantage in gene therapy applications. Login to comment