PMID: 17904109

Korynevska A, Heffeter P, Matselyukh B, Elbling L, Micksche M, Stoika R, Berger W
Mechanisms underlying the anticancer activities of the angucycline landomycin E.
Biochem Pharmacol. 2007 Dec 15;74(12):1713-26. Epub 2007 Aug 25., 2007-12-15 [PubMed]
Sentences
No. Mutations Sentence Comment
284 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 17904109:284:129
status: NEW
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ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 17904109:284:119
status: NEW
view ABCG2 p.Arg482Gly details
 Interestingly, anthracyclines are not transported by wild-type BCRP but are substrates of the polymorphic BCRP mutants R482G and R482T only [4,40]. Login to comment 285 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 17904109:285:87
status: NEW
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 The cell line we used in this study was transfected with a BCRP plasmid, which has the R482T mutation [4,41] and has been shown to confer resistance against ADR and DNR [4]. Login to comment 387 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 17904109:387:35
status: NEW
view ABCG2 p.Arg482Thr details
 [41] Alqawi O, Bates S, Georges E. Arginine482 to threonine mutation in the breast cancer resistance protein ABCG2 inhibits rhodamine 123 transport while increasing binding. Login to comment