PMID: 16169662

Huang Y, Sadee W
Membrane transporters and channels in chemoresistance and -sensitivity of tumor cells.
Cancer Lett. 2006 Aug 8;239(2):168-82. Epub 2005 Oct 5., 2006-08-08 [PubMed]
Sentences
No. Mutations Sentence Comment
76 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 16169662:76:101
status: VERIFIED
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ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 16169662:76:92
status: VERIFIED
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 A mutational hot spot is located in position 482 of ABCG2 where a single amino acid change (R482G or R482T) occurs [25]. Login to comment 79 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 16169662:79:35
status: VERIFIED
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ABCG2 p.Val12Met
X
ABCG2 p.Val12Met 16169662:79:26
status: VERIFIED
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 Two additional SNPs, i.e. V12M and Q141K, also affect substrate specificity and transport capacity of ABCG2 [26]. Login to comment