PMID: 16489126

Saito H, Hirano H, Nakagawa H, Fukami T, Oosumi K, Murakami K, Kimura H, Kouchi T, Konomi M, Tao E, Tsujikawa N, Tarui S, Nagakura M, Osumi M, Ishikawa T
A new strategy of high-speed screening and quantitative structure-activity relationship analysis to evaluate human ATP-binding cassette transporter ABCG2-drug interactions.
J Pharmacol Exp Ther. 2006 Jun;317(3):1114-24. Epub 2006 Feb 17., [PubMed]
Sentences
No. Mutations Sentence Comment
202 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 16489126:202:81
status: VERIFIED
view ABCG2 p.Arg482Thr details
ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 16489126:202:71
status: VERIFIED
view ABCG2 p.Arg482Gly details
 The wild type of ABCG2 transports MTX, whereas acquired mutants, i.e., R482G and R482T, do not (Mitomo et al., 2003). Login to comment