PMID: 23084250

Zhang Y, Pullambhatla M, Laterra J, Pomper MG
Influence of bioluminescence imaging dynamics by D-luciferin uptake and efflux mechanisms.
Mol Imaging. 2012 Nov-Dec;11(6):499-506., [PubMed]
Sentences
No. Mutations Sentence Comment
48 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 23084250:48:72
status: NEW
view ABCG2 p.Arg482Thr details
ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 23084250:48:87
status: NEW
view ABCG2 p.Arg482Gly details
 On the other hand, expressing either of two mutant forms of ABCG2, T10 (R482T) and G2 (R482G), each of which has altered substrate specificity and does not transport D-luciferin as effectively as wt ABCG2,5,13 failed to restore the signal enhancement by HhAntag-691 (Figure 2, C and D). Login to comment