ABCMdb

PMID: 19232821

Dai CL, Liang YJ, Wang YS, Tiwari AK, Yan YY, Wang F, Chen ZS, Tong XZ, Fu LW
Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2.
Cancer Lett. 2009 Jun 28;279(1):74-83. Epub 2009 Feb 18., 2009-06-28 [PubMed]

Sentences

No. Mutations Sentence Comment

26 ABCG2 p.Arg482Thr ABCG2 p.Arg482Gly In contrast, cells carrying a glycine (R482G) or a threonine (R482T) at position 482 were able to transport rhodamine 123 and doxorubicin, while also maintained their ability to transport mitoxantrone. Login to comment 27 ABCG2 p.Arg482Thr ABCG2 p.Arg482Gly The ABCG2 variants were found in drug-resistant S1-M1-80 (R482G) and MCF-7 AdVp3000 (R482T) but not in the parental S1 and MCF-7 cell lines, suggesting that these were acquired mutations resulting from drug selection. Login to comment