PMID: 17347325

Pal A, Mehn D, Molnar E, Gedey S, Meszaros P, Nagy T, Glavinas H, Janaky T, von Richter O, Bathori G, Szente L, Krajcsi P
Cholesterol potentiates ABCG2 activity in a heterologous expression system: improved in vitro model to study function of human ABCG2.
J Pharmacol Exp Ther. 2007 Jun;321(3):1085-94. Epub 2007 Mar 8., [PubMed]
Sentences
No. Mutations Sentence Comment
30 ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 17347325:30:4
status: VERIFIED
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 The R482G/T mutants display a substrate specificity different from the wild-type (WT) protein (Honjo et al., 2001; Ozvegy et al., 2002). Login to comment 31 ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 17347325:31:51
status: VERIFIED
view ABCG2 p.Arg482Gly details
 More strikingly, unlike the ATPase function of the R482G/T mutants, the ATPase activity of the WT protein could not be stimulated by prazosin, a known ABCG2 substrate (Xiao et al., 2006), when expressed in insect cell membranes (Ozvegy et al., 2001; Ishikawa et al., 2003). Login to comment