PMID: 19059384

Shi Z, Tiwari AK, Shukla S, Robey RW, Kim IW, Parmar S, Bates SE, Si QS, Goldblatt CS, Abraham I, Fu LW, Ambudkar SV, Chen ZS
Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478.
Biochem Pharmacol. 2009 Mar 1;77(5):781-93. Epub 2008 Nov 18., 2009-03-01 [PubMed]
Sentences
No. Mutations Sentence Comment
138 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 19059384:138:228
status: NEW
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ABCG2 p.Arg482Gly
X
ABCG2 p.Arg482Gly 19059384:138:218
status: NEW
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 It has been reported that mutations at amino-acid 482 in ABCG2 alter the substrate and antagonist specificity of ABCG2 [16,25], therefore we examined the reversing effect of AG1478 on both wild-type (R482) and mutant (R482G and R482T) ABCG2. Login to comment 261 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 19059384:261:72
status: NEW
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 Recently, one common functional single-nucleotide polymorphism of ABCG2 Q141K (421C ! Login to comment