ABCMdb

PMID: 18089722

Wu CP, Shukla S, Calcagno AM, Hall MD, Gottesman MM, Ambudkar SV
Evidence for dual mode of action of a thiosemicarbazone, NSC73306: a potent substrate of the multidrug resistance linked ABCG2 transporter.
Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3287-96., [PubMed]

Sentences

No. Mutations Sentence Comment

112 ABCG2 p.Arg482Thr Using flow cytometry with wild type R482-HEK293 cells (Fig. 1, top panel), ABCG2-expressing MCF-7 FLV1000 cells and ABCG2 mutant R482T MCF-7 AdVp3000 cells (Fig. 1, bottom panel), the intensities of the accumulated fluorescent substrates were then analyzed as described in Materials and Methods. Login to comment 132 ABCG2 p.Arg482Thr December 2007 American Association for Cancer ResearchCopyright (c) 2007 on May 3, (Fig. 1, top), ABCG-expressing MCF-7 FLV1000 cells, and ABCG2 mutant R482T MCF-7 AdVp3000 cells (Fig. 1, bottom), the intensities of the accumulated fluorescent substrates were then analyzed as described in Materials and Methods. Login to comment 200 ABCG2 p.Lys86Met Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2. Login to comment 341 ABCG2 p.Arg482Gly Multiple drugbinding sites on the R482G isoform of the ABCG2 transporter. Login to comment