PMID: 23467750

Zoernig I, Ziegelmeier C, Lahrmann B, Grabe N, Jager D, Halama N
Sequence mutations of the substrate binding pocket of stem cell factor and multidrug resistance protein ABCG2 in renal cell cancer: a possible link to treatment resistance.
Oncol Rep. 2013 May;29(5):1697-700. doi: 10.3892/or.2013.2324. Epub 2013 Mar 5., [PubMed]
Sentences
No. Mutations Sentence Comment
88 ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 23467750:88:140
status: NEW
view ABCG2 p.Arg482Gly details
 It has been hypothesized that residue R482 in the transmembrane domain 3 (TM3) is likely to interact with substrates based on the effect of R482G/T mutations (29). Login to comment 92 ABCG2 p.Tyr459Cys
X
ABCG2 p.Tyr459Cys 23467750:92:39
status: NEW
view ABCG2 p.Tyr459Cys details
 Our data shows a mutation resulting in Y459C in the intracellular domain 1a (ICD1a). Login to comment