PMID: 21402712

Shi Z, Tiwari AK, Shukla S, Robey RW, Singh S, Kim IW, Bates SE, Peng X, Abraham I, Ambudkar SV, Talele TT, Fu LW, Chen ZS
Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance.
Cancer Res. 2011 Apr 15;71(8):3029-41. Epub 2011 Mar 14., 2011-04-15 [PubMed]
Sentences
No. Mutations Sentence Comment
110 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 21402712:110:234
status: VERIFIED
view ABCG2 p.Arg482Thr details
ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 21402712:110:224
status: VERIFIED
view ABCG2 p.Arg482Gly details
 It has been reported that mutations at amino acid 482 in ABCG2 alter the substrate and antagonist specificity of ABCG2 (16, 25); therefore, we examined the reversing effect of sildenafil on both wild-type (R482) and mutant (R482G and R482T) ABCG2-overexpressing cells. Login to comment 111 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 21402712:111:234
status: NEW
view ABCG2 p.Arg482Thr details
ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 21402712:111:224
status: NEW
view ABCG2 p.Arg482Gly details
 It has been reported that mutations at amino acid 482 in ABCG2 alter the substrate and antagonist specificity of ABCG2 (16, 25); therefore, we examined the reversing effect of sildenafil on both wild-type (R482) and mutant (R482G and R482T) ABCG2-overexpressing cells. Login to comment