ABCMdb

PMID: 12960118

Nakanishi T, Karp JE, Tan M, Doyle LA, Peters T, Yang W, Wei D, Ross DD
Quantitative analysis of breast cancer resistance protein and cellular resistance to flavopiridol in acute leukemia patients.
Clin Cancer Res. 2003 Aug 15;9(9):3320-8., 2003-08-15 [PubMed]

Sentences

No. Mutations Sentence Comment

50 ABCG2 p.Arg482Thr ABCG2 p.Arg482Gly The codon 482 mutations observed have substitutions of threonine (R482T) or glycine (R482G), which results in the ability of the mutant protein to transport anthracyclines and rhodamine 123 but loss of ability to transport methotrexate (29-31). Login to comment 91 ABCG2 p.Arg482Thr For authentic BCRP in vitro-transcribed RNA (cRNA) R482 and R482T standards, the Tms of the hybridization probes are 62°C and 57.2°C, respectively. Login to comment 218 ABCG2 p.Arg482Thr ABCG2 p.Arg482Gly Recently, the R482T and R482G mutations of BCRP have been described. Login to comment 220 ABCG2 p.Arg482Thr ABCG2 p.Arg482Gly Additionally, a recent study (31) indicates that the R482T and R482G mutations result in loss of the ability to transport methotrexate. Login to comment