PMID: 17616561

Matsson P, Englund G, Ahlin G, Bergstrom CA, Norinder U, Artursson P
A global drug inhibition pattern for the human ATP-binding cassette transporter breast cancer resistance protein (ABCG2).
J Pharmacol Exp Ther. 2007 Oct;323(1):19-30. Epub 2007 Jul 6., [PubMed]
Sentences
No. Mutations Sentence Comment
279 ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 17616561:279:273
status: VERIFIED
view ABCG2 p.Arg482Gly details
 Biochemical data suggests as many as four distinct drug binding sites for P-gp (Shapiro and Ling, 1997; Ambudkar et al., 2006); likewise, the existence of two or three distinct but symmetrical binding sites has recently been suggested for the wild-type Arg482 BCRP and the R482G mutant isoform, respectively (Ejendal and Hrycyna, 2005; Clark et al., 2006). Login to comment