PMID: 18523872

Muenster U, Grieshop B, Ickenroth K, Gnoth MJ
Characterization of substrates and inhibitors for the in vitro assessment of Bcrp mediated drug-drug interactions.
Pharm Res. 2008 Oct;25(10):2320-6. Epub 2008 Jun 4., [PubMed]
Sentences
No. Mutations Sentence Comment
129 ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 18523872:129:89
status: VERIFIED
view ABCG2 p.Arg482Gly details
 Recently strong evidence for the existence of at least two separate binding sites in the R482G BCRP mutant has been presented (31). Login to comment 142 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 18523872:142:113
status: VERIFIED
view ABCG2 p.Arg482Thr details
 Also Nakanishi et al. speculated a complex interaction of substrate with the BCRP transport protein (WT-BCRP and R482T variant), since in their substrate interaction studies using Rhodamin 123, topotecan, mitoxantrone, and flavopiridol, no two substrates reciprocally inhibited the efflux of the other (32). Login to comment