ABCMdb

PMID: 14754410

Han B, Zhang JT
Multidrug resistance in cancer chemotherapy and xenobiotic protection mediated by the half ATP-binding cassette transporter ABCG2.
Curr Med Chem Anticancer Agents. 2004 Jan;4(1):31-42., [PubMed]

Sentences

No. Mutations Sentence Comment

106 ABCG2 p.Arg482Thr ABCG2 p.Arg482Gly ABCG2 p.Arg482Met However, no polymorphism at amino acid 482 was identified to correspond to the Arg482 Gly, Arg482 Met, or Arg482 Thr mutation that has been identified in drug selected cell lines. Login to comment 108 ABCG2 p.Gln141Lys ABCG2 p.Val12Met ABCG2 p.Asp620Asn Nonsynonymous SNPs at nucleotide 238 (Val12 Met; exon 2) and nucleotide 625 (Gln141 Lys; exon 5) showed a greater frequency of heterozygosity (22.2% and 10%, respectively) than the SNP at 2062 (Asp620 Asn; exon 16). Login to comment 113 ABCG2 p.Gln141Lys ABCG2 p.Val12Met Two non-synonymous SNPs, Val12 Met and Gln141 Lys, were also identified, which are consistent with the study by Honjo et al. [25]. Login to comment 115 ABCG2 p.Gln141Lys Genotyping of these sequence variations revealed linkage between the CTCA deletion and the SNP of Gln141 Lys. Login to comment